| N-glycosylation of mannose receptor (CD206) regulates glycan binding by C-type lectin domains. | N-glycosylation of mannose receptor (CD206) regulates glycan binding by C-type lectin domains.
Stavenhagen K, Mehta AY, Laan L, Gao C, Heimburg-Molinaro J, van Die I, Cummings RD., Free PMC Article | 01/14/2023 |
| The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with (99m)Tc-Tilmanocept SPECT. | The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with (99m)Tc-Tilmanocept SPECT.
Bouchard A, Sikner H, Baverel V, Garnier AR, Monterrat M, Moreau M, Limagne E, Garrido C, Kohli E, Collin B, Bellaye PS., Free PMC Article | 01/22/2022 |
| Reduced TGF-beta Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice. | Reduced TGF-β Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice.
Yokozeki Y, Kawakubo A, Miyagi M, Kuroda A, Sekiguchi H, Inoue G, Takaso M, Uchida K., Free PMC Article | 09/25/2021 |
| CD206+ M2-Like Macrophages Are Essential for Successful Implantation. | CD206+ M2-Like Macrophages Are Essential for Successful Implantation.
Ono Y, Yoshino O, Hiraoka T, Sato E, Fukui Y, Ushijima A, Nawaz A, Hirota Y, Wada S, Tobe K, Nakashima A, Osuga Y, Saito S., Free PMC Article | 05/15/2021 |
| These studies support a critical but previously unrecognized role of MRC1 and miR-511-3p in protection against allergen-induced lung inflammation. | Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.
Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK, Gao P., Free PMC Article | 07/20/2019 |
| reduced bacterial loads occur in the airways of MRC-1-deficient mice and in mice in which MRC-1 is inhibited using blocking antibodies. | Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.
Subramanian K, Neill DR, Malak HA, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren PÅ, Plant L, Kadioglu A, Henriques-Normark B., Free PMC Article | 06/22/2019 |
| These results show that MR protects against a pathogenic inflammatory macrophage response induced by mannan and is associated with induction of ROS. | The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models.
Hagert C, Sareila O, Kelkka T, Jalkanen S, Holmdahl R., Free PMC Article | 03/9/2019 |
| findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium | Mycobacterium lepraemurium uses TLR-6 and MR, but not lipid rafts or DC-sign, to gain access into mouse macrophages.
Silva-Miranda M, Arce-Paredes P, Rojas-Espinosa O. | 07/14/2018 |
| current study shows that Mrc1-/- mice develop less severe dextran sulfate sodium-induced colitis | miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation.
Heinsbroek SE, Squadrito ML, Schilderink R, Hilbers FW, Verseijden C, Hofmann M, Helmke A, Boon L, Wildenberg ME, Roelofs JJ, Ponsioen CY, Peters CP, Te Velde AA, Gordon S, De Palma M, de Jonge WJ. | 11/4/2017 |
| the key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation. | Functional Consequences of Mannose and Asialoglycoprotein Receptor Ablation.
Mi Y, Coonce M, Fiete D, Steirer L, Dveksler G, Townsend RR, Baenziger JU., Free PMC Article | 05/20/2017 |
| PLA2 may prevent inflammatory responses in cisplatin-induced acute kidney injury by modulating Treg cells and IL-10 through the CD206 mannose receptor. | Phospholipase A2 inhibits cisplatin-induced acute kidney injury by modulating regulatory T cells by the CD206 mannose receptor.
Kim H, Lee H, Lee G, Jang H, Kim SS, Yoon H, Kang GH, Hwang DS, Kim SK, Chung HS, Bae H. | 06/11/2016 |
| Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection. | Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection.
Dai K, Huang L, Sun X, Yang L, Gong Z. | 03/26/2016 |
| CD206-positive pulmonary macrophages have a critical role in triggering inflammatory cascade during endotoxemic lung inflammation | In vivo depletion of CD206+ M2 macrophages exaggerates lung injury in endotoxemic mice.
Kambara K, Ohashi W, Tomita K, Takashina M, Fujisaka S, Hayashi R, Mori H, Tobe K, Hattori Y. | 09/26/2015 |
| These findings suggest that MR plays a major role in Enterococcus faecalis strain EC-12 phagocytosis by the antigen-presenting cells. | Role of the mannose receptor in phagocytosis of Enterococcus faecalis strain EC-12 by antigen-presenting cells.
Tsuruta T, Inoue R, Nagino T, Nishibayashi R, Makioka Y, Ushida K., Free PMC Article | 04/5/2014 |
| Syk was involved in the CLR-mediated activation of mast cells by BP | Mannose receptor and macrophage galactose-type lectin are involved in Bordetella pertussis mast cell interaction.
Vukman KV, Ravidà A, Aldridge AM, O'Neill SM. | 11/16/2013 |
| Genetic ablation of the Mrc1 impaired the intracellular collagen degradation pathway. | M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.
Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH., Free PMC Article | 11/16/2013 |
| Report CD44/macrophage mannose receptor as a ligand/receptor pair involved in the process of lymphocyte transit via the lymphatic vasculature. | CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics.
Salmi M, Karikoski M, Elima K, Rantakari P, Jalkanen S. | 08/31/2013 |
| study reports the macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors signature composed of Dectin-1, mannose receptor (MR)and the DC-SIGN homolog SIGNR3 expression | The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.
Lefèvre L, Lugo-Villarino G, Meunier E, Valentin A, Olagnier D, Authier H, Duval C, Dardenne C, Bernad J, Lemesre JL, Auwerx J, Neyrolles O, Pipy B, Coste A. | 08/3/2013 |
| These findings suggest that MRC1 plays an important role in the uptake of various bacteria by trophoblast giant cells and may provide an opportunity for those bacteria to escape from phagosomes. | Mannose receptor, C type 1 contributes to bacterial uptake by placental trophoblast giant cells.
Hashino M, Tachibana M, Shimizu T, Watarai M. | 06/15/2013 |
| The results suggest that MRC1 plays a critical role in myeloid plasticity, which in turn affects the adaptive immune response and immunopathogenesis during murine neurocysticercosis. | Increased accumulation of regulatory granulocytic myeloid cells in mannose receptor C type 1-deficient mice correlates with protection in a mouse model of neurocysticercosis.
Mishra PK, Morris EG, Garcia JA, Cardona AE, Teale JM., Free PMC Article | 05/18/2013 |
| CD206 is an pattern recognition receptor in detection of the infective Schistosoma mansoni and modulates IFNgamma production. | The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production.
Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L, Mountford AP. | 03/24/2012 |
| Data show that MR polyubiquitination mediates the recruitment of p97 toward the endosomal membrane, proving the central role of the endocytic receptor and its ubiquitination in antigen translocation. | Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation.
Zehner M, Chasan AI, Schuette V, Embgenbroich M, Quast T, Kolanus W, Burgdorf S., Free PMC Article | 10/1/2011 |
| The mannose receptor (MR) is the primary receptor mediating the internalization of environmental allergen glycoproteins by dendritic cells. Signals originating from the MR and TLR-2 receptors converge with the notch 1 signalling pathway. | The dendritic cell mannose receptor mediates allergen internalization and maturation involving notch 1 signalling.
Li J, Jiang H, Wen W, Zheng J, Xu G., Free PMC Article | 01/15/2011 |
| The authors conclude that lectin-mediated interactions of influenza virus with the MMR or the MGL are required for the endocytic uptake of the virus into macrophages. | Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry.
Upham JP, Pickett D, Irimura T, Anders EM, Reading PC., Free PMC Article | 04/12/2010 |
| This study provides a profile of MR N-linked glycosylation that will facilitate our understanding of their physiological role on MR biology in vivo. | Detailed N-glycan analysis of mannose receptor purified from murine spleen indicates tissue specific sialylation.
Su Y, Royle L, Radcliffe CM, Harvey DJ, Dwek RA, Martinez-Pomares L, Rudd PM. | 01/21/2010 |