| Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development. | Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development.
Gruenbacher S, Jaritz M, Hill L, Schäfer M, Busslinger M., Free PMC Article | 09/22/2023 |
| Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets. | Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.
Bacos K, Perfilyev A, Karagiannopoulos A, Cowan E, Ofori JK, Bertonnier-Brouty L, Rönn T, Lindqvist A, Luan C, Ruhrmann S, Ngara M, Nilsson Å, Gheibi S, Lyons CL, Lagerstedt JO, Barghouth M, Esguerra JL, Volkov P, Fex M, Mulder H, Wierup N, Krus U, Artner I, Eliasson L, Prasad RB, Cataldo LR, Ling C., Free PMC Article | 02/23/2023 |
| PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-alpha Signaling Pathway. | PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-α Signaling Pathway.
Wang X, Guan Z, Tang W, Wang X, Xu C, Shan E, Wang W, Gao Y. | 02/18/2023 |
| The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa. | The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y., Free PMC Article | 09/24/2022 |
| The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation. | The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.
Jurado S, Fedl AS, Jaritz M, Kostanova-Poliakova D, Malin SG, Mullighan CG, Strehl S, Fischer M, Busslinger M., Free PMC Article | 04/9/2022 |
| Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation. | Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.
Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M., Free PMC Article | 03/12/2022 |
| Pax5 mediates the transcriptional activation of the CD81 gene. | Pax5 mediates the transcriptional activation of the CD81 gene.
Hosokawa K, Ishimaru H, Watanabe T, Fujimuro M., Free PMC Article | 02/5/2022 |
| EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene. | EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene.
Somasundaram R, Jensen CT, Tingvall-Gustafsson J, Åhsberg J, Okuyama K, Prasad M, Hagman JR, Wang X, Soneji S, Strid T, Ungerbäck J, Sigvardsson M., Free PMC Article | 12/4/2021 |
| B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors. | B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors.
Strid T, Okuyama K, Tingvall-Gustafsson J, Kuruvilla J, Jensen CT, Lang S, Prasad M, Somasundaram R, Åhsberg J, Cristobal S, Soneji S, Ungerbäck J, Sigvardsson M. | 10/2/2021 |
| Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1. | Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1.
Yu J, Kim S, Lee N, Jeon H, Lee J, Takami M, Rho J., Free PMC Article | 04/17/2021 |
| Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis. | Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis.
Isidro-Hernández M, Mayado A, Casado-García A, Martínez-Cano J, Palmi C, Fazio G, Orfao A, Ribera J, Ribera JM, Zamora L, Raboso-Gallego J, Blanco O, Alonso-López D, De Las Rivas J, Jiménez R, García Criado FJ, García Cenador MB, Ramírez-Orellana M, Cazzaniga G, Cobaleda C, Vicente-Dueñas C, Sánchez-García I., Free PMC Article | 03/13/2021 |
| Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion. | Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion.
Hill L, Ebert A, Jaritz M, Wutz G, Nagasaka K, Tagoh H, Kostanova-Poliakova D, Schindler K, Sun Q, Bönelt P, Fischer M, Peters JM, Busslinger M., Free PMC Article | 09/5/2020 |
| Gene expression analysis of mouse models and primary human leukemia suggested that reduced function of PAX5 increased the ability of an oncogenic form of IKZF1 or ETV6-AML to modulate gene expression. Data reveals that PAX5 belong to a regulatory network frequently targeted by multiple mutations in B-lineage acute lymphoblastic leukemia shedding light on the molecular interplay in leukemia cells. | PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.
Okuyama K, Strid T, Kuruvilla J, Somasundaram R, Cristobal S, Smith E, Prasad M, Fioretos T, Lilljebjörn H, Soneji S, Lang S, Ungerbäck J, Sigvardsson M., Free PMC Article | 01/11/2020 |
| Loss of Pax5 drives metabolic reprogramming, which together with Sca1-restricted BCR-ABL expression enables leukemic transformation. | Loss of Pax5 Exploits Sca1-BCR-ABL(p190) Susceptibility to Confer the Metabolic Shift Essential for pB-ALL.
Martín-Lorenzo A, Auer F, Chan LN, García-Ramírez I, González-Herrero I, Rodríguez-Hernández G, Bartenhagen C, Dugas M, Gombert M, Ginzel S, Blanco O, Orfao A, Alonso-López D, Rivas JL, García-Cenador MB, García-Criado FJ, Müschen M, Sánchez-García I, Borkhardt A, Vicente-Dueñas C, Hauer J., Free PMC Article | 06/15/2019 |
| we show that the transcription factor Paired box 5 (Pax5) is critical for the establishment and maintenance of the global lineage-specific architecture of B cells. | Transcription-factor-mediated supervision of global genome architecture maintains B cell identity.
Johanson TM, Lun ATL, Coughlan HD, Tan T, Smyth GK, Nutt SL, Allan RS. | 04/27/2019 |
| Findings support the notion of a targeting mechanism for the selective diversification of antibody genes with limited genome wide mutagenesis by recruitment of Activation-induced cytidine deaminase by PAX5 and ETS1 in a transcription factor complex. | ETS1 and PAX5 transcription factors recruit AID to Igh DNA.
Grundström C, Kumar A, Priya A, Negi N, Grundström T. | 04/6/2019 |
| The co-localization of Pax5 and Iba1 was evident in microglia in almost all evaluated regions of brain | Co-Localization and Interaction of Pax5 with Iba1 in Brain of Mice.
Maurya SK, Mishra R. | 09/8/2018 |
| identify Pax5 and cyclin D1 as Zfp521 target genes | Zfp521 promotes B-cell viability and cyclin D1 gene expression in a B cell culture system.
Al Dallal S, Wolton K, Hentges KE., Free PMC Article | 07/22/2017 |
| Together with similar observations made in human PAX5-ETV6(+) B-ALLs, these data identified PAX5-ETV6 fusion as a potent oncoprotein that drives B-cell leukemia development. | Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.
Smeenk L, Fischer M, Jurado S, Jaritz M, Azaryan A, Werner B, Roth M, Zuber J, Stanulla M, den Boer ML, Mullighan CG, Strehl S, Busslinger M., Free PMC Article | 07/15/2017 |
| PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G expression. | Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering β-catenin signalling and GADD45G expression.
Zhao L, Li S, Gan L, Li C, Qiu Z, Feng Y, Li J, Li L, Li C, Peng W, Xu C, Wang Z, Hui T, Ren G, Tao Q, Xiang T., Free PMC Article | 01/14/2017 |
| Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma independent of CCND1. | Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in MCL patients independent of CCND1.
Teo AE, Chen Z, Miranda RN, McDonnell T, Medeiros LJ, McCarty N., Free PMC Article | 07/30/2016 |
| Spleen-specific isoform of Pax5 and Ataxin-7 can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders. | Spleen-specific isoforms of Pax5 and Ataxin-7 as potential proteomic markers of lymphoma-affected spleen.
Bharti B, Mishra R. | 10/31/2015 |
| Pax5 and Ebf1 collaborate to modulate the transcriptional response to Notch signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors. | Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.
Ungerbäck J, Åhsberg J, Strid T, Somasundaram R, Sigvardsson M., Free PMC Article | 09/12/2015 |
| a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 and Pax5 genes, revealing a synergistic effect of combined dose reduction of these proteins | Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.
Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M., Free PMC Article | 09/5/2015 |
| These results show that in contrast to simple Pax5 haploinsufficiency, multiple sequential alterations targeting lymphoid development are central to leukemogenesis and contribute to the arrest in lymphoid maturation characteristic of ALL. | PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.
Dang J, Wei L, de Ridder J, Su X, Rust AG, Roberts KG, Payne-Turner D, Cheng J, Ma J, Qu C, Wu G, Song G, Huether RG, Schulman B, Janke L, Zhang J, Downing JR, van der Weyden L, Adams DJ, Mullighan CG., Free PMC Article | 08/15/2015 |