| PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway. | PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway.
Chen H, Li L, Liu H, Qin P, Chen R, Liu S, Xiong H, Li Y, Yang Z, Xie M, Yang H, Jiang Q. | 03/6/2024 |
| Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease. | Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.
Beamish JA, Telang AC, McElliott MC, Al-Suraimi A, Chowdhury M, Ference-Salo JT, Otto EA, Menon R, Soofi A, Weinberg JM, Patel SR, Dressler GR., | 02/2/2024 |
| Decreased Microglia in Pax2 Mutant Mice Leads to Impaired Learning and Memory. | Decreased Microglia in Pax2 Mutant Mice Leads to Impaired Learning and Memory.
Lv N, Wang Y, Liu Y, Tang J, Lei Q, Wang Y, Wei H. | 08/27/2022 |
| Cyclin-dependent kinase 4-related tubular epithelial cell proliferation is regulated by Paired box gene 2 in kidney ischemia-reperfusion injury. | Cyclin-dependent kinase 4-related tubular epithelial cell proliferation is regulated by Paired box gene 2 in kidney ischemia-reperfusion injury.
Sako K, Furuichi K, Makiishi S, Yamamura Y, Okumura T, Le HT, Kitajima S, Toyama T, Hara A, Iwata Y, Sakai N, Shimizu M, Niimura F, Matsusaka T, Kaneko S, Wada T. | 07/2/2022 |
| Increased repetitive self-grooming occurs in Pax2 mutant mice generated using CRISPR/Cas9. | Increased repetitive self-grooming occurs in Pax2 mutant mice generated using CRISPR/Cas9.
Wei H, Wang M, Lv N, Yang H, Zhao M, Huang B, Li R. | 10/30/2021 |
| Multiple roles for Pax2 in the embryonic mouse eye. | Multiple roles for Pax2 in the embryonic mouse eye.
Bosze B, Suarez-Navarro J, Soofi A, Lauderdale JD, Dressler GR, Brown NL., Free PMC Article | 06/26/2021 |
| Reduced PAX2 expression in murine fallopian tube cells enhances estrogen receptor signaling. | Reduced PAX2 expression in murine fallopian tube cells enhances estrogen receptor signaling.
Colina JA, Varughese P, Karthikeyan S, Salvi A, Modi DA, Burdette JE., Free PMC Article | 10/31/2020 |
| Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2. | Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2.
Lu M, Guo S, Hong F, Zhang Y, Yuan L, Ma C, Ma J. | 09/21/2019 |
| High fat diet-caused renal injury involved the inactivation of Pax2 and Ampk, and the activation of soluble epoxide hydrolase (sEH), in a murine model. | Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK.
Luo Y, Wu MY, Deng BQ, Huang J, Hwang SH, Li MY, Zhou CY, Zhang QY, Yu HB, Zhao DK, Zhang G, Qin L, Peng A, Hammock BD, Liu JY., Free PMC Article | 05/11/2019 |
| Pax2 (and Sox2) are both expressed in the prosensory cells, the developing hair cells of the vestibular and auditory sensory organs. | The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns.
Liu S, Wang Y, Lu Y, Li W, Liu W, Ma J, Sun F, Li M, Chen ZY, Su K, Li W., Free PMC Article | 01/12/2019 |
| Paired box protein Pax-2 (Pax2)EGFP expression indicates the location of hair cells at the organoid region. | From Otic Induction to Hair Cell Production: Pax2(EGFP) Cell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model.
Schaefer SA, Higashi AY, Loomis B, Schrepfer T, Wan G, Corfas G, Dressler GR, Duncan RK., Free PMC Article | 12/1/2018 |
| results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2-mediated neuronal differentiation in the inner ear | The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex.
Patel D, Shimomura A, Majumdar S, Holley MC, Hashino E., Free PMC Article | 03/17/2018 |
| Demonstrate the stepwise emergence of hitherto undescribed, differently Pax2/Pax8- coded anterior and posterior subdomains in the posterior placodal area of mice. | Pax2/Pax8-defined subdomains and the occurrence of apoptosis in the posterior placodal area of mice.
Washausen S, Knabe W. | 02/3/2018 |
| Mutant p53 and PTEN loss negatively regulated PAX2 and PAX2 re-expression in high-grade serous ovarian cancer cells induced cell death. | PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer.
Modi DA, Tagare RD, Karthikeyan S, Russo A, Dean M, Davis DA, Lantvit DD, Burdette JE., Free PMC Article | 09/23/2017 |
| Pax2 function maintains nephron progenitor cells by repressing a renal interstitial cell program. | Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A., Free PMC Article | 09/16/2017 |
| Pax2-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos. | Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice.
Chumak T, Bohuslavova R, Macova I, Dodd N, Buckiova D, Fritzsch B, Syka J, Pavlinkova G. | 12/31/2016 |
| PAX2 may not be a classical oncogene or tumor suppressor but instead can act in either role by differential regulation of COX2 and/or HTRA1. | Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer.
Al-Hujaily EM, Tang Y, Yao DS, Carmona E, Garson K, Vanderhyden BC. | 09/17/2016 |
| Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth. | Dicer function is required in the metanephric mesenchyme for early kidney development.
Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J., Free PMC Article | 09/22/2015 |
| Pax2 specifies the intermediate mesoderm and renal epithelial cells through epigenetic mechanisms and in part by repressing paraxial mesodermal fate. | Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms.
Ranghini EJ, Dressler GR., Free PMC Article | 05/9/2015 |
| Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1)-Pax2 protein knockout embryos. | Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.
Hou C, Ding L, Zhang J, Jin Y, Sun C, Li Z, Sun X, Zhang T, Zhang A, Li H, Gao J. | 12/20/2014 |
| a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization. | A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis.
Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M. | 12/14/2013 |
| the role of Pax2 protein levels in determining correct renal architecture and cell fate in urogenital development. | Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.
Soofi A, Levitan I, Dressler GR., Free PMC Article | 06/29/2013 |
| cross-talk between p53 and Pax2 provides a transcriptional platform that promotes nephrogenesis, thus contributing to nephron endowment | A p53-Pax2 pathway in kidney development: implications for nephrogenesis.
Saifudeen Z, Liu J, Dipp S, Yao X, Li Y, McLaughlin N, Aboudehen K, El-Dahr SS., Free PMC Article | 03/16/2013 |
| Hnf1b and Pax2 operate to control kidney morphogenesis and ureter differentiation. | Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis.
Paces-Fessy M, Fabre M, Lesaulnier C, Cereghini S. | 01/26/2013 |
| Hyperactivated Wnt signaling increased expression of the transcription factor Pax2 in the cells lining cysts in autosomal dominant polycystic kidney disease. | c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.
Qin S, Taglienti M, Cai L, Zhou J, Kreidberg JA., Free PMC Article | 10/20/2012 |