| Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance. | Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance.
Cabral-Costa JV, Vicente-Gutiérrez C, Agulla J, Lapresa R, Elrod JW, Almeida Á, Bolaños JP, Kowaltowski AJ., Free PMC Article | 05/18/2023 |
| Essential role of the mitochondrial Na[+]/Ca[2+] exchanger NCLX in mediating PDE2-dependent neuronal survival and learning. | Essential role of the mitochondrial Na(+)/Ca(2+) exchanger NCLX in mediating PDE2-dependent neuronal survival and learning.
Rozenfeld M, Azoulay IS, Ben Kasus Nissim T, Stavsky A, Melamed M, Stutzmann G, Hershfinkel M, Kofman O, Sekler I., Free PMC Article | 12/17/2022 |
| The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes. | The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes.
Emrich SM, Yoast RE, Fike AJ, Bricker KN, Xin P, Zhang X, Rahman ZSM, Trebak M. | 12/10/2022 |
| The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma. | The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma.
Johnson MT, Benson JC, Pathak T, Xin P, McKernan AS, Emrich SM, Yoast RE, Walter V, Straub AC, Trebak M., Free PMC Article | 10/1/2022 |
| Enhanced NCLX-dependent mitochondrial Ca(2+) efflux attenuates pathological remodeling in heart failure. | Enhanced NCLX-dependent mitochondrial Ca(2+) efflux attenuates pathological remodeling in heart failure.
Garbincius JF, Luongo TS, Jadiya P, Hildebrand AN, Kolmetzky DW, Mangold AS, Roy R, Ibetti J, Nwokedi M, Koch WJ, Elrod JW., Free PMC Article | 05/21/2022 |
| Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation. | Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation.
Stavsky A, Stoler O, Kostic M, Katoshevsky T, Assali EA, Savic I, Amitai Y, Prokisch H, Leiz S, Daumer-Haas C, Fleidervish I, Perocchi F, Gitler D, Sekler I., Free PMC Article | 08/14/2021 |
| NCLX prevents cell death during adrenergic activation of the brown adipose tissue. | NCLX prevents cell death during adrenergic activation of the brown adipose tissue.
Assali EA, Jones AE, Veliova M, Acín-Pérez R, Taha M, Miller N, Shum M, Oliveira MF, Las G, Liesa M, Sekler I, Shirihai OS., Free PMC Article | 08/29/2020 |
| Results found that NCLX reduction/inhibition markedly suppressed chemotaxis while increasing the random migration of B lymphocytes. In addition, the contributions of NCLX to motility were observed only in B lymphocytes and not in T lymphocytes. | Roles of the mitochondrial Na(+)-Ca(2+) exchanger, NCLX, in B lymphocyte chemotaxis.
Kim B, Takeuchi A, Hikida M, Matsuoka S., Free PMC Article | 06/2/2018 |
| tamoxifen-induced deletion of Slc8b1 in adult mouse hearts causes sudden death, with less than 13% of affected mice surviving after 14 days; lethality correlated with severe myocardial dysfunction and fulminant heart failure | The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability.
Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, Elrod JW., Free PMC Article | 09/23/2017 |
| NCLX mediates the mitochondrial Na(+) influx and is tuned to sense the TTX-sensitive cytosolic Na(+) responses. | Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria.
Nita II, Hershfinkel M, Kantor C, Rutter GA, Lewis EC, Sekler I., Free PMC Article | 10/11/2014 |
| NCLX is a novel molecule to regulate automaticity of cardiomyocytes via modulating sarcoplasmic reticulum Ca(2+) handling. | The mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes.
Takeuchi A, Kim B, Matsuoka S., Free PMC Article | 05/3/2014 |
| Silencing of NCLX expression significantly reduces Ca2+-dependent processes in astrocytes. | Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes.
Parnis J, Montana V, Delgado-Martinez I, Matyash V, Parpura V, Kettenmann H, Sekler I, Nolte C., Free PMC Article | 06/29/2013 |
| The findings suggest that the mitochondrial Na(+)/Ca(2+) exchanger, NCLX, shapes glucose-dependent mitochondrial and cytosolic Ca(2+) signals thereby regulating the temporal pattern of insulin secretion in beta cells. | The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.
Nita II, Hershfinkel M, Fishman D, Ozeri E, Rutter GA, Sensi SL, Khananshvili D, Lewis EC, Sekler I., Free PMC Article | 05/4/2013 |
| Ca(2+) entering the myocyte via NCX can cause Ca(2+) sparks which are similar to those elicited by electrical stimulation. However, Ca(2+) influx on NCX is much less efficient in inducing Ca(2+) sparks than Ca(2+) influx via I(Ca,L). | Ca2+ sparks induced by Na/Ca exchange.
Ritter M, Sui Z, Philipson KD, Li F, Spitzer KW, Ishida H, Barry WH. | 01/21/2010 |
| data provide evidence for the presence of an electrogenic Na(+)/Ca(2+) exchanger that is capable of regulating [Ca(2+)](i) after release of Ca(2+) from cell stores | Regulation of intracellular calcium in N1E-115 neuroblastoma cells: the role of Na(+)/Ca(2+) exchange.
Kopper KL, Adorante JS. | 01/21/2010 |
| An electrophysiologically distinct subset of arcuate nucleus neurons coexpress orexin receptors and glutamate decarboxylase-67 and are excited by orexin, activating a sodium-calcium exchange current, thereby depolarizing the cell and increasing its firing | Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.
Burdakov D, Liss B, Ashcroft FM., Free PMC Article | 01/21/2010 |
| Presence of a Na(+)-Ca(2+) exchanger in podocytes and its regulation by PKC. | Characterization of a Na(+)-Ca(2+) exchanger in podocytes.
Fischer KG, Jonas N, Poschenrieder F, Cohen C, Kretzler M, Greiber S, Pavenstädt H. | 01/21/2010 |