| ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis. | ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Wan TT, Li Y, Li JX, Xiao X, Liu L, Li HH, Guo SB. | 02/1/2024 |
| Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice. | Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Takeshita H, Yamamoto K, Mogi M, Wang Y, Nozato Y, Fujimoto T, Yokoyama S, Hongyo K, Nakagami F, Akasaka H, Takami Y, Takeya Y, Sugimoto K, Horiuchi M, Rakugi H., Free PMC Article | 10/30/2021 |
| Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy. | Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
Ni J, Yang F, Huang XR, Meng J, Chen J, Bader M, Penninger JM, Fung E, Yu XQ, Lan HY., Free PMC Article | 06/19/2021 |
| Genetic deletion of the angiotensin-(1-7) receptor Mas leads to alterations in gut villi length modulating TLR4/PI3K/AKT and produces microbiome dysbiosis. | Genetic deletion of the angiotensin-(1-7) receptor Mas leads to alterations in gut villi length modulating TLR4/PI3K/AKT and produces microbiome dysbiosis.
Oliveira LP, Guimarães VHD, Oliveira JR, Guimarães ALS, de Paula AMB, Bader M, Santos RASD, Santos SHS. | 06/5/2021 |
| Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism. | Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism.
Song LN, Liu JY, Shi TT, Zhang YC, Xin Z, Cao X, Yang JK. | 04/24/2021 |
| Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle. | Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle.
Rivera JC, Abrigo J, Tacchi F, Simon F, Brandan E, Santos RA, Bader M, Chiong M, Cabello-Verrugio C., Free PMC Article | 03/6/2021 |
| Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation. | Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
Erfinanda L, Ravindran K, Kohse F, Gallo K, Preissner R, Walther T, Kuebler WM. | 02/2/2021 |
| study demonstrates that the activation of MAS is important for microglia recruitment and vascular growth in the developing retina. | The role of receptor MAS in microglia-driven retinal vascular development.
Foulquier S, Caolo V, Swennen G, Milanova I, Reinhold S, Recarti C, Alenina N, Bader M, Steckelings UM, Vanmierlo T, Post MJ, Jones EA, van Oostenbrugge RJ, Unger T., Free PMC Article | 07/4/2020 |
| MasR deficiency did not influence body weight, systolic blood pressure at baseline and during AngII infusion, or serum cholesterol concentrations in either Apoe-/- or Ldlr-/- mice. MasR deficiency increased AngII-induced atherosclerosis in aortic arches of Ldlr-/- mice associated with increased oxidative stress and apoptosis in aortic root sections. | Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
Stegbauer J, Thatcher SE, Yang G, Bottermann K, Rump LC, Daugherty A, Cassis LA., Free PMC Article | 05/30/2020 |
| Ang-(1-7) stimulates beige markers and thermogenesis via the Mas receptor. | Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.
Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, Schcolnik-Cabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R, Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR. | 05/2/2020 |
| Lack of the Mas receptor may have a protective effect against chronic brain ischemia when the Ang II type 2 receptor exists. | Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor.
Higaki A, Mogi M, Iwanami J, Min LJ, Bai HY, Shan BS, Kukida M, Yamauchi T, Tsukuda K, Kan-No H, Ikeda S, Higaki J, Horiuchi M., Free PMC Article | 12/14/2019 |
| The reduction of ovulatory rate highlights the relevance of Ang-(1-7)/Mas axis in female reproduction, probably through a reduction of IGF-1 mRNA levels. | Genetic deletion of the Angiotensin-(1-7) receptor Mas leads to a reduced ovulatory rate.
Honorato-Sampaio K, Andrade RF, Bader M, Martins AS, Santos RAS, Reis AM. | 07/20/2019 |
| These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2-Ang(17)-Mas axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB signaling pathway | Angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinase/nuclear factor-κB pathway.
Yu X, Cui L, Hou F, Liu X, Wang Y, Wen Y, Chi C, Li C, Liu R, Yin C. | 07/14/2018 |
| important factor in macrophage function during inflammation of the central nervous and vascular system | Role of the receptor Mas in macrophage-mediated inflammation in vivo.
Hammer A, Yang G, Friedrich J, Kovacs A, Lee DH, Grave K, Jörg S, Alenina N, Grosch J, Winkler J, Gold R, Bader M, Manzel A, Rump LC, Müller DN, Linker RA, Stegbauer J., Free PMC Article | 04/7/2018 |
| This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney. | Sex chromosome complement involvement in angiotensin receptor sexual dimorphism.
Dadam FM, Cisternas CD, Macchione AF, Godino A, Antunes-Rodrigues J, Cambiasso MJ, Vivas LM, Caeiro XE. | 11/26/2017 |
| MasR deficiency abolishes protection of female mice from obesity-induced hypertension | Differential effects of Mas receptor deficiency on cardiac function and blood pressure in obese male and female mice.
Wang Y, Shoemaker R, Powell D, Su W, Thatcher S, Cassis L., Free PMC Article | 07/29/2017 |
| Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala. | Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.
Wang L, de Kloet AD, Pati D, Hiller H, Smith JA, Pioquinto DJ, Ludin JA, Oh SP, Katovich MJ, Frazier CJ, Raizada MK, Krause EG., Free PMC Article | 06/24/2017 |
| impairment of the ANG-(1-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma. | Chronic allergic pulmonary inflammation is aggravated in angiotensin-(1-7) Mas receptor knockout mice.
Magalhães GS, Rodrigues-Machado MG, Motta-Santos D, Alenina N, Bader M, Santos RA, Barcelos LS, Campagnole-Santos MJ. | 06/24/2017 |
| The data indicate a significant function of Ang-(1-7) in the regulation of insulin secretion from mouse islets in vitro and in vivo, mainly, but not exclusively, by Mas-dependent signaling, modulating the accessory pathway of insulin secretion via increase in cAMP. | The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo.
Sahr A, Wolke C, Maczewsky J, Krippeit-Drews P, Tetzner A, Drews G, Venz S, Gürtler S, van den Brandt J, Berg S, Döring P, Dombrowski F, Walther T, Lendeckel U. | 05/27/2017 |
| This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR. | Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury.
Ali Q, Dhande I, Samuel P, Hussain T., Free PMC Article | 04/22/2017 |
| Ang-(1-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate. | Increased vascular sympathetic modulation in mice with Mas receptor deficiency.
Rabello Casali K, Ravizzoni Dartora D, Moura M, Bertagnolli M, Bader M, Haibara A, Alenina N, Irigoyen MC, Santos RA., Free PMC Article | 01/14/2017 |
| Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress. | Mas receptor mediates cardioprotection of angiotensin-(1-7) against Angiotensin II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.
Lin L, Liu X, Xu J, Weng L, Ren J, Ge J, Zou Y., Free PMC Article | 01/14/2017 |
| MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS axis functionality | MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality.
Pernomian L, do Prado AF, Gomes MS, Pernomian L, da Silva CHTP, Gerlach RF, de Oliveira AM. | 07/30/2016 |
| Mas receptor deficiency results in exacerbated inflammation in LPS-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS. | Mas receptor deficiency exacerbates lipopolysaccharide-induced cerebral and systemic inflammation in mice.
Oliveira-Lima OC, Pinto MC, Duchene J, Qadri F, Souza LL, Alenina N, Bader M, Santos RA, Carvalho-Tavares J. | 07/16/2016 |
| a Mas receptor-mediated mechanism may stimulate pancreatic cell development | The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos.
Wang L, Liang J, Leung PS., Free PMC Article | 04/16/2016 |