| Effect of DIO2 Gene Polymorphism on Thyroid Hormone Levels and Its Correlation with the Severity of Schizophrenia in a Pakistani Population. | Effect of DIO2 Gene Polymorphism on Thyroid Hormone Levels and Its Correlation with the Severity of Schizophrenia in a Pakistani Population.
Hanif F, Amir Q, Washdev W., Free PMC Article | 02/28/2024 |
| Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank. | Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank.
Jensen CZ, Isaksen JL, Ahlberg G, Olesen MS, Nygaard B, Ellervik C, Kanters JK. | 01/26/2024 |
| Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers. | Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers.
Rybicka M, Verrier ER, Baumert TF, Bielawski KP., Free PMC Article | 04/19/2023 |
| Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study. | Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study.
Kang YM, Koo BS, Yi HS, Kim JT, Park B, Lee JH, Shong M, Kang YE., Free PMC Article | 03/27/2023 |
| Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions. | Single-cell profiling of the microenvironment in decidual tissue from women with missed abortions.
Hou R, Huang R, Zhou Y, Lin D, Xu J, Yang L, Wei X, Xie Z, Zhou Q. | 03/7/2023 |
| Association between phenols and thyroid hormones: The role of iodothyronine deiodinase genes. | Association between phenols and thyroid hormones: The role of iodothyronine deiodinase genes.
Sarzo B, Abumallouh R, Marín N, Llop S, Beneito A, Lopez-Flores I, Ferrero N, Sakhi AK, Ballester F, Lopez-Espinosa MJ. | 09/24/2022 |
| Type 2 deiodinase p.Thr92Ala polymorphism does not affect the severity of obesity and weight loss after bariatric surgery. | Type 2 deiodinase p.Thr92Ala polymorphism does not affect the severity of obesity and weight loss after bariatric surgery.
Benenati N, Bufano A, Cantara S, Ricci C, Marzocchi C, Ciuoli C, Sannino I, Tirone A, Voglino C, Vuolo G, Castagna MG., Free PMC Article | 07/2/2022 |
| Crosstalk between CpG Methylation and Polymorphisms (CpG-SNPs) in the Promotor Region of DIO2 in Kashin-Beck Disease. | Crosstalk between CpG Methylation and Polymorphisms (CpG-SNPs) in the Promotor Region of DIO2 in Kashin-Beck Disease.
Zhang RQ, Zhang DD, Zhang D, Yang XL, Li Q, Wang C, Yang XN, Xiong YM. | 05/14/2022 |
| Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the DIO2, GPX3, and TXRND1 Promoter Regions. | Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the DIO2, GPX3, and TXRND1 Promoter Regions.
Zhang R, Guo H, Yang X, Zhang D, Zhang D, Li Q, Wang C, Yang X, Xiong Y., Free PMC Article | 04/2/2022 |
| Iodothyronine deiodinase 2 (DiO2) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage. | Iodothyronine deiodinase 2 (DiO(2)) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage.
Adu-Gyamfi EA, Lamptey J, Chen XM, Li FF, Li C, Ruan LL, Yang XN, Liu TH, Wang YX, Ding YB. | 02/5/2022 |
| The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis. | The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis.
Wang X, Chen K, Zhang C, Wang H, Li J, Wang C, Teng W, Shan Z, Lai Y., Free PMC Article | 01/15/2022 |
| Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism. | Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism.
E Marcondes AA, Gomez TGB, Ravache TT, Batistuzzo A, Lorena FB, de Paula CS, Lowenthal R, Bianco AC, Ribeiro MO., Free PMC Article | 12/25/2021 |
| The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves' disease treatment. | The polymorphic inheritance of DIO2 rs225014 may predict body weight variation after Graves' disease treatment.
Comarella AP, Vilagellin D, Bufalo NE, Euflauzino JF, de Souza Teixeira E, Miklos ABPP, Dos Santos RB, Romaldini JH, Ward LS., Free PMC Article | 11/22/2021 |
| Deiodinases and the Metabolic Code for Thyroid Hormone Action. | Deiodinases and the Metabolic Code for Thyroid Hormone Action.
Russo SC, Salas-Lucia F, Bianco AC., Free PMC Article | 10/23/2021 |
| Type 2 deiodinase Thr92Ala polymorphism is associated with a reduction in bone mineral density: A community-based korean genome and epidemiology study. | Type 2 deiodinase Thr92Ala polymorphism is associated with a reduction in bone mineral density: A community-based korean genome and epidemiology study.
Kang YE, Kang YM, Park B, Shong M, Yi HS. | 09/18/2021 |
| Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective. | Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective.
Ricci C, Kakularam KR, Marzocchi C, Capecchi G, Riolo G, Boschin F, Kuhn H, Castagna MG, Cantara S. | 08/28/2021 |
| Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits. | Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits.
Uter JC, Krämer UM, Schöls L, Rodriguez-Fornells A, Göbel A, Heldmann M, Lichtner P, Brabant G, Münte TF. | 06/5/2021 |
| High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus. | High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus.
Gutiérrez-Vega S, Armella A, Mennickent D, Loyola M, Covarrubias A, Ortega-Contreras B, Escudero C, Gonzalez M, Alcalá M, Ramos MDP, Viana M, Castro E, Leiva A, Guzmán-Gutiérrez E., Free PMC Article | 01/9/2021 |
| The results obtained in the present study indicate that DIO2 polymorphisms rs1352815 and rs1388382 were correlated with KBD susceptibility among Tibetans, which also sheds new light on the role of DIO2 in the development of KBD. | Association between DIO2 polymorphism and the risk of Kashin-Beck disease in the Tibetan population.
Jin T, Wang L, He X, Liu M, Bai M, Rong H, He Y, Yuan D. | 07/18/2020 |
| Our results indicate that increased thyroidal D1 and D2 activities may be responsible for the higher serum FT3/FT4 ratio in patients with huge goitrous Hashimoto's thyroiditis. | Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with huge goitrous Hashimoto's thyroiditis.
Harada A, Nomura E, Nishimura K, Ito M, Yoshida H, Miyauchi A, Nishikawa M, Shiojima I, Toyoda N. | 05/23/2020 |
| 5730A>T mutation of DIO2 decreased selenocysteine-insertion sequence element read-through by 75% | Functional Analysis of Genetic Variation in the SECIS Element of Thyroid Hormone Activating Type 2 Deiodinase.
Zevenbergen C, Groeneweg S, Swagemakers SMA, de Jong A, Medici-Van den Herik E, Rispens M, Klootwijk W, Medici M, de Rijke YB, Meima ME, Larsen PR, Chavatte L, Venter D, Peeters RP, Van der Spek PJ, Visser WE. | 02/29/2020 |
| This study demonstrated that DIO2 levels were higher in the patients with chronic obstructive pulmonary disease than in the control subjects. | Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population.
Gałecka E, Kumor-Kisielewska A, Górski P. | 12/14/2019 |
| TSHR mutations along with DIO2 T92A SNP ("double hit") may lead to a significant reduction in DIO2 activity stimulated by TSH, and thereby may have clinical relevance in a select population of hypothyroidism patients who might benefit from a T3/T4 combination therapy. | Concurrent TSHR mutations and DIO2 T92A polymorphism result in abnormal thyroid hormone metabolism.
Park E, Jung J, Araki O, Tsunekawa K, Park SY, Kim J, Murakami M, Jeong SY, Lee S., Free PMC Article | 10/12/2019 |
| D2-Thr92Ala polymorphism in hypothyroid patients can be related to lower levels of intracellular T3 and consequently to a peripheral hypothyroidism. D2-Thr92Ala polymorphism has been related to more severe type 2 diabetes. [review] | Clinical significance of type 2 iodothyronine deiodinase polymorphism.
Maino F, Cantara S, Forleo R, Pilli T, Castagna MG. | 09/28/2019 |
| DIO2 catalytic activity is lower in carriers of Thr92Ala polymorphism, who also exhibit localized or systemic hypothyroidism. DIO2 Thr92Ala also localizes abnormally to the Golgi apparatus. African American carriers of Thr92Ala-DIO2 exhibit an about 30% higher risk of developing Alzheimer's disease. | Pathophysiological relevance of deiodinase polymorphism.
Bianco AC, Kim BS., Free PMC Article | 09/7/2019 |