| P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition. | P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition.
Valverde-Lopez JA, Li-Bao L, Sierra R, Santos E, Giovinazzo G, Díaz-Díaz C, Torres M., Free PMC Article | 04/10/2024 |
| Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice. | Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice.
Brennan MS, Brinkmann K, Romero Sola G, Healey G, Gibson L, Gangoda L, Potts MA, Lieschke E, Wilcox S, Strasser A, Herold MJ, Janic A., Free PMC Article | 02/12/2024 |
| Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia. | Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia.
Kennedy Ii DE, Mody P, Gout JF, Tan W, Seo KS, Olivier AK, Rosch JW, Thornton JA., Free PMC Article | 06/18/2022 |
| Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects. | Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects.
Bowen ME, Mulligan AS, Sorayya A, Attardi LD., Free PMC Article | 03/5/2022 |
| DNA repair in primordial follicle oocytes following cisplatin treatment. | DNA repair in primordial follicle oocytes following cisplatin treatment.
Nguyen QN, Zerafa N, Findlay JK, Hickey M, Hutt KJ., Free PMC Article | 12/11/2021 |
| PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis. | PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis.
Dang Y, Zhang Y, Xu L, Zhou X, Gu Y, Yu J, Jin S, Ji H, Shu Y, Zhang G, Cui S, Sun J., Free PMC Article | 03/13/2021 |
| IL-6-driven FasL promotes NF-kappaBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy. | IL-6-driven FasL promotes NF-κBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy.
Tan S, Xu M, Ke B, Lu Y, Liu H, Jiang J, Wu B., Free PMC Article | 08/22/2020 |
| RIP1/JNK-dependent-PUMA induction mediates acetaminophen-induced liver injury by promoting hepatocyte mitochondrial dysfunction and necrosis. | p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice.
Chen D, Ni HM, Wang L, Ma X, Yu J, Ding WX, Zhang L., Free PMC Article | 06/20/2020 |
| These studies identify PUMA as a crucial effector of apoptosis responsible for depletion of primordial follicles. | Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.
Nguyen QN, Zerafa N, Liew SH, Morgan FH, Strasser A, Scott CL, Findlay JK, Hickey M, Hutt KJ., Free PMC Article | 11/9/2019 |
| The study suggests that targeting MIAT may protect against cardiomyocytes against hypoxia-reperfusion injury or myocardial ischemia-reperfusion injury via inhibition of cell apoptosis, mediated by NF-kappaB and PUMA signaling pathway. | Targeting MIAT reduces apoptosis of cardiomyocytes after ischemia/reperfusion injury.
Chen L, Zhang D, Yu L, Dong H., Free PMC Article | 08/31/2019 |
| TFEB functions cell-autonomously through PUMA induction and Bax-Bak activation to promote programmed cell death of a subset of premyelinating oligodendrocytes, allowing selective elimination of oligodendrocytes in normally unmyelinated brain regions. | Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis.
Sun LO, Mulinyawe SB, Collins HY, Ibrahim A, Li Q, Simon DJ, Tessier-Lavigne M, Barres BA., Free PMC Article | 08/31/2019 |
| Using gain- and loss-of-function approaches, we identified a unique role of miR-143/PUMA in mediating microglial activation via regulation of NLRP3 inflammasome activation. | Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H. | 01/12/2019 |
| PUMA promotes the cytosolic release of mitochondrial DNA and activation of the DNA sensors DAI/Zbp1 and STING, leading to enhanced RIP3 and MLKL phosphorylation in a positive feedback loop. | PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.
Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L., Free PMC Article | 10/13/2018 |
| Expression from a luciferase reporter construct containing the 2 kb fragment of the promoter region of bcl-2-binding component 3 (PUMA) is enhanced by activation of the muscle regulatory transcription factor MyoD in both myoblasts and fibroblasts and diminishes by silencing of MyoD in myoblasts. E-Box Sequences at position - 857 of PUMA is the binding site for MyoD. | The muscle regulatory transcription factor MyoD participates with p53 to directly increase the expression of the pro-apoptotic Bcl2 family member PUMA.
Harford TJ, Kliment G, Shukla GC, Weyman CM., Free PMC Article | 07/21/2018 |
| Proapoptotic proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL. | The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.
Delbridge AR, Aubrey BJ, Hyland C, Bernardini JP, Di Rago L, Garnier JM, Lessene G, Strasser A, Alexander WS, Grabow S., Free PMC Article | 03/31/2018 |
| The mitochondrial apoptotic pathway, activated by BH3-only proteins, BIM and PUMA, is essential for endoplasmic reticulum stress-induced cell death; DR5 as well as caspase-8 are not required for this process. | DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.
Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H., Free PMC Article | 02/17/2018 |
| Mir143-BBC3 has roles in microglial survival in the context of drug abuse | Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H., Free PMC Article | 12/30/2017 |
| In the mouse model of silicosis, Bbc3 knockout mice clearly exhibited decreased levels of autophagy and fibrosis progression. These results suggest that downregulation of BBC3 expression may become a novel therapeutic strategy for the treatment of silicosis. | BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.
Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J, Liao H., Free PMC Article | 11/4/2017 |
| This study has demonstrated that methamphetamine-mediated pericytes migration involves PUMA up-regulation. | Involvement of PUMA in pericyte migration induced by methamphetamine.
Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, Yao H. | 09/30/2017 |
| Data show that Emu-Myc mice lacking both p21 and PUMA developed lymphoma at a rate considerably longer latency than Emu-Myc;p53(+/-)mice. | Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53.
Valente LJ, Grabow S, Vandenberg CJ, Strasser A, Janic A. | 09/16/2017 |
| Our data show a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic host cell death during Listeria infection. | Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection.
Margaroli C, Oberle S, Lavanchy C, Scherer S, Rosa M, Strasser A, Pellegrini M, Zehn D, Acha-Orbea H, Ehirchiou D. | 07/1/2017 |
| Overexpression of miR-29 or miR-24 is sufficient to inhibit the induction of Bim and Puma in young sympathetic neurons. | Mature neurons dynamically restrict apoptosis via redundant premitochondrial brakes.
Annis RP, Swahari V, Nakamura A, Xie AX, Hammond SM, Deshmukh M., Free PMC Article | 07/1/2017 |
| loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL. It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL with BAK and BAX. | Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).
Delbridge AR, Chappaz S, Ritchie ME, Kile BT, Strasser A, Grabow S. | 05/20/2017 |
| PUMA is dispensable for glucose homeostasis in lean and obese mice, but it can affect leptin levels and food intake during obesity. | p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.
Litwak SA, Loh K, Stanley WJ, Pappas EG, Wali JA, Selck C, Strasser A, Thomas HE, Gurzov EN., Free PMC Article | 02/18/2017 |
| MYSM1 is a critical negative regulator of p53 transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cel function. | Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Belle JI, Petrov JC, Langlais D, Robert F, Cencic R, Shen S, Pelletier J, Gros P, Nijnik A., Free PMC Article | 12/31/2016 |