| Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer. | Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer.
Chaib M, Holt JR, Fisher EL, Sipe LM, Bohm MS, Joseph SC, Simmons BW, Eugin Simon S, Yarbro JR, Tanveer U, Halle JL, Carson JA, Hollingsworth TJ, Wei Q, Rathmell JC, Thomas PG, Hayes DN, Makowski L., Free PMC Article | 01/3/2024 |
| Loss of PKCdelta/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model. | Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model.
Singh G, O-Sullivan I, Natarajan Anbazhagan A, Ranjan K C, Farooqui Z, Ma K, Wang J, Mwale F, Votta-Velis G, Bruce B, Ronald Kahn C, van Wijnen AJ, Im HJ. | 11/30/2023 |
| The metabolomics of a protein kinase C delta (PKCdelta) knock-out mouse model. | The metabolomics of a protein kinase C delta (PKCδ) knock-out mouse model.
Loots DT, Adeniji AA, Van Reenen M, Ozturk M, Brombacher F, Parihar SP., Free PMC Article | 11/19/2022 |
| Inhibition of PKC-delta reduce rhabdomyolysis-induced acute kidney injury. | Inhibition of PKC-δ reduce rhabdomyolysis-induced acute kidney injury.
Wu D, Pan J, Zhang D., Free PMC Article | 06/11/2022 |
| PKCdelta-positive GABAergic neurons in the central amygdala exhibit tissue-type plasminogen activator: role in the control of anxiety. | PKCδ-positive GABAergic neurons in the central amygdala exhibit tissue-type plasminogen activator: role in the control of anxiety.
Douceau S, Lemarchand E, Hommet Y, Lebouvier L, Joséphine C, Bemelmans AP, Maubert E, Agin V, Vivien D. | 05/28/2022 |
| SMS2 deficiency impairs PKCdelta-regulated B cell tolerance in the germinal center. | SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center.
Ou P, Stanek A, Huan Z, Roman CAJ, Huan C. | 02/19/2022 |
| Protein kinase Cdelta is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria. | Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria.
Fukao S, Haniuda K, Tamaki H, Kitamura D., Free PMC Article | 01/29/2022 |
| TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) delta/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice. | TREM (Triggering Receptor Expressed on Myeloid Cells)-1 Inhibition Attenuates Neuroinflammation via PKC (Protein Kinase C) δ/CARD9 (Caspase Recruitment Domain Family Member 9) Signaling Pathway After Intracerebral Hemorrhage in Mice.
Lu Q, Liu R, Sherchan P, Ren R, He W, Fang Y, Huang Y, Shi H, Tang L, Yang S, Zhang JH, Tang J., Free PMC Article | 01/8/2022 |
| PKCdelta deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCdelta knockout mice. | PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice.
Niino YS, Kawashima I, Iguchi Y, Kanda H, Ogura K, Mita-Yoshida K, Ono T, Yamazaki M, Sakimura K, Yogosawa S, Yoshida K, Shioda S, Gotoh T., Free PMC Article | 11/22/2021 |
| Protein kinase Cdelta as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice.
He Y, Shi Z, Kashyap Y, Messing RO, Wang ZJ., Free PMC Article | 10/30/2021 |
| Endothelial deletion of PKCdelta prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb. | Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischemic limb.
Croteau L, Mercier C, Fafard-Couture É, Nadeau A, Robillard S, Breton V, Guay A, Lizotte F, Despatis MA, Geraldes P., Free PMC Article | 09/4/2021 |
| Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H2O2-Activated Protein Kinase C-delta Signaling. | Cardiac Ischemic Preconditioning Promotes MG53 Secretion Through H(2)O(2)-Activated Protein Kinase C-δ Signaling.
Shan D, Guo S, Wu HK, Lv F, Jin L, Zhang M, Xie P, Wang Y, Song Y, Wu F, Lan F, Hu X, Cao CM, Zhang Y, Xiao RP. | 09/4/2021 |
| Protein kinase C-delta interacts with and phosphorylates ARD1. | Protein kinase C-δ interacts with and phosphorylates ARD1.
Chun KH, Cho SJ, Lee JW, Seo JH, Kim KW, Lee SK. | 08/28/2021 |
| Phosphorylation of protein kinase Cdelta Tyr311 positively regulates thromboxane generation in platelets. | Phosphorylation of protein kinase Cδ Tyr311 positively regulates thromboxane generation in platelets.
Kostyak JC, Mauri B, Patel A, Dangelmaier C, Reddy H, Kunapuli SP., Free PMC Article | 08/21/2021 |
| Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCdelta in Astrocytes: Implications for Parkinson's Disease. | Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson's Disease.
Samidurai M, Tarale P, Janarthanam C, Estrada CG, Gordon R, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A., Free PMC Article | 03/13/2021 |
| Protein Kinase C-delta Mediates Kidney Tubular Injury in Cold Storage-Associated Kidney Transplantation. | Protein Kinase C-δ Mediates Kidney Tubular Injury in Cold Storage-Associated Kidney Transplantation.
Zhu J, Zhang G, Song Z, Xiang X, Shu S, Liu Z, Yang D, Wei Q, Dong Z., Free PMC Article | 01/2/2021 |
| Specific targeting of PKCdelta suppresses osteoclast differentiation by accelerating proteolysis of membrane-bound macrophage colony-stimulating factor receptor. | Specific targeting of PKCδ suppresses osteoclast differentiation by accelerating proteolysis of membrane-bound macrophage colony-stimulating factor receptor.
Kim MY, Lee K, Shin HI, Jeong D., Free PMC Article | 11/21/2020 |
| PKCdelta tyrosine 155 is a key phosphorylation site controlling proinflammatory signaling and neutrophil-endothelial cell interactions | Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation.
Soroush F, Tang Y, Guglielmo K, Engelmann A, Liverani E, Patel A, Langston J, Sun S, Kunapuli S, Kiani MF, Kilpatrick LE., Free PMC Article | 06/13/2020 |
| asprosin results in impairment of insulin sensitivity in skeletal muscle through PKCdelta-associated endoplasmic reticulum stress/inflammation pathways. | Asprosin attenuates insulin signaling pathway through PKCδ-activated ER stress and inflammation in skeletal muscle.
Jung TW, Kim HC, Kim HU, Park T, Park J, Kim U, Kim MK, Jeong JH. | 06/6/2020 |
| PKCdelta deletion protected mice from cardiac dysfunction after sepsis. PKCdelta causes mitochondrial dysfunction in cardiac myocytes, and reducing mitochondrial oxidative stress improves contractility in wild-type cardiomyocytes. | PKCδ causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction.
Joseph LC, Reyes MV, Lakkadi KR, Gowen BH, Hasko G, Drosatos K, Morrow JP., Free PMC Article | 05/30/2020 |
| Atg7 mediates vancomycin-induced acute kidney injury through the activation of PKCdelta. Following Van treatment, PKC-delta expression was found to be highest among the 4 genes related to cell death, which was remarkably suppressed in vitro and in PT-Atg7-KO mice. In addition, Atg7 could induce renal cell apoptosis during Van treatment via binding to PKC-delta. | Atg7 mediates renal tubular cell apoptosis in vancomycin nephrotoxicity through activation of PKC-δ.
Xu X, Pan J, Li H, Li X, Fang F, Wu D, Zhou Y, Zheng P, Xiong L, Zhang D. | 05/16/2020 |
| The findings of the present study demonstrate a previously unidentified mechanism by which PKC- delta via activation of SSH1 and cofilin dephosphorylation stimulates membrane ruffle formation and macropinocytosis. | PKCδ stimulates macropinocytosis via activation of SSH1-cofilin pathway.
Singla B, Lin HP, Ghoshal P, Cherian-Shaw M, Csányi G., Free PMC Article | 02/29/2020 |
| Study using macrophages of PKC delta knockout mice, revealed that IL-1beta and IL-6 mRNA transcription and protein expression levels were significantly decreased after Mycobacterium tuberculosis toxins stimulation, indicating that in macrophages PKC delta was involved in the production of anti-mycobacterial cytokines. | PKC δ gene can induce macrophages to release inflammatory factors against Mycobacterium tuberculosis infection.
Duan YT, Bi KY, Ma YS. | 12/14/2019 |
| these data identify PKCdelta as a critical regulator of HSPC signaling and metabolism that acts to limit HSPC expansion in response to physiological and regenerative demands. | Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.
Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ., Free PMC Article | 10/5/2019 |
| c-Src-mediated regulation of Nrf2 transcriptional activity, via PKCdelta activation. | c-Src regulates Nrf2 activity through PKCδ after oxidant stimulus.
Fão L, Mota SI, Rego AC. | 09/14/2019 |