| Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha. | Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
Hata K, Tsubouchi K, Suzuki K, Eto D, Ando H, Yanagihara T, Kan-O K, Okamoto I., Free PMC Article | 02/1/2024 |
| SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer. | SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
Wang B, Pan L, Chen M, Ma Y, Gao J, Tang D, Jiang Z. | 11/3/2023 |
| Blocking the CD47-SIRPalpha interaction reverses the disease phenotype in a polycythemia vera mouse model. | Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.
Lysenko V, Schürch PM, Tuzlak S, van Wijk NW, Kovtonyuk LV, Becher B, Manz MG, Kreutmair S, Theocharides APA., Free PMC Article | 06/13/2023 |
| Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina. | Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
Jiang D, Burger CA, Akhanov V, Liang JH, Mackin RD, Albrecht NE, Andrade P, Schafer DP, Samuel MA., Free PMC Article | 12/24/2022 |
| SIRPalpha maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis. | SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
Wang D, Lin Y, Xu F, Zhang H, Zhu X, Liu Z, Hu Y, Dong G, Sun B, Yu Y, Ma G, Tang Z, Legarda D, Ting A, Liu Y, Hou J, Dong L, Xiong H., Free PMC Article | 11/29/2022 |
| SIRPalpha Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease. | SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
Thomas SS, Wu J, Davogustto G, Holliday MW, Eckel-Mahan K, Verzola D, Garibotto G, Hu Z, Mitch WE, Taegtmeyer H., Free PMC Article | 07/30/2022 |
| Endothelial SIRPalpha signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells. | Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
Ren B, Xia H, Liao Y, Zhou H, Wang Z, Shi Y, Zhu M., Free PMC Article | 05/14/2022 |
| SIRPalpha - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen. | SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
Autio A, Wang H, Velázquez F, Newton G, Parkos CA, Engel P, Engelbertsen D, Lichtman AH, Luscinskas FW., Free PMC Article | 04/30/2022 |
| Augmentation of CD47/SIRPalpha signaling protects cones in genetic models of retinal degeneration. | Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.
Wang SK, Xue Y, Cepko CL., Free PMC Article | 04/23/2022 |
| Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha. | Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
De Vlaminck K, Romão E, Puttemans J, Pombo Antunes AR, Kancheva D, Scheyltjens I, Van Ginderachter JA, Muyldermans S, Devoogdt N, Movahedi K, Raes G., Free PMC Article | 02/12/2022 |
| Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPalpha in neurons. | Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons.
Jingu D, Iino M, Kawasaki J, Urano E, Kusakari S, Hayashi Y, Matozaki T, Ohnishi H. | 11/27/2021 |
| The Ap-2alpha/Elk-1 axis regulates Sirpalpha-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer. | The Ap-2α/Elk-1 axis regulates Sirpα-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer.
Wang X, Luo X, Chen C, Tang Y, Li L, Mo B, Liang H, Yu S., Free PMC Article | 10/16/2021 |
| The SIRPalpha-CD47 immune checkpoint in NK cells. | The SIRPα-CD47 immune checkpoint in NK cells.
Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S., Free PMC Article | 09/18/2021 |
| Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. | Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.
Sarute N, Cheng H, Yan Z, Salas-Briceno K, Richner J, Rong L, Ross SR., Free PMC Article | 07/10/2021 |
| Intratumoral SIRPalpha-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy. | Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.
Bian Z, Shi L, Kidder K, Zen K, Garnett-Benson C, Liu Y., Free PMC Article | 06/12/2021 |
| SIRPalpha on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production. | SIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production.
Franke K, Pillai SY, Hoogenboezem M, Gijbels MJJ, Matlung HL, Geissler J, Olsman H, Pottgens C, van Gorp PJ, Ozsvar-Kozma M, Saito Y, Matozaki T, Kuijpers TW, Hendriks RW, Kraal G, Binder CJ, de Winther MPJ, van den Berg TK., Free PMC Article | 06/5/2021 |
| Loss of microglial SIRPalpha promotes synaptic pruning in preclinical models of neurodegeneration. | Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.
Ding X, Wang J, Huang M, Chen Z, Liu J, Zhang Q, Zhang C, Xiang Y, Zen K, Li L., Free PMC Article | 04/24/2021 |
| CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis. | CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Morrissey MA, Kern N, Vale RD., Free PMC Article | 04/17/2021 |
| Inflammation Unrestrained by SIRPalpha Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-gamma. | Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.
Kidder K, Bian Z, Shi L, Liu Y., Free PMC Article | 04/17/2021 |
| HSF1 promotes the viability of islet beta-cells via upregulating SIRPalpha expression. | HSF1 promotes the viability of islet β-cells via upregulating SIRPα expression.
Zhang HM, Yang M, Zhang XY, Tang Y, Wu JL, Huang J. | 03/20/2021 |
| Selective SIRPalpha blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance. | Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.
Gauttier V, Pengam S, Durand J, Biteau K, Mary C, Morello A, Néel M, Porto G, Teppaz G, Thepenier V, Danger R, Vince N, Wilhelm E, Girault I, Abes R, Ruiz C, Trilleaud C, Ralph K, Trombetta ES, Garcia A, Vignard V, Martinet B, Glémain A, Bruneau S, Haspot F, Dehmani S, Duplouye P, Miyasaka M, Labarrière N, Laplaud D, Le Bas-Bernardet S, Blanquart C, Catros V, Gouraud PA, Archambeaud I, Aublé H, Metairie S, Mosnier JF, Costantini D, Blancho G, Conchon S, Vanhove B, Poirier N., Free PMC Article | 02/20/2021 |
| SIRPalpha on CD11c(+) cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis. | SIRPα on CD11c(+) cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis.
Nishimura T, Saito Y, Washio K, Komori S, Respatika D, Kotani T, Murata Y, Ohnishi H, Mizobuchi S, Matozaki T. | 01/16/2021 |
| Signal regulatory protein alpha protects podocytes through promoting autophagic activity. | Signal regulatory protein α protects podocytes through promoting autophagic activity.
Li L, Liu Y, Li S, Yang R, Zeng C, Rong W, Liang H, Zhang M, Zhu X, Kidder K, Liu Y, Liu Z, Zen K., Free PMC Article | 09/26/2020 |
| SIRPalpha inhibits myelin debris phagocytosis in macrophages present in Wallerian degeneration that follows nerve crush injury | Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.
Elberg G, Liraz-Zaltsman S, Reichert F, Matozaki T, Tal M, Rotshenker S., Free PMC Article | 07/18/2020 |
| SIRPalpha(+) DCs are important for the proliferation and differentiation of Pdpn(+) FRCs in peripheral LNs. | SIRPα(+) dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.
Komori S, Saito Y, Respatika D, Nishimura T, Kotani T, Murata Y, Matozaki T. | 05/30/2020 |