| Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal. | Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal.
Zhang N, Yang A, Zhang W, Li H, Xu A, Yan X, Han Q, Wang B, You H, Chen W., Free PMC Article | 03/14/2024 |
| Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/beta-catenin via HIF-1a repression in 3T3-L1 cells. | Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells.
Zhang J, Ye F, Ye A, He B., Free PMC Article | 12/6/2023 |
| MiR-590-3p Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells by Targeting Lysyl Oxidase. | MiR-590-3p Promotes the Phenotypic Switching of Vascular Smooth Muscle Cells by Targeting Lysyl Oxidase.
Wang L, Zhang L, Cui LK, Yue X, Huang L, Liu N, Zhu MD, Wang ZB. | 11/13/2023 |
| Sox6 impairs the adipogenic commitment of mesenchymal stem cells by targeting lysyl oxidase and preadipocyte factor 1. | Sox6 impairs the adipogenic commitment of mesenchymal stem cells by targeting lysyl oxidase and preadipocyte factor 1.
Du SY, Hu L, Zhou BH, Zhang Z, Li MC, Chang D, Xu CJ, Dou X. | 11/2/2023 |
| CD11b Deficiency Favors Cartilage Calcification via Increased Matrix Vesicles, Apoptosis, and Lysyl Oxidase Activity. | CD11b Deficiency Favors Cartilage Calcification via Increased Matrix Vesicles, Apoptosis, and Lysyl Oxidase Activity.
Bernabei I, Hansen U, Ehirchiou D, Brinckmann J, Chobaz V, Busso N, Nasi S., Free PMC Article | 06/15/2023 |
| The Lysyl Oxidase G473A Polymorphism Exacerbates Oral Cancer Development in Humans and Mice. | The Lysyl Oxidase G473A Polymorphism Exacerbates Oral Cancer Development in Humans and Mice.
Peymanfar Y, Mahjour F, Shrestha N, de la Cueva A, Chen Y, Huang S, Kirsch KH, Han X, Trackman PC., Free PMC Article | 06/13/2023 |
| Estrogen-related receptor gamma (ERRgamma) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes. | Estrogen-related receptor γ (ERRγ) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
Fan Y, Na SY, Jung YS, Radhakrishnan K, Choi HS. | 04/19/2023 |
| Lysyl oxidase regulation and protein aldehydes in the injured newborn lung. | Lysyl oxidase regulation and protein aldehydes in the injured newborn lung.
Zhong Y, Mahoney RC, Khatun Z, Chen HH, Nguyen CT, Caravan P, Roberts JD Jr., Free PMC Article | 02/19/2022 |
| Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity. | Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity.
Huang A, Lin YS, Kao LZ, Chiou YW, Lee GH, Lin HH, Wu CH, Chang CS, Lee KT, Hsueh YY, Tsai PJ, Tang MJ, Tsai YS., Free PMC Article | 02/12/2022 |
| Progression and Regression of Abdominal Aortic Aneurysms in Mice. | Progression and Regression of Abdominal Aortic Aneurysms in Mice.
Ding YC, Zhang XJ, Zhang JX, Zhai ZY, Zhang MX, Jiang BH. | 02/5/2022 |
| LOXG473A induces the formation of osteoclasts in RAW264.7 cells via IL-6/JAK2/STAT3 signaling. | LOX(G473A) induces the formation of osteoclasts in RAW264.7 cells via IL-6/JAK2/STAT3 signaling.
Xiao W, Shen Y, Xu Y. | 12/11/2021 |
| Lysyl Oxidase Inhibition Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice. | Lysyl Oxidase Inhibition Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice.
Okuyama M, Jiang W, Javidan A, Chen JZ, Howatt DA, Yang L, Hamaguchi M, Yasugi T, Aono J, Vazquez-Padron RI, Subramanian V., Free PMC Article | 10/2/2021 |
| Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress. | Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.
Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP., Free PMC Article | 10/24/2020 |
| TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro. | TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
Shearer D, Mervis MO, Manley E Jr, Reddy AB, Alford AI. | 08/22/2020 |
| Findings highlight that LOX correlates with TSP2 levels in actively producing extracellular matrix conditions, both in vitro and in vivo. | Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.
Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR., Free PMC Article | 05/9/2020 |
| Hypoxia-inducible factor (HIF) 2alpha (HIF2A) accelerates extracellular matrix deposition by inducing a collagen-cross-linking enzyme, lysyl oxidase (LOX). | HIF2A-LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy.
Hikage F, Atkins S, Kahana A, Smith TJ, Chun TH., Free PMC Article | 02/1/2020 |
| we demonstrate that Lox/CHOP-10 crosstalk regulates BMP4-induced osteogenic and adipogenic fate determination of MSCs, presenting a promising therapeutic target for osteoporosis and other bone diseases. | A Lox/CHOP-10 crosstalk governs osteogenic and adipogenic cell fate by MSCs.
Jiang WY, Xing C, Wang HW, Wang W, Chen SZ, Ning LF, Xu X, Tang QQ, Huang HY., Free PMC Article | 11/23/2019 |
| the copper transporter ATP7A is necessary for the activity of LOX and LOXL enzymes. Silencing of ATP7A inhibited LOX activity in the 4T1 mammary carcinoma cell line. | ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis.
Shanbhag V, Jasmer-McDonald K, Zhu S, Martin AL, Gudekar N, Khan A, Ladomersky E, Singh K, Weisman GA, Petris MJ., Free PMC Article | 05/25/2019 |
| Mice expressing Arg152Gln mutation in in propeptide domain of LOX exhibit accelerated tumor development and higher tumor weight | A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer.
de la Cueva A, Emmerling M, Lim SL, Yang S, Trackman PC, Sonenshein GE, Kirsch KH., Free PMC Article | 03/9/2019 |
| High HIC5 expression is associated with tumorigenesis of colorectal cancer. | The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A. | 03/9/2019 |
| LOX over-expression in vascular smooth muscle cells was associated with a change in the structure of collagen and elastin fibres; LOX could constitute a novel source of oxidative stress that might participate in elastin changes and contribute to vascular remodelling | Vascular lysyl oxidase over-expression alters extracellular matrix structure and induces oxidative stress.
Varona S, García-Redondo AB, Martínez-González J, Salaices M, Briones AM, Rodríguez C. | 09/8/2018 |
| LOX up-regulation is associated with enhanced oxidative stress that promotes p38MAPK activation, elastin structural alterations, and vascular stiffness. | Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK.
Martínez-Revelles S, García-Redondo AB, Avendaño MS, Varona S, Palao T, Orriols M, Roque FR, Fortuño A, Touyz RM, Martínez-González J, Salaices M, Rodríguez C, Briones AM., Free PMC Article | 03/17/2018 |
| These results suggest that LOX has the ability to induce RANKL expression on stromal cells; however, it fails to substitute for RANKL in osteoclastogenesis. | LOX Fails to Substitute for RANKL in Osteoclastogenesis.
Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win SJ, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H. | 01/13/2018 |
| UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. | UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.
Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. | 12/30/2017 |
| Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 receptor signaling. | Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling.
Griner JD, Rogers CJ, Zhu MJ, Du M., Free PMC Article | 12/2/2017 |