| NR4a1/2 deletion promotes accumulation of TCF1[+] stem-like precursors of exhausted CD8[+] T cells in the tumor microenvironment. | NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment.
Srirat T, Hayakawa T, Mise-Omata S, Nakagawara K, Ando M, Shichino S, Ito M, Yoshimura A. | 04/3/2024 |
| Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex. | Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex.
He Y, Wang Y, Yu H, Tian Y, Chen X, Chen C, Ren Y, Chen Z, Ren Y, Gong X, Cheng K, Liu X, Zhong L, Guo Y, Xie P. | 05/13/2023 |
| Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. | Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation.
Pulcrano S, De Gregorio R, De Sanctis C, Lahti L, Perrone-Capano C, Ponti D, di Porzio U, Perlmann T, Caiazzo M, Volpicelli F, Bellenchi GC., Free PMC Article | 07/23/2022 |
| Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice. | Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice.
Ashraf S, Taegtmeyer H, Harmancey R., Free PMC Article | 07/16/2022 |
| Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons. | Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons.
Abdollahi M, Fahnestock M., Free PMC Article | 07/2/2022 |
| Nurr1 repression mediates cardinal features of Parkinson's disease in alpha-synuclein transgenic mice. | Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice.
Argyrofthalmidou M, Spathis AD, Maniati M, Poula A, Katsianou MA, Sotiriou E, Manousaki M, Perier C, Papapanagiotou I, Papadopoulou-Daifoti Z, Pitychoutis PM, Alexakos P, Vila M, Stefanis L, Vassilatis DK., Free PMC Article | 04/16/2022 |
| Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype. | Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.
Partington HS, Nutter JM, Eells JB. | 02/12/2022 |
| Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development. | Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development.
Wang Y, Li C, Zhang Y, Zha X, Zhang H, Hu Z, Wu C. | 01/8/2022 |
| Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model. | Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model.
Xu X, He X, Ma S, Li M, Huang Q. | 01/8/2022 |
| Nurr1(Cd11bcre) conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons. | Nurr1(Cd11bcre) conditional knockout mice display inflammatory injury to nigrostriatal dopaminergic neurons.
Dong J, Liu X, Wang Y, Cai H, Le W., Free PMC Article | 11/13/2021 |
| Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-kappaB pathway. | Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-κB pathway.
Hu L, Si L, Dai X, Dong H, Ma Z, Sun Z, Li N, Sha H, Chen Y, Qian Y, Zhang Z., Free PMC Article | 11/13/2021 |
| The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice. | The transcription factor Nurr1 is upregulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice.
Valsecchi V, Boido M, Montarolo F, Guglielmotto M, Perga S, Martire S, Cutrupi S, Iannello A, Gionchiglia N, Signorino E, Calvo A, Fuda G, Chiò A, Bertolotto A, Vercelli A., Free PMC Article | 06/12/2021 |
| Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation. | Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation.
Oh M, Kim SY, Gil JE, Byun JS, Cha DW, Ku B, Lee W, Kim WK, Oh KJ, Lee EW, Bae KH, Lee SC, Han BS., Free PMC Article | 01/9/2021 |
| The Transcription Factor NR4A2 Plays an Essential Role in Driving Prolactin Expression in Female Pituitary Lactotropes. | The Transcription Factor NR4A2 Plays an Essential Role in Driving Prolactin Expression in Female Pituitary Lactotropes.
Peel MT, Ho Y, Liebhaber SA., Free PMC Article | 01/9/2021 |
| Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases. | Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.
Park TY, Jang Y, Kim W, Shin J, Toh HT, Kim CH, Yoon HS, Leblanc P, Kim KS., Free PMC Article | 11/21/2020 |
| elevated levels of nuclear receptor subfamily 4 group A member 2 (Nurr1) are associated with the pro-inflammatory profile of alpha-synuclein-deficient CD4(+) T cells | Alpha synuclein deficiency increases CD4(+) T-cells pro-inflammatory profile in a Nurr1-dependent manner.
Trudler D, Levy-Barazany H, Nash Y, Samuel L, Sharon R, Frenkel D. | 07/4/2020 |
| Acute stress suppresses but chronic stress conversely induces Nr4a2 expression in hippocampal dentate gyrus granule cells (GCs). The survival of newly generated GCs is impaired by chronic restraint stress, and long-term stress after middle age decreases the proportion of late-born GCs in aged mice. | Differential expression of a stress-regulated gene Nr4a2 characterizes early- and late-born hippocampal granule cells.
Imura T, Kobayashi Y, Suzutani K, Ichikawa-Tomikawa N, Chiba H. | 06/6/2020 |
| Nurr1 critically regulates Alzheimer's disease-related pathophysiology. | Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model.
Moon M, Jung ES, Jeon SG, Cha MY, Jang Y, Kim W, Lopes C, Mook-Jung I, Kim KS., Free PMC Article | 04/4/2020 |
| Identify NURR1 agonists as possible exercise mimetics with the potential to ameliorate obesity and other metabolic abnormalities. | NURR1 activation in skeletal muscle controls systemic energy homeostasis.
Amoasii L, Sanchez-Ortiz E, Fujikawa T, Elmquist JK, Bassel-Duby R, Olson EN., Free PMC Article | 03/28/2020 |
| Our study suggests that the NURR1 deficient male mouse may be a satisfactory model to study some ADHD behavioral phenotypes and to test the clinical efficacy of potential therapeutic agents. | NURR1 deficiency is associated to ADHD-like phenotypes in mice.
Montarolo F, Martire S, Perga S, Spadaro M, Brescia I, Allegra S, De Francia S, Bertolotto A., Free PMC Article | 03/14/2020 |
| PPARalpha is a novel regulator of Nurr1 expression and associated protection of dopaminergic neurons. | Activation of Peroxisome Proliferator-Activated Receptor-α Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons.
Gottschalk CG, Roy A, Jana M, Kundu M, Pahan K., Free PMC Article | 03/14/2020 |
| Regulation of NR4A2 function in the medial habenula is critical in relapse-like behaviors. | Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior.
López AJ, Hemstedt TJ, Jia Y, Hwang PH, Campbell RR, Kwapis JL, White AO, Chitnis O, Scarfone VM, Matheos DP, Lynch G, Wood MA., Free PMC Article | 03/7/2020 |
| Nurr1 regulated intestinal epithelial development and barrier function after intestinal ischemia/reperfusion injury. | miR-381-3p knockdown improves intestinal epithelial proliferation and barrier function after intestinal ischemia/reperfusion injury by targeting nurr1.
Liu L, Yao J, Li Z, Zu G, Feng D, Li Y, Qasim W, Zhang S, Li T, Zeng H, Tian X., Free PMC Article | 11/16/2019 |
| the pathogenesis of cerebral ischemia-reperfusion injury is associated with Nurr1 upregulation followed by augmented mitochondrial fission via an abnormal YAP-INF2 pathways | Nurr1 exacerbates cerebral ischemia-reperfusion injury via modulating YAP-INF2-mitochondrial fission pathways.
Zhang Z, Yu J. | 05/18/2019 |
| NR4A1/Nur77 and NR4A2/Nurr1 dynamically regulated inflammatory gene expression in glia by modulating the transcriptional activity of NF-kappaB. | Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB-Dependent Inflammatory Signaling in Astrocytes.
Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB., Free PMC Article | 04/20/2019 |