| Suppression of HCN channels in the spinal dorsal horn restores KCC2 expression and attenuates diabetic neuropathic pain. | Suppression of HCN channels in the spinal dorsal horn restores KCC2 expression and attenuates diabetic neuropathic pain.
Ma Y, Chen J, Chen C, Wei B, Liu X. | 02/12/2024 |
| NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons. | NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons.
Pol E, Côme E, Merlaud Z, Gouhier J, Russeau M, Scotto-Lomassese S, Moutkine I, Marques X, Lévi S., Free PMC Article | 11/2/2023 |
| Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF. | Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF.
Calvo PM, de la Cruz RR, Pastor AM, Alvarez FJ., Free PMC Article | 05/18/2023 |
| Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats. | Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats.
Korlatowicz A, Pabian P, Solich J, Kolasa M, Latocha K, Dziedzicka-Wasylewska M, Faron-Górecka A., Free PMC Article | 01/28/2023 |
| The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. | The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism.
Haratizadeh S, Ranjbar M, Darvishzadeh-Mahani F, Basiri M, Nozari M. | 01/14/2023 |
| Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through alpha7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats. | Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats.
Jia D, Liu G, Sun Y, Hu Z, Huang Z, Huang C. | 12/24/2022 |
| Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1beta/KCC2 signaling during early development. | Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development.
Zhang D, Yang Y, Yang Y, Liu J, Zhu T, Huang H, Zhou C., Free PMC Article | 07/30/2022 |
| Partial ablation of frontal cortical subplate leads to developmental abnormalities in KCC2 in the prefrontal cortex. | Partial ablation of frontal cortical subplate leads to developmental abnormalities in KCC2 in the prefrontal cortex.
Lee KG, Rajakumar N. | 06/11/2022 |
| Hippocampal chloride transporter KCC2 contributes to excitatory GABA dysregulation in the developmental rat model of schizophrenia. | Hippocampal chloride transporter KCC2 contributes to excitatory GABA dysregulation in the developmental rat model of schizophrenia.
Atefimanash P, Pourhamzeh M, Susanabadi A, Arabi M, Jamali-Raeufy N, Mehrabi S. | 04/2/2022 |
| Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons. | Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons.
Al Awabdh S, Donneger F, Goutierre M, Séveno M, Vigy O, Weinzettl P, Russeau M, Moutkine I, Lévi S, Marin P, Poncer JC., Free PMC Article | 02/19/2022 |
| Rehabilitation Decreases Spasticity by Restoring Chloride Homeostasis through the Brain-Derived Neurotrophic Factor-KCC2 Pathway after Spinal Cord Injury. | Rehabilitation Decreases Spasticity by Restoring Chloride Homeostasis through the Brain-Derived Neurotrophic Factor-KCC2 Pathway after Spinal Cord Injury.
Beverungen H, Klaszky SC, Klaszky M, Côté MP., Free PMC Article | 08/14/2021 |
| Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus. | Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus.
Dumon C, Belaidouni Y, Diabira D, Appleyard SM, Wayman GA, Gaiarsa JL., Free PMC Article | 08/7/2021 |
| Coordinated downregulation of KCC2 and GABAA receptor contributes to inhibitory dysfunction during seizure induction. | Coordinated downregulation of KCC2 and GABA(A) receptor contributes to inhibitory dysfunction during seizure induction.
Wan L, Chen L, Yu J, Wang G, Wu Z, Qian B, Liu X, Wang Y. | 03/20/2021 |
| NR2B receptor- and calpain-mediated KCC2 cleavage resulted in cognitive deficiency exposure to isoflurane. | NR2B receptor- and calpain-mediated KCC2 cleavage resulted in cognitive deficiency exposure to isoflurane.
Tang X, Zhang X, Li S, Chi X, Luo A, Zhao Y. | 01/23/2021 |
| KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels. | KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.
Goutierre M, Al Awabdh S, Donneger F, François E, Gomez-Dominguez D, Irinopoulou T, Menendez de la Prida L, Poncer JC. | 08/29/2020 |
| Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. | Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
Mapplebeck JCS, Lorenzo LE, Lee KY, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW. | 08/29/2020 |
| Chloride extrusion by KCC2 is involved in modulation of giant depolarizing potentials already at their developmental onset during the perinatal period in mice and rats. | KCC2-Mediated Cl(-) Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Spoljaric I, Spoljaric A, Mavrovic M, Seja P, Puskarjov M, Kaila K., Free PMC Article | 03/14/2020 |
| KCC2 regulates dendritic spine formation in a brain-region specific and BDNF dependent manner. | KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner.
Awad PN, Amegandjin CA, Szczurkowska J, Carriço JN, Fernandes do Nascimento AS, Baho E, Chattopadhyaya B, Cancedda L, Carmant L, Di Cristo G., Free PMC Article | 12/21/2019 |
| Five weeks post-incomplete cervical contusion: 1) neither membrane-bound nor cytosolic NKCC1 expression were significantly changed, although the membrane/cytosolic ratio increased, consistent with net chloride influx; and 2) both membrane and cytosolic KCC2 expression increased, although the membrane/cytosolic ratio decreased, consistent with net chloride efflux. | Cervical spinal contusion alters Na(+)-K(+)-2Cl- and K(+)-Cl- cation-chloride cotransporter expression in phrenic motor neurons.
Allen LL, Seven YB, Baker TL, Mitchell GS., Free PMC Article | 04/6/2019 |
| Chloride co-transporters, NKCC1 (Na+-K+-Cl- co-transporter-1) and KCC2 (K+-Cl- co-transporter-2) control the intracellular concentration of chloride ions and thus the functionality of GABA inhibitions. | Increase of KCC2 in hippocampal synaptic plasticity disturbances after perinatal ethanol exposure.
Silvestre de Ferron B, Vilpoux C, Kervern M, Robert A, Antol J, Naassila M, Pierrefiche O. | 07/21/2018 |
| These findings suggest that PRF might be an alternative therapy for inflammatory pain. One of the underlying mechanisms is through modification of KCC2, which is an important determinant for the efficacy of inhibitory neurotransmission in the spinal cord, and its expression levels are regulated by histone acetylation epigenetically following inflammation. | Pulsed Radiofrequency Attenuates Complete Freund's Adjuvant-Induced Epigenetic Suppression of Potassium Chloride Cotransporter 2 Expression.
Liu CK, Liao WT, Chu YC, Yang CH, Chen KH, Wu CH, Lin CR. | 03/24/2018 |
| demonstrate that KCC2 overexpression in a compromised developing brain increases febrile seizure susceptibility and contribute to dendritic spine alterations | Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures.
Awad PN, Sanon NT, Chattopadhyaya B, Carriço JN, Ouardouz M, Gagné J, Duss S, Wolf D, Desgent S, Cancedda L, Carmant L, Di Cristo G. | 02/24/2018 |
| We demonstrate that GABABR activation can regulate KCC2 at the cell surface in a manner that alters intracellular chloride and the reversal potential for the GABAAR. Our data therefore support an additional mechanism by which GABABRs are able to modulate fast synaptic inhibition. | Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA(B) Receptor Protein Complex.
Wright R, Newey SE, Ilie A, Wefelmeyer W, Raimondo JV, Ginham R, Mcllhinney RAJ, Akerman CJ., Free PMC Article | 08/26/2017 |
| Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals. Early enrichment and IGF-1 administration produced a decrease in the ratio between NKCC1 and KCC2 cation/chloride transporters, suggesting that enrichment, via IGF-1, may hasten the developmental switch of neuronal GABAergic responses from excitation to inhibition. | Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals.
Baroncelli L, Cenni MC, Melani R, Deidda G, Landi S, Narducci R, Cancedda L, Maffei L, Berardi N. | 07/1/2017 |
| Findings suggest that aberrant regulation of the plasma membrane levels of KCC2 might contribute to the impartment of GABAergic neurotransmission and that KCC2 dysfunction might be relevant for the initial appearance of spontaneous seizures. | Regulation of the cell surface expression of chloride transporters during epileptogenesis.
González MI., Free PMC Article | 06/24/2017 |