| Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5. | Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS., Free PMC Article | 01/6/2018 |
| We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier. | Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier.
Dohgu S, Ryerse JS, Robinson SM, Banks WA., Free PMC Article | 03/23/2013 |
| Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice | Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.
Chavele KM, Martinez-Pomares L, Domin J, Pemberton S, Haslam SM, Dell A, Cook HT, Pusey CD, Gordon S, Salama AD., Free PMC Article | 05/31/2010 |
| the alpha-galactosidase enzyme is incorporated via cation-independent mannose 6-phosphate receptors in Schwann cells | Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant alpha-galactosidase.
Kawashima I, Watabe K, Tajima Y, Fukushige T, Kanzaki T, Kanekura T, Sugawara K, Ohyanagi N, Suzuki T, Togawa T, Sakuraba H. | 01/21/2010 |
| epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase across the blood brain barrier in adults to levels seen in the neonate | Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor.
Urayama A, Grubb JH, Banks WA, Sly WS., Free PMC Article | 01/21/2010 |
| Data characterize the retrograde transport of mannose 6-phosphate receptor MPR46 from endosomes to the trans-Golgi network by an in vitro transport assay using mouse fibroblast cell lines. | Characterization of the in vitro retrograde transport of MPR46.
Medigeshi GR, Schu P. | 01/21/2010 |
| The murine 46-kDa mannose 6-phosphate receptor has the capacity to deliver its cargo proteins to lysosomes even in the absence of endosomal acidification. | The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes.
Probst OC, Ton P, Svoboda B, Gannon A, Schuhmann W, Wieser J, Pohlmann R, Mach L. | 01/21/2010 |
| there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B | Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
Dressel R, Raja SM, Höning S, Seidler T, Froelich CJ, von Figura K, Günther E. | 01/21/2010 |
| Mannose 6-phosphate receptor has a role in acid sphingomyelinase deficiency | Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: implications for Niemann-Pick disease enzyme replacement therapy.
Dhami R, Schuchman EH. | 01/21/2010 |
| These results indicate that beta-glucuronidase transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor. | Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier.
Urayama A, Grubb JH, Sly WS, Banks WA., Free PMC Article | 01/21/2010 |
| in hepatocytes of MPR-deficient neonatal mice lysosomal storage occurs when both MPRs are lacking, whereas deficiency of CI-MPR only has no effect on the ultrastructure of the lysosomal system. | Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice.
Schellens JP, Saftig P, von Figura K, Everts V. | 01/21/2010 |
| Mpr46 is dispensable on target cells for lysis and apoptosis mediated by alloreactive cytotoxic T lymphocytes. | Unimpaired allorejection of cells deficient for the mannose 6-phosphate receptors Mpr300 and Mpr46.
Dressel R, von Figura K, Günther E. | 01/21/2010 |