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    Lpl lipoprotein lipase [ Mus musculus (house mouse) ]

    Gene ID: 16956, updated on 26-Jul-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells.

    GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells.
    Meng X, Zeng W, Young SG, Fong LG., Free PMC Article

    07/24/2021
    beta-Estradiol Enhanced Secretion of Lipoprotein Lipase from Mouse Mammary Tumor FM3A Cells.

    β-Estradiol Enhanced Secretion of Lipoprotein Lipase from Mouse Mammary Tumor FM3A Cells.
    Fujii T, Ogasawara M, Kamishikiryo J, Morita T.

    06/19/2021
    Lpl-C310R mutation is associated with impaired glucose tolerance and endoplasmic reticulum stress in skeletal muscle.

    Lpl-C310R mutation is associated with impaired glucose tolerance and endoplasmic reticulum stress in skeletal muscle.
    Yue XY, Sun XF, Che K, Hu JX, Lv WS, Sun XL, Geng Z, Chi JW, Wang YG.

    02/13/2021
    Kruppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.

    Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.
    Xie W, Li L, Gong D, Zhang M, Lv YC, Guo DM, Zhao ZW, Zheng XL, Zhang DW, Dai XY, Yin WD, Tang CK.

    08/15/2020
    data indicate that apoE determines the metabolic impact of apoC-III as we establish that apoE is essential to mediate inhibition of TRL clearance by apoC-III and that, in the absence of functional apoE, apoC-III inhibits tissue LPL activity.

    ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance.
    Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM., Free PMC Article

    07/18/2020
    The study suggests a VDR-mediated metabolic cross-talk between gut and adipose tissue, and identifies the potent LPL inhibitor Angptl4 as a novel transcriptional target of VDR.

    Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice.
    Jahn D, Dorbath D, Schilling AK, Gildein L, Meier C, Vuille-Dit-Bille RN, Schmitt J, Kraus D, Fleet JC, Hermanns HM, Geier A.

    02/8/2020
    Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulin resistance

    Epigenetic regulation of lipoprotein lipase gene via BRD4, which is potentially associated with adipocyte differentiation and insulin resistance.
    Inoue T, Hariya N, Imamochi Y, Dey A, Ozato K, Goda T, Kubota T, Mochizuki K.

    01/25/2020
    miR-182 upregulates LPL expression, promotes lipid accumulation in atherosclerotic lesions, and increases proinflammatory cytokine secretion, likely through targetingHDAC9, leading to an acceleration of atherogenesis in ApoE-KO mice.

    MicroRNA-182 Promotes Lipoprotein Lipase Expression and Atherogenesisby Targeting Histone Deacetylase 9 in Apolipoprotein E-Knockout Mice.
    Cheng HP, Gong D, Zhao ZW, He PP, Yu XH, Ye Q, Huang C, Zhang X, Chen LY, Xie W, Zhang M, Li L, Xia XD, Ouyang XP, Tan YL, Wang ZB, Tian GP, Zheng XL, Yin WD, Tang CK.

    03/9/2019
    LpL regulates peripheral leukocyte levels and affects bone marrow monocyte progenitor differentiation and aortic macrophage accumulation.

    Lipoprotein Lipase Deficiency Impairs Bone Marrow Myelopoiesis and Reduces Circulating Monocyte Levels.
    Chang CL, Garcia-Arcos I, Nyrén R, Olivecrona G, Kim JY, Hu Y, Agrawal RR, Murphy AJ, Goldberg IJ, Deckelbaum RJ., Free PMC Article

    01/12/2019
    LPL-mediated release of essential fatty acid DHA regulates hematopoietic stem progenitor cell expansion and definitive hematopoiesis

    Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.
    Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana TM, Traver D, Miller YI., Free PMC Article

    12/22/2018
    the negatively charged IDR of GPIHBP1 traverses a vast space, facilitating capture of LPL by capillary endothelial cells and simultaneously contributing to GPIHBP1's ability to preserve LPL structure and activity.

    A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase.
    Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M., Free PMC Article

    09/8/2018
    LPL in the hypothalamus is an important regulator of body weight and glucose homeostasis

    Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice.
    Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Prévot V, Tschöp MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C.

    05/12/2018
    These results identify LPL as an important regulator of fatty acid transport to skeletal compartments and demonstrate an intricate functional link between systemic and skeletal fatty acid and glucose metabolism.

    Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase.
    Bartelt A, Koehne T, Tödter K, Reimer R, Müller B, Behler-Janbeck F, Heeren J, Scheja L, Niemeier A., Free PMC Article

    03/24/2018
    mutation of a conserved cysteine in GPIHBP1 abolishes the ability of GPIHBP1 to bind LPL

    Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding.
    Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG., Free PMC Article

    03/10/2018
    The data suggests that ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.

    ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.
    Xiao HB, Wang JY, Sun ZL.

    12/9/2017
    Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b.

    Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
    Kang DY, S P N, Darvin P, Joung YH, Byun HJ, Do CH, Park KD, Park MN, Cho KH, Yang YM.

    10/14/2017
    physiological changes in adipose tissue ANGPTL4 expression during fasting and cold resulted in inverse changes in the amount of mature-glycosylated LPL in wild-type mice, but not Angptl4(-/-) mice. We conclude that ANGPTL4 promotes loss of intracellular LPL by stimulating LPL degradation after LPL processing in the endoplasmic reticulum (ER).

    Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes.
    Dijk W, Beigneux AP, Larsson M, Bensadoun A, Young SG, Kersten S., Free PMC Article

    09/2/2017
    LPL moved quickly from heparan sulfate proteoglycans (HSPGs) on adipocytes to GPIHBP1-coated beads, thereby depleting LPL stores on the surface of adipocytes. We conclude that HSPG-bound LPL in the interstitial spaces of tissues is mobile, allowing the LPL to move to GPIHBP1 on endothelial cells

    Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries.
    Allan CM, Larsson M, Jung RS, Ploug M, Bensadoun A, Beigneux AP, Fong LG, Young SG., Free PMC Article

    08/26/2017
    our study reveals that hepatic LPL is involved in the regulation of plasma LPL activity and lipid homeostasis.

    Regulation of plasma lipid homeostasis by hepatic lipoprotein lipase in adult mice.
    Liu G, Xu JN, Liu D, Ding Q, Liu MN, Chen R, Fan M, Zhang Y, Zheng C, Zou DJ, Lyu J, Zhang WJ., Free PMC Article

    08/26/2017
    The induction of LPL activity by fasting in core transgenic mice activated PPARalpha downstream target genes that are involved in fatty acid beta-oxidation.

    Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation.
    Sun HY, Lin CC, Tsai PJ, Tsai WJ, Lee JC, Tsao CW, Cheng PN, Wu IC, Chiu YC, Chang TT, Young KC.

    07/29/2017
    This study shows that TNF-alpha, by a Foxo1 dependent pathway, increases the transcription of ANGPTL4 which is secreted by the cells and causes inactivation of LPL.

    TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4.
    Makoveichuk E, Vorrsjö E, Olivecrona T, Olivecrona G.

    07/15/2017
    Our findings suggest that neuronal LPL is involved in the regulation of body weight and composition in response to either the change in quantity (HF feeding) or quality (n-3 PUFA-enriched) of dietary fat

    Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition.
    Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH.

    05/20/2017
    An LPL structural model suggests that the LPL S447X truncation exposes residues implicated in LPL binding to lipoprotein binding uptake receptors, such as GPIHBP1.

    Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPL<sup>S447X</sup>, Reveals Increased Lipoprotein Uptake.
    Hayne CK, Lafferty MJ, Eglinger BJ, Kane JP, Neher SB., Free PMC Article

    05/20/2017
    feeding induces lipasin, activating the lipasin-Angptl3 pathway, which inhibits LPL in cardiac and skeletal muscles to direct circulating TAG to WAT for storage

    A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase.
    Fu Z, Abou-Samra AB, Zhang R., Free PMC Article

    10/22/2016
    MiR-590 agomir down-regulates LPL mRNA and protein expression in a mouse model of atherosclerosis.

    MicroRNA-590 Inhibits Lipoprotein Lipase Expression and Prevents Atherosclerosis in apoE Knockout Mice.
    He PP, OuYang XP, Li Y, Lv YC, Wang ZB, Yao F, Xie W, Tan YL, Li L, Zhang M, Lan G, Gong D, Cheng HP, Zhong HJ, Liu D, Huang C, Li ZX, Zheng XL, Yin WD, Tang CK., Free PMC Article

    06/4/2016
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