| LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments. | LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments.
Tang W, Luan Y, Yuan Q, Li A, Chen S, Menacherry S, Young L, Wu D., Free PMC Article | 04/24/2024 |
| The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration. | The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration.
Turkkahraman H, Flanagan S, Zhu T, Bellido TM, Yuan X., | 07/24/2023 |
| Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets. | Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets.
Zeng Y, Zhang Z, Liang S, Chang X, Qin R, Chen H, Guo L. | 04/14/2023 |
| In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions. | In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.
Gessler L, Kurtek C, Merholz M, Jian Y, Hashemolhosseini S., Free PMC Article | 01/14/2023 |
| mTOR is involved in LRP5-induced osteogenic differentiation of normal and aged periodontal ligament stem cells in vitro. | mTOR is involved in LRP5-induced osteogenic differentiation of normal and aged periodontal ligament stem cells in vitro.
Yu K, Wang C, Li Y, Jiang Z, Yang G, Wang Y. | 09/24/2022 |
| LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway. | LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway.
Zhou H, Zhang F, Wu Y, Liu H, Duan R, Liu Y, Wang Y, He X, Zhang Y, Ma X, Guan Y, Liu Y, Liang D, Zhou L, Chen YH., Free PMC Article | 05/21/2022 |
| LRP5 Promotes Gastric Cancer via Activating Canonical Wnt/beta-Catenin and Glycolysis Pathways. | LRP5 Promotes Gastric Cancer via Activating Canonical Wnt/β-Catenin and Glycolysis Pathways.
Nie X, Wang H, Wei X, Li L, Xue T, Fan L, Ma H, Xia Y, Wang YD, Chen WD. | 05/7/2022 |
| The Effect of Overexpression of Lrp5 on the Temporomandibular Joint. | The Effect of Overexpression of Lrp5 on the Temporomandibular Joint.
Utreja A, Motevasel H, Bain C, Holland R, Robling A., Free PMC Article | 04/16/2022 |
| Aberrantly activated Wnt/beta-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2(S252W) (/+) ) mouse model. | Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2(S252W)(/+) ) mouse model.
Min Swe NM, Kobayashi Y, Kamimoto H, Moriyama K. | 01/29/2022 |
| Fork-shaped mandibular incisors as a novel phenotype of LRP5-associated disorder. | Fork-shaped mandibular incisors as a novel phenotype of LRP5-associated disorder.
Yamada M, Kubota K, Uchida A, Yagihashi T, Kawasaki M, Suzuki H, Uehara T, Takenouchi T, Kurosaka H, Kosaki K. | 08/14/2021 |
| Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes. | Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.
Leanza G, Fontana F, Lee SY, Remedi MS, Schott C, Ferron M, Hamilton-Hall M, Alippe Y, Strollo R, Napoli N, Civitelli R., Free PMC Article | 08/14/2021 |
| The effect of overexpression of Lrp5 on orthodontic tooth movement. | The effect of overexpression of Lrp5 on orthodontic tooth movement.
Holland R, Bain C, Alrasheed RS, Robling AG, Utreja A. | 07/31/2021 |
| Combination therapy in the Col1a2(G610C) mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFbeta signaling on trabecular bone but not on cortical bone. | Combination therapy in the Col1a2(G610C) mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFβ signaling on trabecular bone but not on cortical bone.
Kaupp S, Horan DJ, Lim KE, Feldman HA, Robling AG, Warman ML, Jacobsen CM., Free PMC Article | 06/26/2021 |
| The restraining effect of miR-545-3p on osteogenesis is mediated via LRP5/Wnt/beta-catenin signaling. miR-545-3p is transcriptionally activated by SP1. | SP1-stimulated miR-545-3p inhibits osteogenesis via targeting LRP5-activated Wnt/beta-catenin signaling.
Li L, Qiu X, Sun Y, Zhang N, Wang L. | 05/30/2020 |
| Lrp5 and -6 are required for the self-renewal. | Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.
Liu J, Cui Z, Wang F, Yao Y, Yu G, Liu J, Cao D, Niu S, You M, Sun Z, Lian D, Zhao T, Kang Y, Zhao Y, Xue HH, Yu S., Free PMC Article | 05/16/2020 |
| Wnt/Lrp5 signaling in osteoclasts affects osteoclastogenesis and activity in female mice. | Induction of Lrp5 HBM-causing mutations in Cathepsin-K expressing cells alters bone metabolism.
Kang KS, Hong JM, Horan DJ, Lim KE, Bullock WA, Bruzzaniti A, Hann S, Warman ML, Robling AG., Free PMC Article | 02/22/2020 |
| loss of Lrp5, the co-receptor thought to transmit extracellular WNT signals during bone mass regulation, did not reduce the bone-anabolic effect of Wnt1, providing direct evidence that Wnt1 function does not require the LRP5 co-receptor. | Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand.
Luther J, Yorgan TA, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D, Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S, Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David JP. | 11/9/2019 |
| Anti-LRP5/LRP6 single-domain antibody fragments promote differentiation of Wnt3a-hypersensitive intestinal stem cells. | Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Fenderico N, van Scherpenzeel RC, Goldflam M, Proverbio D, Jordens I, Kralj T, Stryeck S, Bass TZ, Hermans G, Ullman C, Aastrup T, Gros P, Maurice MM., Free PMC Article | 02/9/2019 |
| Heterozygous deletion of the LRP5 gene in mice could alter the profile of the immune cells, influence the balance of immune environment, and modulate bone homeostasis. | Heterozygous deletion of LRP5 gene in mice alters profile of immune cells and modulates differentiation of osteoblasts.
Li L, Wang Y, Zhang N, Zhang Y, Lin J, Qiu X, Gui Y, Wang F, Li D, Wang L. | 10/27/2018 |
| Megakaryocytes are increased in the bone marrow of Lrp5G170V/G170V mice. Depletion of megakaryocytes does not affect the Lrp5-induced high bone mass. | The high bone mass phenotype of Lrp5-mutant mice is not affected by megakaryocyte depletion.
Yorgan T, David JP, Amling M, Schinke T. | 05/12/2018 |
| The phenotype of the Lrp5(tvrm111B) mutant includes abnormalities of the retinal vasculature and of bone mineral density. | A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density.
Charette JR, Earp SE, Bell BA, Ackert-Bicknell CL, Godfrey DA, Rao S, Anand-Apte B, Nishina PM, Peachey NS., Free PMC Article | 02/10/2018 |
| the LRP5 mutation in high bone mass transgenic mice shows altered bone matrix composition | HBM Mice Have Altered Bone Matrix Composition and Improved Material Toughness.
Ross RD, Mashiatulla M, Acerbo AS, Almer JD, Miller LM, Johnson ML, Sumner DR., Free PMC Article | 01/6/2018 |
| Lrp6 is the key mediator of Wnt3a signaling in osteoblasts and Lrp5 played a less significant role in mediating Wnt3a signaling. | Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.
Sebastian A, Hum NR, Murugesh DK, Hatsell S, Economides AN, Loots GG., Free PMC Article | 12/16/2017 |
| Identification of a link between Wnt-Lrp5 signaling and insulin signaling in the osteoblast that has the potential to influence energy balance and compound the detrimental effects of a HFD on whole-body metabolism. | Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism.
Kim SP, Frey JL, Li Z, Goh BC, Riddle RC., Free PMC Article | 12/16/2017 |
| Lrp5(-/-) mice displayed significantly delayed retinal vascular development, absence of deep layer retinal vessels, leading to increased levels of vascular endothelial growth factor and subsequent pathologic glomeruloid vessels, as well as decreased inner retinal visual function. | Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy.
Wang Z, Liu CH, Sun Y, Gong Y, Favazza TL, Morss PC, Saba NJ, Fredrick TW, He X, Akula JD, Chen J., Free PMC Article | 10/14/2017 |