| Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and beta-arrestin-1 Pathways. | Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and β-arrestin-1 Pathways.
Ni Z, Wang Y, Shi C, Zhang X, Gong H, Dong Y. | 12/10/2022 |
| A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing. | A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.
Dowsett GKC, Lam BYH, Tadross JA, Cimino I, Rimmington D, Coll AP, Polex-Wolf J, Knudsen LB, Pyke C, Yeo GSH., Free PMC Article | 03/26/2022 |
| A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes. | A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes.
Muhsin NIA, Bentley L, Bai Y, Goldsworthy M, Cox RD., Free PMC Article | 12/12/2020 |
| Translation of insulin granule proteins are regulated by PDI and PABP. | Translation of insulin granule proteins are regulated by PDI and PABP.
Sarwade RD, Khalique A, Kulkarni SD, Pandey PR, Gaikwad N, Seshadri V. | 12/5/2020 |
| pancreatic cancer-derived exosomes (Exo-Mia) suppress the synthesis of GIP and GLP-1 from STC-1cells in vitro by down-regulating the PCSK1/3 | Pancreatic cancer-derived exosomes suppress the production of GIP and GLP-1 from STC-1 cells in vitro by down-regulating the PCSK1/3.
Zhang Y, Huang S, Li P, Chen Q, Li Y, Zhou Y, Wang L, Kang M, Zhang B, Yang B, Dong X, Wu Y. | 09/14/2019 |
| Study reveals a significant reduction of tachykinin and opioid neuropeptides level in proprotein convertase 1 and proprotein convertase 2 mutant mouse spinal cords. | Targeted high-resolution quadrupole-Orbitrap mass spectrometry analyses reveal a significant reduction of tachykinin and opioid neuropeptides level in PC1 and PC2 mutant mouse spinal cords.
Saidi M, Beaudry F. | 06/16/2018 |
| Oxygen and glucose deprivation or middle cerebral artery occlusion stress caused substantial cell death in a dose-dependent manner. With the increasing OGD dose, proPC1 and PC1 proteins gradually increased. In vivo the proPC1 and PC1 expressions presented with a peak at 4-h and then decreased at 24-h reperfusion. The results suggest that the increasing PC1 expression promoted the transformation of proCgA into CgA or small | Proprotein convertase 1 mediated proneuropeptide proteolytic processing in ischemic neuron injury.
Tang SS, Liang ZY, Guo LR, Zhang JH, Zhou D. | 03/17/2018 |
| investigation of the pathogenesis of obesity in the PC1/3-N222D mouse model and whether this molecular mechanism also applies to common and rare human PCSK1 mutations | Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.
Stijnen P, Brouwers B, Dirkx E, Ramos-Molina B, Van Lommel L, Schuit F, Thorrez L, Declercq J, Creemers JW. | 01/20/2018 |
| These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1. Moreover, we validated decreased expression of the SNARE complex protein VAMP1 (synaptobrevin-1) in the dHip as well as decreased expression of pro-dynorphin (PDYN), neuroendocrine convertase (PCSK1), and Leu-Enkephalin (dynorphin-A) in the nucleus accumbens | Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter.
Oliveros A, Starski P, Lindberg D, Choi S, Heppelmann CJ, Dasari S, Choi DS., Free PMC Article | 10/21/2017 |
| findings suggest that the major neuroendocrine features of Prader-Willi syndrome are due to PC1 deficiency | Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.
Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL., Free PMC Article | 09/9/2017 |
| macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha, IL6, IL1alpha and CXCL2. | The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways.
Duhamel M, Rodet F, Murgoci AN, Desjardins R, Gagnon H, Wisztorski M, Fournier I, Day R, Salzet M., Free PMC Article | 12/31/2016 |
| PC1 and PC2 are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 protein | Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions.
Saidi M, Kamali S, Ruiz AO, Beaudry F. | 08/27/2016 |
| Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage. | Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
Miyamoto A, Donovan LJ, Perez E, Connett B, Cervantes R, Lai K, Withers G, Hogrebe G. | 08/22/2015 |
| Data indicate that the mutant PC1/3-N222D protein coimmunoprecipitates with wildtype(WT) prohormone convertase 1/3 (PC1/3) and exerts a modest effect on intracellular retention of the WT enzyme. | Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.
Prabhu Y, Blanco EH, Liu M, Peinado JR, Wheeler MC, Gekakis N, Arvan P, Lindberg I., Free PMC Article | 08/30/2014 |
| proSAAS as a novel down-regulated target of Pax6 | Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.
Liu T, Zhao Y, Tang N, Feng R, Yang X, Lu N, Wen J, Li L., Free PMC Article | 05/11/2013 |
| Loss of PC1 in mice showed a dramatic decrease in the biosynthesis of all proTRH-derived peptides analyzed including TRH and its immediate precursor TRH-Gly. | Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice.
Cyr NE, Stuart RC, Zhu X, Steiner DF, Nillni EA. | 08/11/2012 |
| PC1/3 also has an important role in the regulation of the innate immune system, most likely through the regulation of cytokine secretion in macrophages. | Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.
Refaie S, Gagnon S, Gagnon H, Desjardins R, D'Anjou F, D'Orléans-Juste P, Zhu X, Steiner DF, Seidah NG, Lazure C, Salzet M, Day R., Free PMC Article | 07/7/2012 |
| Reports demonstrate that mouse proprotein convertase 1/3 (mPC1/3) has a lag phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis. | Hysteretic behavior of proprotein convertase 1/3 (PC1/3).
Icimoto MY, Barros NM, Ferreira JC, Marcondes MF, Andrade D, Machado MF, Juliano MA, Júdice WA, Juliano L, Oliveira V., Free PMC Article | 03/3/2012 |
| Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of ss-cell regeneration. | Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration.
Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M., Free PMC Article | 04/2/2011 |
| Data suggest that PC1/3 and many convertase-specific properties are attributable less to convertase-specific catalytic cleft residues than to convertase-specific domain interactions. | Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis.
Ozawa A, Peinado JR, Lindberg I., Free PMC Article | 10/23/2010 |
| These results demonstrate a prominent role for cathepsin L, jointly with PC1/3 and PC2, for production of dynorphins in brain. | Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression.
Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. | 05/3/2010 |
| PC1 expression can promote normal and neoplastic mammary development and growth and suggests that proprotein convertases may be important etiological factors in human breast neoplasia | Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice.
Blanchard A, Iwasiow B, Yarmill A, Fresnosa A, Silha J, Myal Y, Murphy LC, Chrétien M, Seidah N, Shiu RP. | 03/8/2010 |
| The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin. | Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.
Takahashi T, Ida T, Sato T, Nakashima Y, Nakamura Y, Tsuji A, Kojima M. | 02/8/2010 |
| These results provide a structure-function analysis of a dense core secretory granules -sorting domain of PC1/3 protease. | Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease.
Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P, Reudelhuber TL, Omichinski JG., Free PMC Article | 01/21/2010 |
| Regulation and role of PC1 by corticotropin-releasing factor in mouse pituitary | Regulation and role of p21-activated kinase 3 by corticotropin-releasing factor in mouse pituitary.
Kageyama K, Sakihara S, Suda T. | 01/21/2010 |