| Role of neutrophil myeloperoxidase in the development and progression of high-altitude pulmonary edema. | Role of neutrophil myeloperoxidase in the development and progression of high-altitude pulmonary edema.
Zhang H, Wang X, Liu J, Zhang Y, Ka M, Ma Y, Xu J, Zhang W. | 03/15/2024 |
| Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer. | Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer.
Basnet A, Landreth KM, Nohoesu R, Santiago SP, Geldenhuys WJ, Boone BA, Liu TW., Free PMC Article | 02/21/2024 |
| Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma. | Myeloperoxidase creates a permissive microenvironmental niche for the progression of multiple myeloma.
Williams CMD, Noll JE, Bradey AL, Duggan J, Wilczek VJ, Masavuli MG, Grubor-Bauk B, Panagopoulos RA, Hewett DR, Mrozik KM, Zannettino ACW, Vandyke K, Panagopoulos V., Free PMC Article | 11/20/2023 |
| Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy. | Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
Nettersheim FS, Schlüter JD, Kreuzberg W, Mehrkens D, Grimm S, Nemade H, Braumann S, Hof A, Guthoff H, Peters V, Hoyer FF, Kargapolova Y, Lackmann JW, Müller S, Pallasch CP, Hallek M, Sachinidis A, Adam M, Winkels H, Baldus S, Geißen S, Mollenhauer M., Free PMC Article | 09/20/2023 |
| Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice. | Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice.
Oriá RB, Costa DVS, de Medeiros PHQS, Roque CR, Dias RP, Warren CA, Bolick DT, Guerrant RL., Free PMC Article | 06/13/2023 |
| NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease. | NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.
Boonpraman N, Yoon S, Kim CY, Moon JS, Yi SS., Free PMC Article | 05/17/2023 |
| Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma. | Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma.
Liu TW, Gammon ST, Yang P, Ma W, Wang J, Piwnica-Worms D., Free PMC Article | 02/23/2023 |
| Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms. | Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms.
Kongkiatkamon S, Terkawi L, Guan Y, Adema V, Hasipek M, Dombrovski T, Co M, Walter W, Awada H, Parker Y, Hutter S, Pagliuca S, Gurnari C, Rogers HJ, Meggendorfer M, Lindner DJ, Haferlach T, Visconte V, LaFramboise T, Jha BK, Maciejewski JP. | 08/6/2022 |
| Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. | Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.
Smyth LCD, Murray HC, Hill M, van Leeuwen E, Highet B, Magon NJ, Osanlouy M, Mathiesen SN, Mockett B, Singh-Bains MK, Morris VK, Clarkson AN, Curtis MA, Abraham WC, Hughes SM, Faull RLM, Kettle AJ, Dragunow M, Hampton MB., Free PMC Article | 05/7/2022 |
| Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro. | Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro.
Goeritzer M, Bernhart E, Plastira I, Reicher H, Leopold C, Eichmann TO, Rechberger G, Madreiter-Sokolowski CT, Prasch J, Eller P, Graier WF, Kratky D, Malle E, Sattler W., Free PMC Article | 11/21/2020 |
| The study showed that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO(-/-)), there was decreased cell loss, including degenerating neurons and oligodendrocytes, in the ischemic brains compared to vehicle-treated WT mice after stroke. | Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke.
Kim HJ, Wei Y, Wojtkiewicz GR, Lee JY, Moskowitz MA, Chen JW., Free PMC Article | 05/30/2020 |
| These data suggest that MPO inhibition does not alter atherosclerotic plaque area or leukocyte homing, but rather alters the inflammatory tone of atherosclerotic lesions; thus, MPO inhibition could have utility to promote atherosclerotic lesion stabilization and prevent atherosclerotic plaque rupture. | Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition.
Roth Flach RJ, Su C, Bollinger E, Cortes C, Robertson AW, Opsahl AC, Coskran TM, Maresca KP, Keliher EJ, Yates PD, Kim AM, Kalgutkar AS, Buckbinder L., Free PMC Article | 12/14/2019 |
| MPO, via ionic interaction with heparan sulfate side chains, can cause neutrophil-dependent Sdc1 shedding and collapse of the endothelial glycocalyx structure. | MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge.
Manchanda K, Kolarova H, Kerkenpaß C, Mollenhauer M, Vitecek J, Rudolph V, Kubala L, Baldus S, Adam M, Klinke A. | 07/27/2019 |
| Severe clinical and pathological disease is associated with the induction of anti-MPO IgG/LPS-mediated glomerulonephritis. | Age-determined severity of anti-myeloperoxidase autoantibody-mediated glomerulonephritis in mice.
Wang Q, van Timmeren MM, Petersen AH, Yuan J, Moser J, Brouwer E, Westra J, Boots AM, Heeringa P. | 04/14/2018 |
| this study demonstrated for the first time the involvement of striatal delta-ALA-D activity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and its correlation with the MPO activity. | δ-Aminolevulinate Dehydratase Activity is Stimulated in a MPTP Mouse Model of Parkinson's Disease: Correlation with Myeloperoxidase Activity.
Sampaio TB, Marcondes Sari MH, Pesarico AP, Nogueira CW. | 02/24/2018 |
| These studies further support involvement of MPO-catalyzed oxidative processes in both the development of atherosclerosis and diabetes risk | Myeloperoxidase-mediated protein lysine oxidation generates 2-aminoadipic acid and lysine nitrile in vivo.
Lin H, Levison BS, Buffa JA, Huang Y, Fu X, Wang Z, Gogonea V, DiDonato JA, Hazen SL., Free PMC Article | 12/16/2017 |
| Neutrophils are abundant in abdominal aortic aneurysm (AAA), and myeloperoxidase (MPO), prominently expressed in neutrophils, is associated with AAA. taurine, which can scavenge MPO-generated oxidants, can prevent AAA formation. | Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine.
Kim HW, Blomkalns AL, Ogbi M, Thomas M, Gavrila D, Neltner BS, Cassis LA, Thompson RW, Weiss RM, Lindower PD, Blanco VM, McCormick ML, Daugherty A, Fu X, Hazen SL, Stansfield BK, Huo Y, Fulton DJ, Chatterjee T, Weintraub NL., Free PMC Article | 12/16/2017 |
| PTX3 attenuates the production of murine myeloperoxidase-anti-neutrophil cytoplasmic antibody induced by aluminum salt adjuvant. | Involvement of pentraxin-3 in anti-neutrophil cytoplasmic antibody production induced by aluminum salt adjuvant.
Nagai K, Aratani Y, Shibuya A, Yamagata K. | 11/25/2017 |
| There is a smaller number of MPO positive neutrophils in the inflammatory infiltrate of a resistant model of amoebic liver abscess. | Different behavior of myeloperoxidase in two rodent amoebic liver abscess models.
Cruz-Baquero A, Cárdenas Jaramillo LM, Gutiérrez-Meza M, Jarillo-Luna RA, Campos-Rodríguez R, Rivera-Aguilar V, Miliar-García A, Pacheco-Yepez J., Free PMC Article | 10/7/2017 |
| thisa study shows that neutrophil myeloperoxidase plays a paradoxical role in bacterial clearance and tissue damage in pneumococcal acute otitis media | The critical role of myeloperoxidase in Streptococcus pneumoniae clearance and tissue damage during mouse acute otitis media.
Xiang Y, Jin C, Wang W, Wang Z, Huang Y, Fan F, Ma Y, Zhang X, Xu W, Yin Y, He Y. | 07/1/2017 |
| lung MPO activity increased following induction of sepsis with CLP while siRNA treatment significantly reduced MPO activity. Liver and lung cytokine and chemokine levels in CLP-induced sepsis reduced following treatment with siRNA. These findings show a crucial pro-inflammatory role for H2S synthesized by CSE in macrophages in sepsis and suggest CSE gene silencing with siRNA as a potential therapeutic approach for this co | Cystathionine-γ-lyase gene silencing with siRNA in monocytes/ macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse.
Badiei A, Chambers ST, Gaddam RR, Bhatia M. | 12/17/2016 |
| MPO deficiency upregulates the expression of several proinflammatory cytokines and chemokines in mouse neutrophils | Myeloperoxidase negatively regulates the expression of proinflammatory cytokines and chemokines by zymosan-induced mouse neutrophils.
Endo D, Saito T, Umeki Y, Suzuki K, Aratani Y. | 10/22/2016 |
| Myeloperoxidase may be an important determinant of diet and inflammation on colon cancer risk via its effect on endogenous exposure to oxidants and acrolein. | Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice.
Al-Salihi M, Reichert E, Fitzpatrick FA., Free PMC Article | 09/3/2016 |
| Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity. | Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity.
Levine AP, Duchen MR, de Villiers S, Rich PR, Segal AW., Free PMC Article | 06/4/2016 |
| ethanol catabolism in renal tubules results in a self-perpetuating cycle of CYP2E1 induction, local PTAFR ligand formation, and neutrophil infiltration and activation that leads to myeloperoxidase-dependent oxidation and damage to kidney function. | Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption.
Latchoumycandane C, Nagy LE, McIntyre TM., Free PMC Article | 06/4/2016 |