| Structural basis of NINJ1-mediated plasma membrane rupture in cell death. | Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
Degen M, Santos JC, Pluhackova K, Cebrero G, Ramos S, Jankevicius G, Hartenian E, Guillerm U, Mari SA, Kohl B, Müller DJ, Schanda P, Maier T, Perez C, Sieben C, Broz P, Hiller S., Free PMC Article | 07/6/2023 |
| The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration. | The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration.
Hu Y, Zhan F, Wang Y, Wang D, Lu H, Wu C, Xia Y, Meng L, Zhang F, Wang X, Zhou S., Free PMC Article | 04/24/2023 |
| NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation. | NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation.
Zhou X, Yu X, Wan C, Li F, Wang Y, Zhang K, Feng L, Wen A, Deng J, Li S, Xin G, Huang W., Free PMC Article | 02/28/2023 |
| Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death. | Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Borges JP, Sætra RSR, Volchuk A, Bugge M, Devant P, Sporsheim B, Kilburn BR, Evavold CL, Kagan JC, Goldenberg NM, Flo TH, Steinberg BE., Free PMC Article | 01/14/2023 |
| Deficiency of Ninjurin1 attenuates LPS/D-galactosamine-induced acute liver failure by reducing TNF-alpha-induced apoptosis in hepatocytes. | Deficiency of Ninjurin1 attenuates LPS/D-galactosamine-induced acute liver failure by reducing TNF-α-induced apoptosis in hepatocytes.
Kim MW, Kang JH, Jung HJ, Park SY, Hwang JI, Seong JK, Yoon YS, Oh SH., Free PMC Article | 10/22/2022 |
| miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1. | miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1.
Hwang SJ, Ahn BJ, Shin MW, Song YS, Choi Y, Oh GT, Kim KW, Lee HJ., Free PMC Article | 06/18/2022 |
| Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis. | Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis.
Jeon S, Kim TK, Jeong SJ, Jung IH, Kim N, Lee MN, Sonn SK, Seo S, Jin J, Kweon HY, Kim S, Shim D, Park YM, Lee SH, Kim KW, Cybulsky MI, Shim H, Roh TY, Park WY, Lee HO, Choi JH, Park SH, Oh GT. | 10/2/2021 |
| Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature. | Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature.
Horiuchi K, Kano K, Minoshima A, Hayasaka T, Yamauchi A, Tatsukawa T, Matsuo R, Yoshida Y, Tomita Y, Kabara M, Nakagawa N, Takehara N, Hasebe N, Kawabe JI. | 07/24/2021 |
| NINJ1 mediates plasma membrane rupture during lytic cell death. | NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM. | 07/24/2021 |
| Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions. | Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions.
Jung HJ, Kang JH, Pak S, Lee K, Seong JK, Oh SH., Free PMC Article | 10/24/2020 |
| Data indicate that ninjurin 1 (Ninj1) plays a vital role in peripheral nerve regeneration observed particularly in the myelination process of nerve/glial antigen 2 (NG2(+)) cells. | Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells.
Tomita Y, Horiuchi K, Kano K, Tatsukawa T, Matsuo R, Hayasaka T, Yoshida Y, Kabara M, Yasuda S, Nakajima K, Nakagawa N, Takehara N, Okizaki A, Hasebe N, Kawabe JI. | 06/27/2020 |
| Ninjurin1 was increased in hearts of aortic stenosis patients, compared to controls, as well as in hearts from mice with cardiac hypertrophy | Ninjurin1 regulates striated muscle growth and differentiation.
Kny M, Csályi KD, Klaeske K, Busch K, Meyer AM, Merks AM, Darm K, Dworatzek E, Fliegner D, Baczko I, Regitz-Zagrosek V, Butter C, Luft FC, Panáková D, Fielitz J., Free PMC Article | 01/25/2020 |
| Ninj1 may be involved in the development of pulmonary fibrosis by enhancing inflammatory response of macrophages. | Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells.
Choi S, Woo JK, Jang YS, Kang JH, Hwang JI, Seong JK, Yoon YS, Oh SH., Free PMC Article | 10/26/2019 |
| Ninj1 is involved in the formation of functional matured vessels through the association between pericytes and endothelial cells, resulting in blood flow recovery from ischemia. | Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia.
Minoshima A, Kabara M, Matsuki M, Yoshida Y, Kano K, Tomita Y, Hayasaka T, Horiuchi K, Saito Y, Aonuma T, Nishimura M, Maruyama K, Nakagawa N, Sawada J, Takehara N, Hasebe N, Kawabe JI., Free PMC Article | 08/10/2019 |
| Ninj1 expression is dynamically regulated during osteoclastogenesis. Ninj1-/- mice exhibit increased trabecular bone volume. | Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts.
Bae SJ, Shin MW, Son T, Lee HS, Chae JS, Jeon S, Oh GT, Kim KW., Free PMC Article | 06/15/2019 |
| Ninj1 knock-out mice exhibit compulsive grooming behavior and increased anxiety-like behavior. | Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice.
Le H, Ahn BJ, Lee HS, Shin A, Chae S, Lee SY, Shin MW, Lee EJ, Cha JH, Son T, Seo JH, Wee HJ, Lee HJ, Jang Y, Lo EH, Jeon S, Oh GT, Kim D, Kim KW. | 05/11/2019 |
| Ninjurin1 is a key regulator molecule for macrophage migration and Tumor-associated macrophages (TAM) mediated tumorigenesis in vivo. | Ninjurin1 inhibits colitis-mediated colon cancer development and growth by suppression of macrophage infiltration through repression of FAK signaling.
Woo JK, Jang YS, Kang JH, Hwang JI, Seong JK, Lee SJ, Jeon S, Oh GT, Lee HY, Oh SH., Free PMC Article | 01/13/2018 |
| Data show that Ninj1 assembles into a homomeric protein complex and that N-glycosylation is a prerequisite for Ninj1 homomer assembly. | Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation.
Bae SJ, Shin MW, Kim RH, Shin D, Son T, Wee HJ, Kim KW. | 12/30/2017 |
| Ninj1 negatively regulates the formation of neovessels, that is, the EC-tube, by reducing the trophic effects of capillary pericytes. | Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes.
Matsuki M, Kabara M, Saito Y, Shimamura K, Minoshima A, Nishimura M, Aonuma T, Takehara N, Hasebe N, Kawabe J. | 03/5/2016 |
| Ninj1 modulates TLR4 signaling, which itself plays a major role in systemic inflammatory response syndrome and sepsis. | Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation.
Jennewein C, Sowa R, Faber AC, Dildey M, von Knethen A, Meybohm P, Scheller B, Dröse S, Zacharowski K. | 02/6/2016 |
| Ninjurin1-deficient bone marrow-derived macrophages exhibited reduced membrane protrusion formation and dynamics, resulting in the impairment of cell motility. | Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics.
Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Lee SY, Yang JH, Wee HJ, Cha JH, Seo JH, Lee HS, Lee HJ, Arai K, Lo EH, Jeon S, Oh GT, Kim WJ, Ryu JK, Suh JK, Kim KW., Free PMC Article | 02/21/2015 |
| Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse. | Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse.
Yin GN, Choi MJ, Kim WJ, Kwon MH, Song KM, Park JM, Das ND, Kwon KD, Batbold D, Oh GT, Koh GY, Kim KW, Ryu JK, Suh JK., Free PMC Article | 09/27/2014 |
| The dual neurotrophic and angiogenic effects of Ninj1 blockade may provide a good opportunity for treating erectile dysfunction resulting from radical prostatectomy. | Nerve injury-induced protein 1 (Ninjurin-1) is a novel therapeutic target for cavernous nerve injury-induced erectile dysfunction in mice.
Yin GN, Kim WJ, Jin HR, Kwon MH, Song KM, Choi MJ, Park JM, Das ND, Kwon KD, Batbold D, Kim KW, Ryu JK, Suh JK. | 06/28/2014 |
| Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice | Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice.
Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Lee HJ, Lee HS, Kim JH, Kim CY, Seo JH, Lo EH, Jeon S, Lee MN, Oh GT, Yin GN, Ryu JK, Suh JK, Kim KW., Free PMC Article | 04/12/2014 |
| Ninj1 plays a role in p53-mediated tumor suppression in addition to nerve regeneration. | Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality.
Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, Chen X., Free PMC Article | 08/10/2013 |