| The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function. | The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function.
Park J, Cho Y, Yang D, Yang H, Lee D, Kubo M, Kang SJ. | 01/26/2024 |
| CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4. | CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Lin L, Huang Y, Wang J, Guo X, Yu F, He D, Wu C, Guo L, Wu B. | 12/5/2023 |
| High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice. | High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice.
Wang S, Yang M, Li P, Sit J, Wong A, Rodrigues K, Lank D, Zhang D, Zhang K, Yin L, Tong X., Free PMC Article | 02/28/2023 |
| NFIL3 deficiency alleviates EAE through regulating different immune cell subsets. | NFIL3 deficiency alleviates EAE through regulating different immune cell subsets.
Chen Z, Fan R, Liang J, Xiao Z, Dang J, Zhao J, Weng R, Zhu C, Zheng SG, Jiang Y., Free PMC Article | 07/16/2022 |
| E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice. | E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice.
Wang Z, Gao L, Ren S, Sun G, Lin Y, Wang S, Wu B. | 05/7/2022 |
| Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress. | Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress.
Yang M, Zhang D, Zhao Z, Sit J, Saint-Sume M, Shabandri O, Zhang K, Yin L, Tong X., Free PMC Article | 04/24/2021 |
| E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases. | E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
Wang Z, Zhao M, Yin J, Liu L, Hu L, Huang Y, Liu A, Ouyang J, Min X, Rao S, Zhou W, Wu H, Yoshimura A, Lu Q., Free PMC Article | 02/6/2021 |
| The ILC3s are attuned to circadian rhythm, but clock regulator REV-ERBalpha also has circadian-independent impacts on ILC3 development and functions due to its roles in the regulation of RORgammat. | Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells.
Wang Q, Robinette ML, Billon C, Collins PL, Bando JK, Fachi JL, Sécca C, Porter SI, Saini A, Gilfillan S, Solt LA, Musiek ES, Oltz EM, Burris TP, Colonna M., Free PMC Article | 08/1/2020 |
| The data indicate that NFIL3 impairs Regulatory T (Treg) cell function through the downregulation of Foxp3 expression. | The transcription factor NFIL3 controls regulatory T-cell function and stability.
Kim HS, Sohn H, Jang SW, Lee GR., Free PMC Article | 06/27/2020 |
| D-box-mediated transcriptional regulation plays pivotal roles in input and output in the circadian clock system. | Functional D-box sequences reset the circadian clock and drive mRNA rhythms.
Yoshitane H, Asano Y, Sagami A, Sakai S, Suzuki Y, Okamura H, Iwasaki W, Ozaki H, Fukada Y., Free PMC Article | 04/25/2020 |
| Our results indicate that the action of E4bp4 in NK cells is highly regulated and can potentially be strongly influenced by extrinsic stimuli | Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Kostrzewski T, Borg AJ, Meng Y, Filipovic I, Male V, Wack A, DiMaggio PA, Brady HJM., Free PMC Article | 03/2/2019 |
| Data indicate E4BP4/NFIL3 as a direct Smad3 target gene critical for NK cell differentiation. | Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development.
Tang PM, Zhou S, Meng XM, Wang QM, Li CJ, Lian GY, Huang XR, Tang YJ, Guan XY, Yan BP, To KF, Lan HY., Free PMC Article | 12/22/2018 |
| These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism. | The intestinal microbiota regulates body composition through NFIL3 and the circadian clock.
Wang Y, Kuang Z, Yu X, Ruhn KA, Kubo M, Hooper LV., Free PMC Article | 03/3/2018 |
| E4BP4 acts as a key pro-adipogenic transcription factor by trans-repressing COX2 in glucocorticoid-associated adipocyte differentiation. | E4BP4 mediates glucocorticoid-regulated adipogenesis through COX2.
Yang Y, Wei H, Song T, Cai A, Zhou Y, Peng J, Jiang S, Peng J. | 02/24/2018 |
| NFIL3 functions as an important regulator of glucose homeostasis in the liver by limiting CREB-mediated hepatic gluconeogenesis. | NFIL3 is a negative regulator of hepatic gluconeogenesis.
Kang G, Han HS, Koo SH. | 12/2/2017 |
| We identified PD-1 to be specifically expressed in PLZF(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3, ID2, and TCF-1 was critical. Importantly, induction of ILC lineage commitment required only transient expression of NFIL3 prior to ID2 and TCF-1 expression. | Deciphering the Innate Lymphoid Cell Transcriptional Program.
Seillet C, Mielke LA, Amann-Zalcenstein DB, Su S, Gao J, Almeida FF, Shi W, Ritchie ME, Naik SH, Huntington ND, Carotta S, Belz GT. | 12/2/2017 |
| Uterine lumen closure, early embryonic development, and differentiation of antimesometrial decidua were delayed in Nfil3(-/-) implantation sites. Major disturbances to the decidual-trophoblast interface that did not lead to fetal death were attributed to NFIL3 deficiency in trophoblast. | The Transcription Factor NFIL3 Is Essential for Normal Placental and Embryonic Development but Not for Uterine Natural Killer (UNK) Cell Differentiation in Mice.
Redhead ML, Portilho NA, Felker AM, Mohammad S, Mara DL, Croy BA. | 11/4/2017 |
| In hepatocytes, E4BP4 interacts with nuclear SREBP-1c to preserve its acetylation, and subsequently protects it from ubiquitination-dependent degradation | E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.
Tong X, Li P, Zhang D, VanDommelen K, Gupta N, Rui L, Omary MB, Yin L., Free PMC Article | 08/26/2017 |
| study found that approximately one quarter of the submandibular salivary gland (SMG) NK cells develop independently of NFIL3; data show that the SMG tissue environment shapes a unique repertoire of NK-like cells with distinct phenotypes | NFIL3 Expression Distinguishes Tissue-Resident NK Cells and Conventional NK-like Cells in the Mouse Submandibular Glands.
Erick TK, Anderson CK, Reilly EC, Wands JR, Brossay L., Free PMC Article | 08/19/2017 |
| New direct Wnt/beta-catenin target gene Nfil3 , which induced epithelial-mesenchymal transition, cell migration and experimental metastasis of Colorectal cancer cells was identified. | New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
Qi J, Yu Y, Akilli Öztürk Ö, Holland JD, Besser D, Fritzmann J, Wulf-Goldenberg A, Eckert K, Fichtner I, Birchmeier W. | 06/24/2017 |
| removal of NFIL3 in vivo does not recapitulate the regeneration-promoting effects that were previously observed in vitro. | Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo.
van der Kallen LR, Eggers R, Ehlert EM, Verhaagen J, Smit AB, van Kesteren RE., Free PMC Article | 04/23/2016 |
| These findings establish that NFIL3 directs the differentiation of a committed innate lymphoid cell precursor. | The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor.
Yu X, Wang Y, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV., Free PMC Article | 04/16/2016 |
| These data identify an IL-27/NFIL3 signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 and T-cell dysfunction. | An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK., Free PMC Article | 02/6/2016 |
| establish NFIL3 as a key regulator of common helper-like innate lymphoid cells progenitors as they emerge during early lymphopoiesis | NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors.
Xu W, Domingues RG, Fonseca-Pereira D, Ferreira M, Ribeiro H, Lopez-Lastra S, Motomura Y, Moreira-Santos L, Bihl F, Braud V, Kee B, Brady H, Coles MC, Vosshenrich C, Kubo M, Di Santo JP, Veiga-Fernandes H. | 01/23/2016 |
| Iso-mediated induction of Nfil3 in osteoblasts regulates the expression of Ptgs2 by driving the expression of circadian clock genes | β-adrenergic receptor signaling regulates Ptgs2 by driving circadian gene expression in osteoblasts.
Hirai T, Tanaka K, Togari A. | 08/15/2015 |