The lack of PPARα exacerbated the progression of non-alcoholic steatohepatitis in mice with spleen deficiency syndrome by triggering an inflammatory response.
Huang J, Li J, Peng Y, Cui T, Guo J, Duan S, Zhou K, Huang S, Chen J, Yi Q, Qiu M, Chen T, Wu X, Ma C, Zhang Z, Zheng Y, Tang X, Pang Y, Zhang L, Zhong C, Gao Y., Free PMC Article

Staphylococcus aureus oleate hydratase produces ligands that activate host PPARα.
Radka CD, Frank MW, Simmons TS, Johnson CN, Rosch JW, Rock CO., Free PMC Article

PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells.
Ke Q, Xiao Y, Liu D, Shi C, Shen R, Qin S, Jiang L, Yang J, Zhou Y.

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis.
Dong J, Li M, Peng R, Zhang Y, Qiao Z, Sun N., Free PMC Article

The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα.
Clavreul L, Bernard L, Cotte AK, Hennuyer N, Bourouh C, Devos C, Helleboid A, Haas JT, Verrijken A, Gheeraert C, Derudas B, Guille L, Chevalier J, Eeckhoute J, Vallez E, Dorchies E, Van Gaal L, Lassailly G, Francque S, Staels B, Paumelle R.

PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice.
Hempel B, Crissman M, Pari S, Klein B, Bi GH, Alton H, Xi ZX., Free PMC Article

Role of PPARα in inflammatory response of C2C12 myotubes.
Shimizu Y, Hamada K, Guo T, Hasegawa C, Kuga Y, Takeda K, Yagi T, Koyama H, Takagi H, Aotani D, Kataoka H, Tanaka T.

Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury.
Kim H, Lee SK, Hong S, Park TS, Kim J, Kim S, Kim TM., Free PMC Article

PPARα/γ synergism activates UCP1-dependent and -independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice.
Miranda CS, Silva-Veiga FM, Santana-Oliveira DA, Vasques-Monteiro IML, Daleprane JB, Souza-Mello V.

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.
Onodera T, Kim DS, Ye R, Wang MY, Chen S, Field BC, Straub L, Sun XN, Li C, Lee C, Paredes M, Crewe C, Zhao S, Kusminski CM, Gordillo R, Scherer PE., Free PMC Article

Inflammation-induced nitric oxide suppresses PPARα expression and function via downregulation of Sp1 transcriptional activity in adipocytes.
Kwon J, Aoki Y, Takahashi H, Nakata R, Kawarasaki S, Ni Z, Yu R, Inoue H, Inoue K, Kawada T, Goto T.

Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation.
Zhou Y, Li L, Chen X, Zhao Q, Qu N, Zhang B, Jin X, Xia C., Free PMC Article

Pparα knockout in mice increases the Th17 development by facilitating the IKKα/RORγt and IKKα/Foxp3 complexes.
Wei P, Kou W, Fu J, Chen Z, Pan F., Free PMC Article

PPARα is involved in high-fat diet-induced risk avoidance impairment via the regulation of hippocampal BDNF.
Zhu XY, Luo J, Wei XJ, Pan LH, Xu XF, Hu LB, Dong YB, Jiang YK, Dong FY, Xu L, Xu LM, Liu AM, Zhang XQ.

Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease.
Badmus OO, Kipp ZA, Bates EA, da Silva AA, Taylor LC, Martinez GJ, Lee WH, Creeden JF, Hinds TD Jr, Stec DE.,

Peroxisome proliferator-activated receptor-α activation facilitates contextual fear extinction and modulates intrinsic excitability of dentate gyrus neurons.
Xiang G, Liu X, Wang J, Lu S, Yu M, Zhang Y, Sun B, Huang B, Lu XY, Li X, Zhang D., Free PMC Article

Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism.
Chougule A, Baroi S, Czernik PJ, Crowe E, Chang MR, Griffin PR, Lecka-Czernik B., Free PMC Article

PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice.
Kasano-Camones CI, Takizawa M, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y., Free PMC Article

Peroxisome proliferator-activated receptor-α (PPARα) regulates wound healing and mitochondrial metabolism in the cornea.
Liang W, Huang L, Whelchel A, Yuan T, Ma X, Cheng R, Takahashi Y, Karamichos D, Ma JX., Free PMC Article

Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease.
Rangasamy SB, Jana M, Dasarathi S, Kundu M, Pahan K., Free PMC Article

The Protective Role of Microglial PPARα in Diabetic Retinal Neurodegeneration and Neurovascular Dysfunction.
Yuan T, Dong L, Pearsall EA, Zhou K, Cheng R, Ma JX., Free PMC Article

SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.
Lee B, An HJ, Kim DH, Lee MK, Jeong HH, Chung KW, Go Y, Seo AY, Kim IY, Seong JK, Yu BP, Lee J, Im E, Lee IK, Lee MS, Yamada KI, Chung HY., Free PMC Article

Modulation of cGAS-STING signaling by PPARα in a mouse model of ischemia-induced retinopathy.
Ma X, Wu W, Liang W, Takahashi Y, Cai J, Ma JX., Free PMC Article

Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy.
Qiu Z, Zhao Y, Tao T, Guo W, Liu R, Huang J, Xu G., Free PMC Article

Reduced peroxisome proliferator-activated receptor-α and bile acid nuclear receptor NR1H4/FXR may affect the hepatic immune microenvironment of biliary atresia.
Ma Y, Lu L, Tan K, Li Z, Guo T, Wu Y, Wu W, Zheng L, Fan F, Mo J, Gong Z., Free PMC Article