| Elevated mitochondrial DNA copy number found in ubiquinone-deficient clk-1 mutants is not rescued by ubiquinone precursor 2-4-dihydroxybenzoate. | Elevated mitochondrial DNA copy number found in ubiquinone-deficient clk-1 mutants is not rescued by ubiquinone precursor 2-4-dihydroxybenzoate.
Kirby CS, Patel MR., Free PMC Article | 01/15/2022 |
| Loss of ubiquinone biosynthesis is responsible for all phenotypes resulting from loss of CLK-1, including behavioral phenotypes, altered expression of mitochondrial quality control genes, and lifespan. | A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1.
Liu JL, Yee C, Wang Y, Hekimi S., Free PMC Article | 09/8/2018 |
| Nuclear CLK-1 mediates a retrograde signalling pathway that is conserved from Caenorhabditis elegans to humans and is responsive to mitochondrial reactive oxygen species, thus acting as a barometer of oxidative metabolism. | A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
Monaghan RM, Barnes RG, Fisher K, Andreou T, Rooney N, Poulin GB, Whitmarsh AJ., Free PMC Article | 09/5/2015 |
| no measurable intrinsic ETC defect exists in clk-1 mitochondria. The data indicate that DMQ(9) specifically inhibits electron transfer from complex I to ubiquinone. | The role of DMQ(9) in the long-lived mutant clk-1.
Yang YY, Vasta V, Hahn S, Gangoiti JA, Opheim E, Sedensky MM, Morgan PG., Free PMC Article | 12/10/2011 |
| action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1. | The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
Wang Y, Branicky R, Stepanyan Z, Carroll M, Guimond MP, Hihi A, Hayes S, McBride K, Hekimi S. | 01/21/2010 |
| in maternally resqued animals, the effect of clk-1 mutations on adult lifespan in uncoupled from their effects on development and reproduction | Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans.
Burgess J, Hihi AK, Benard CY, Branicky R, Hekimi S. | 01/21/2010 |
| Caenorhabditis elegans clk-1 mutants are sensitive to ubiquinone side-chain length | Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.
Hihi AK, Kebir H, Hekimi S. | 01/21/2010 |
| Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1. | Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1, a product of the longevity gene of the nematode worm.
Adachi A, Shinjyo N, Fujita D, Miyoshi H, Amino H, Watanabe Yi, Kita K. | 01/21/2010 |
| Suppressors of the missense mutation of clk-1 were identified; each mutant suppresses a different subset of phenotypes. | Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.
Branicky R, Nguyen PA, Hekimi S., Free PMC Article | 01/21/2010 |
| Prolonged life span of Clk mutants cannot be attributed to reduced metabolic rate or an increased activity of the major antioxidant enzymes catalase and SOD. | No reduction of energy metabolism in Clk mutants.
Braeckman BP, Houthoofd K, Brys K, Lenaerts I, De Vreese A, Van Eygen S, Raes H, Vanfleteren JR. | 01/21/2010 |
| differential fertility of clk-1 mutant nematodes fed Q isoforms may result from changes in Q localization, altered recognition by Q-binding proteins, and/or potential defects in mitochondrial function resulting from the mutant CLK-1 polypeptide itself. | Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length.
Jonassen T, Davis DE, Larsen PL, Clarke CF. | 01/21/2010 |