| Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2). | Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2).
Ortega-Gascó A, Parcerisas A, Hino K, Herranz-Pérez V, Ulloa F, Elias-Tersa A, Bosch M, García-Verdugo JM, Simó S, Pujadas L, Soriano E., Free PMC Article | 11/14/2023 |
| Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits. | Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits.
Sah S, Keable R, Pfundstein G, Clemens KJ, Begg D, Schachner M, Leshchyns'ka I, Sytnyk V. | 09/19/2023 |
| The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes. | The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes.
Keable R, Hu S, Pfundstein G, Kozlova I, Su F, Du X, Yang H, Gunnersen J, Schachner M, Leshchyns'ka I, Sytnyk V., Free PMC Article | 10/22/2022 |
| NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3. | NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
Parcerisas A, Pujadas L, Ortega-Gascó A, Perelló-Amorós B, Viais R, Hino K, Figueiro-Silva J, La Torre A, Trullás R, Simó S, Lüders J, Soriano E., Free PMC Article | 12/25/2021 |
| New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization. | New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization.
Parcerisas A, Ortega-Gascó A, Hernaiz-Llorens M, Odena MA, Ulloa F, de Oliveira E, Bosch M, Pujadas L, Soriano E., Free PMC Article | 08/14/2021 |
| Study demonstrates that an increase in NCAM2 levels results in increased instability of dendritic protrusions and reduced conversion of protrusions to dendritic spines in mouse cortical neurons. | Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation.
Sheng L, Leshchyns'ka I, Sytnyk V. | 05/23/2020 |
| Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss. | Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.
Leshchyns'ka I, Liew HT, Shepherd C, Halliday GM, Stevens CH, Ke YD, Ittner LM, Sytnyk V., Free PMC Article | 05/28/2016 |
| These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling | OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor.
Deleyrolle L, Sabourin JC, Rothhut B, Fujita H, Guichet PO, Teigell M, Ripoll C, Chauvet N, Perrin F, Mamaeva D, Noda T, Mori K, Yoshihara Y, Hugnot JP., Free PMC Article | 01/16/2016 |
| This study identified the cell adhesion molecule NCAM2 as a new regulator of filopodial formation and neurite branching. | Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels.
Sheng L, Leshchyns'ka I, Sytnyk V., Free PMC Article | 04/11/2015 |
| Two novel Mmatrix metallopeptidase 9 targets were identified: synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 | Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome.
Bajor M, Michaluk P, Gulyassy P, Kekesi AK, Juhasz G, Kaczmarek L. | 09/29/2012 |
| Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli. | Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli.
Borisovska M, McGinley MJ, Bensen A, Westbrook GL., Free PMC Article | 08/13/2011 |
| OCAM is required for establishing or maintaining the compartmental organization and the segregation of axodendritic and dendrodendritic synapses within glomeruli. | Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAM.
Walz A, Mombaerts P, Greer CA, Treloar HB. | 01/21/2010 |
| Data suggest that two distinct RNCAM isoform-dependent activities influence segregation of odorant receptor-defined axon subclasses. | Differential function of RNCAM isoforms in precise target selection of olfactory sensory neurons.
Alenius M, Bohm S. | 01/21/2010 |