| PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas. | PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomas.
Shen J, Yang J, Sang L, Sun R, Bai W, Wang C, Sun Y, Sun J., Free PMC Article | 10/1/2022 |
| [Time dependent expression profiling of PTK2B and its relationship with Abeta, Tau and LRP-1 in hippocampus and blood of APPswe/PS1dE9 double-transgenic mouse]. | [Time dependent expression profiling of PTK2B and its relationship with Aβ, Tau and LRP-1 in hippocampus and blood of APPswe/PS1dE9 double-transgenic mouse].
Hao KM, Liu Z, Wang HY, Qi WX. | 06/11/2022 |
| Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis. | Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis.
Momi S, Canino J, Vismara M, Galgano L, Falcinelli E, Guglielmini G, Taranta GC, Guidetti GF, Gresele P, Torti M, Canobbio I., Free PMC Article | 06/11/2022 |
| Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy. | Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.
Brody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM., Free PMC Article | 05/14/2022 |
| Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons. | Pyk2 Regulates MAMs and Mitochondrial Dynamics in Hippocampal Neurons.
López-Molina L, Fernández-Irigoyen J, Cifuentes-Díaz C, Alberch J, Girault JA, Santamaría E, Ginés S, Giralt A., Free PMC Article | 04/16/2022 |
| Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk. | Pyk2 regulates cell-edge protrusion dynamics by interacting with Crk.
Lukic N, Lapetina S, Grobe H, Srikanth KD, Twafra S, Solomon J, Sneh T, Gendler M, Zaidel-Bar R, Gil-Henn H., Free PMC Article | 03/26/2022 |
| Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner. | Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner.
Zheng J, Suo L, Zhou Y, Jia L, Li J, Kuang Y, Cui D, Zhang X, Wu Q., Free PMC Article | 03/19/2022 |
| Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells. | Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells.
Day RN, Day KH, Pavalko FM., Free PMC Article | 01/15/2022 |
| Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding sitedagger. | Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site†.
Wang H, Hong X, Kinsey WH., Free PMC Article | 01/8/2022 |
| Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation. | Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Ryzhakov G, Almuttaqi H, Corbin AL, Berthold DL, Khoyratty T, Eames HL, Bullers S, Pearson C, Ai Z, Zec K, Bonham S, Fischer R, Jostins-Dean L, Travis SPL, Kessler BM, Udalova IA., Free PMC Article | 01/1/2022 |
| Pyk2 in dorsal hippocampus plays a selective role in spatial memory and synaptic plasticity. | Pyk2 in dorsal hippocampus plays a selective role in spatial memory and synaptic plasticity.
Mastrolia V, Al Massadi O, de Pins B, Girault JA., Free PMC Article | 11/13/2021 |
| Pyruvate Kinase M2 Contributes to TLR-Mediated Inflammation and Autoimmunity by Promoting Pyk2 Activation. | Pyruvate Kinase M2 Contributes to TLR-Mediated Inflammation and Autoimmunity by Promoting Pyk2 Activation.
Zhang X, Yang Y, Jing L, Zhai W, Zhang H, Ma Q, Li C, Yan F, Cheng D, Zhang J, Ning Z, Shi H, Wang C, Zhao M, Dai J, Li Z, Ming J, Yu M, Wang H, Cheng H, Xiong H, Dong G., Free PMC Article | 10/30/2021 |
| Roles of Pyk2 in signal transduction after gonadotropin-releasing hormone receptor stimulation. | Roles of Pyk2 in signal transduction after gonadotropin-releasing hormone receptor stimulation.
Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Higashiyama S, Yamamoto H. | 09/25/2021 |
| Ptk2b deletion improves mice folliculogenesis and fecundity via inhibiting follicle loss mediated by Erk pathway. | Ptk2b deletion improves mice folliculogenesis and fecundity via inhibiting follicle loss mediated by Erk pathway.
Cong Y, Wu H, Bian X, Xie Q, Lyu Q, Cui J, Suo L, Kuang Y. | 09/11/2021 |
| Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor. | Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
Higa-Nakamine S, Okitsu-Sakurayama S, Kina S, Yamamoto H. | 05/22/2021 |
| Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. | Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis.
Kim J, Kang W, Kang SH, Park SH, Kim JY, Yang S, Ha SY, Paik YH., Free PMC Article | 03/20/2021 |
| The proline-rich tyrosine kinase Pyk2 modulates integrin-mediated neutrophil adhesion and reactive oxygen species generation. | The proline-rich tyrosine kinase Pyk2 modulates integrin-mediated neutrophil adhesion and reactive oxygen species generation.
Canino J, Guidetti GF, Galgano L, Vismara M, Minetti G, Torti M, Canobbio I. | 12/12/2020 |
| The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens. | The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens.
de Pins B, Montalban E, Vanhoutte P, Giralt A, Girault JA., Free PMC Article | 11/28/2020 |
| Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair. | Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair.
Thomas KS, Owen KA, Conger K, Llewellyn RA, Bouton AH, Casanova JE., Free PMC Article | 10/10/2020 |
| The current study uncovers PYK2 as a novel downstream effector of mutant KRAS signaling, a previously unrecognized mediator of pancreatitis-induced ADM and a novel intervention target for PDAC. | PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-Catenin(Y654).
Gao C, Chen G, Zhang DH, Zhang J, Kuan SF, Hu W, Esni F, Gao X, Guan JL, Chu E, Hu J., Free PMC Article | 07/25/2020 |
| CaM kinase II activated the ERK pathway through Pyk2 activation and HB-EGF production in response to GnRH. | Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells.
Okitsu-Sakurayama S, Higa-Nakamine S, Torihara H, Takahashi H, Higashiyama S, Yamamoto H. | 04/4/2020 |
| Study shows that brain Pyk2 interacts with the RhoGAP protein Graf1 to alter dendritic spine stability via RhoA GTPase. Amyloid-beta oligomer-induced dendritic spine loss requires the Pyk2/Graf1 pathway. | Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.
Lee S, Salazar SV, Cox TO, Strittmatter SM., Free PMC Article | 03/28/2020 |
| In transgenic Alzheimer's disease model mice, deletion of Pyk2 rescues synaptic loss and learning/memory deficits | Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.
Salazar SV, Cox TO, Lee S, Brody AH, Chyung AS, Haas LT, Strittmatter SM., Free PMC Article | 12/21/2019 |
| Urinary tract pacemaker cells expressing cKIT and the neural crest markers Sox10 and Tfap-2alpha were enriched for RNA encoding PTK2b. PTK2b was expressed in neural crest cells at embryonic day 15.5 and utPMCs until postnatal week 8. Inhibiting PTK2b inhibited contraction of pyeloureteral tissue. PTK2beta contributes to utPMC function. | Protein Kinase 2β Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction.
Iskander SM, Feeney MM, Yee K, Rosenblum ND., Free PMC Article | 09/21/2019 |
| Pyk2 is involved in the process of colonic smooth muscle contraction through the RhoA/ROCK pathway. | Tyrosine kinase Pyk2 is involved in colonic smooth muscle contraction via the RhoA/ROCK pathway.
Tong L, Ao JP, Lu HL, Huang X, Zang JY, Liu SH, Song NN, Huang SQ, Lu C, Chen J, Xu WX. | 06/29/2019 |