| Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice. | Cartilage tissues regulate systemic aging via ectonucleotide pyrophosphatase/phosphodiesterase 1 in mice.
Arima T, Sugimoto K, Taniwaki T, Maeda K, Shibata Y, Tateyama M, Karasugi T, Tokunaga T, Sueyoshi T, Hisanaga S, Masuda T, Uehara Y, Yugami M, Matsushita K, Yonemitsu R, Kawakami J, Yoshimura N, Tanimura S, Kato H, Ito N, Inoue K, Bando K, Nakamura T, Miyamoto T., Free PMC Article | 02/7/2024 |
| HER2Delta16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer. | HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer.
Attalla SS, Boucher J, Proud H, Taifour T, Zuo D, Sanguin-Gendreau V, Ling C, Johnson G, Li V, Luo RB, Kuasne H, Papavasiliou V, Walsh LA, Barok M, Joensuu H, Park M, Roux PP, Muller WJ. | 09/6/2023 |
| Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway. | Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway.
Gao Z, Wang Q, Guo K, Li X, Huang Y., Free PMC Article | 06/30/2023 |
| ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway. | ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway.
Wang Q, Gao Z, Guo K, Lu J, Wang F, Huang Y, Wu D., Free PMC Article | 10/22/2022 |
| Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass. | Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.
Zimmerman K, Liu X, von Kroge S, Stabach P, Lester ER, Chu EY, Srivastava S, Somerman MJ, Tommasini SM, Busse B, Schinke T, Carpenter TO, Oheim R, Braddock DT., Free PMC Article | 10/1/2022 |
| ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling. | ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling.
Carozza JA, Cordova AF, Brown JA, AlSaif Y, Böhnert V, Cao X, Mardjuki RE, Skariah G, Fernandez D, Li L., Free PMC Article | 05/28/2022 |
| Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice. | Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Roberts FL, Rashdan NA, Phadwal K, Markby GR, Dillon S, Zoll J, Berger J, Milne E, Orriss IR, Karsenty G, Le Saux O, Morton NM, Farquharson C, MacRae VE., Free PMC Article | 10/9/2021 |
| Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice. | Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice.
Ferreira CR, Kavanagh D, Oheim R, Zimmerman K, Stürznickel J, Li X, Stabach P, Rettig RL, Calderone L, MacKichan C, Wang A, Hutchinson HA, Nelson T, Tommasini SM, von Kroge S, Fiedler IA, Lester ER, Moeckel GW, Busse B, Schinke T, Carpenter TO, Levine MA, Horowitz MC, Braddock DT., Free PMC Article | 09/18/2021 |
| Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency. | Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency.
Oheim R, Zimmerman K, Maulding ND, Stürznickel J, von Kroge S, Kavanagh D, Stabach PR, Kornak U, Tommasini SM, Horowitz MC, Amling M, Thompson D, Schinke T, Busse B, Carpenter TO, Braddock DT., Free PMC Article | 09/18/2021 |
| Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization. | Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization.
Maulding ND, Kavanagh D, Zimmerman K, Coppola G, Carpenter TO, Jue NK, Braddock DT., Free PMC Article | 06/26/2021 |
| ENPP1 deficiency confers an energetic disadvantage to PCs for long-term survival and antibody production. | ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells.
Wang H, Gonzalez-Garcia I, Traba J, Jain S, Conteh S, Shin DM, Qi C, Gao Y, Sun J, Kang S, Abbasi S, Naghashfar Z, Yoon J, DuBois W, Kovalchuk AL, Sack MN, Duffy P, Morse HC 3rd., Free PMC Article | 07/13/2019 |
| Enpp1 plays a crucial role in regulating aging via Klotho expression under phosphate overload conditions. | Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
Watanabe R, Fujita N, Sato Y, Kobayashi T, Morita M, Oike T, Miyamoto K, Kuro-O M, Michigami T, Fukumoto S, Tsuji T, Toyama Y, Nakamura M, Matsumoto M, Miyamoto T., Free PMC Article | 02/23/2019 |
| found that, like NTPDase1 (ectonucleoside triphosphate diphosphohydrolase 1, CD39), NPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1, PC-1) is also highly expressed in primary cultured murine microglia | NPP1 is responsible for potent extracellular ATP hydrolysis as NTPDase1 in primary cultured murine microglia.
Lim HM, Heo W, Han JW, Lee MG, Kim JY., Free PMC Article | 01/26/2019 |
| Enpp1 inhibits hedgehog signaling and chondrocyte hypertrophy by activating Galphas-PKA signaling. | Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.
Jin Y, Cong Q, Gvozdenovic-Jeremic J, Hu J, Zhang Y, Terkeltaub R, Yang Y., Free PMC Article | 01/12/2019 |
| Runt-related transcription factor 2 (Runx2) was confirmed to have synergistic effects with Osx in activating ENPP1 promoter. | Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes.
Gao MM, Su QN, Liang TZ, Ma JX, Liang TZ, Stoddart MJ, Richards RG, Zhou ZY, Zou NX. | 12/29/2018 |
| Report the temporal ectopic mineralization phenotype of connective tissues in Enpp1asj-2J mouse model for generalized arterial calcification of infancy. | Variable patterns of ectopic mineralization in Enpp1asj-2J mice, a model for generalized arterial calcification of infancy.
Siu SY, Dyment NA, Rowe DW, Sundberg JP, Uitto J, Li Q., Free PMC Article | 02/24/2018 |
| Evidence of a causative link between ENPP1 and alterations in insulin signaling, glucose uptake, and lipid metabolism in subcutaneous abdominal Adipose tissue of gestational diabetes, which may mediate insulin resistance and hyperglycemia in Gestational diabetes. | Adipose Tissue Insulin Resistance in Gestational Diabetes.
Tumurbaatar B, Poole AT, Olson G, Makhlouf M, Sallam HS, Thukuntla S, Kankanala S, Ekhaese O, Gomez G, Chandalia M, Abate N., Free PMC Article | 11/18/2017 |
| Results show that urine pyrophosphate (PPI) levels are increased in Npt2a-/- mice when compared to WT, possibly to protect from renal mineralization in the setting of hyperphosphaturia. However, the presence of two hypomorphic Enpp1asj/asj alleles decreases urine PPi and worsens renal calcium phosphate deposit formation in Npt2a-/- mice. | Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice.
Caballero D, Li Y, Fetene J, Ponsetto J, Chen A, Zhu C, Braddock DT, Bergwitz C., Free PMC Article | 09/23/2017 |
| Enpp1asj mutant mouse provides a new animal model for studying tympanosclerotic otitis and otitis media with effusion | Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis.
Tian C, Harris BS, Johnson KR., Free PMC Article | 07/15/2017 |
| identified ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) as the first known mammalian enzyme lacking a NUDIX domain to generate pR from ADP-ribose on modified proteins in vitro | ENPP1 processes protein ADP-ribosylation in vitro.
Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I., Free PMC Article | 07/1/2017 |
| Vitamin D3 regulates Enpp1 expression, which presumably, in the context of adequate tissue non-specific alkaline phosphatase activity, provides phosphate to stimulate mineralisation. | 1,25-Dihydroxyvitamin D3 and extracellular calcium promote mineral deposition via NPP1 activity in a mature osteoblast cell line MLO-A5.
Yang D, Turner AG, Wijenayaka AR, Anderson PH, Morris HA, Atkins GJ. | 05/21/2016 |
| ENPP1-Fc fusion protein prevents the mortality, vascular calcifications and sequela of disease in mouse models of generalized arterial calcification of infancy. | ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy.
Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT., Free PMC Article | 05/14/2016 |
| Expression of NPP1 and 5'-nucleotidase by valve interstitial cells promotes the mineralization of the aortic valve through A2aR and a cAMP/PKA/CREB pathway. | Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor.
Mahmut A, Boulanger MC, Bouchareb R, Hadji F, Mathieu P. | 02/13/2016 |
| Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions. | Acidosis is a key regulator of osteoblast ecto-nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity.
Orriss IR, Key ML, Hajjawi MO, Millán JL, Arnett TR., Free PMC Article | 11/21/2015 |
| NPP1 has a role in obesity and diabetes in a mouse model | Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes.
Huesa C, Zhu D, Glover JD, Ferron M, Karsenty G, Milne EM, Millan JL, Ahmed SF, Farquharson C, Morton NM, MacRae VE., Free PMC Article | 08/29/2015 |