| Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis. | Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis.
Neupane S, Aryal YP, Kwak HJ, Lee SG, Kim TY, Pokharel E, Kim JY, Kim JH, Sohn WJ, An SY, An CH, Jung JK, Ha JH, Yamamoto H, Cho SW, Lee S, Lee Y, Park KK, Min BK, Park C, Kwon TY, Cho SJ, Kim JY. | 01/11/2024 |
| Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment. | Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment.
Yao Z, Dong H, Zhu J, Du L, Luo Y, Liu Q, Liu S, Lin Y, Wang L, Wang S, Wei W, Zhang K, Huang Q, Yu X, Zhao W, Xu H, Qiu X, Pan Y, Huang X, Jim Yeung SC, Zhang D, Zhang H., Free PMC Article | 07/27/2023 |
| PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism. | PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G., Free PMC Article | 09/24/2022 |
| Data suggest that tyrosine (Tyr399) in PTPRQ Phosphatase (PTPROt) might participate in regulating the activity of this phosphatase toward src Kinases (Src). | Phosphorylation of the phosphatase PTPROt at Tyr(399) is a molecular switch that controls osteoclast activity and bone mass in vivo.
Roth L, Wakim J, Wasserman E, Shalev M, Arman E, Stein M, Brumfeld V, Sagum CA, Bedford MT, Tuckermann J, Elson A. | 03/28/2020 |
| Using loss-of-function and gain-of-function approaches, we show that PTPRO promotes the formation of excitatory synapses | Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation.
Jiang W, Wei M, Liu M, Pan Y, Cao D, Yang X, Zhang C., Free PMC Article | 10/28/2017 |
| PTPROt thus functions as an obligate haploinsufficient TS in CLL, where its expression levels determine its role as a promoter or inhibitor of the tumorigenic process in mice. Partial loss of PTPROt generates the strongest disease phenotype, suggesting that its intermediate expression levels in CLL are selected for. | The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia.
Wakim J, Arman E, Becker-Herman S, Kramer MP, Bakos E, Shachar I, Elson A. | 10/14/2017 |
| TLR4 and NF-kappaB/p65 phosphorylation was significantly enhanced in PTPRO over-expressing cells, while significantly down-regulated in PTPRO knockout cells. PTPRO plays ital roles in atherosclerosis (AS) via promoting ox-LDL induced oxidative stress and cell apoptosis through TLR4/NF-kappaB pathway. | PTPRO Promotes Oxidized Low-Density Lipoprotein Induced Oxidative Stress and Cell Apoptosis through Toll-Like Receptor 4/Nuclear Factor κB Pathway.
Liang C, Wang X, Hu J, Lian X, Zhu T, Zhang H, Gu N, Li J. | 08/5/2017 |
| PTPRO plays an important role in FH by interacting with TLR4. | Aggravated Liver Injury but Attenuated Inflammation in PTPRO-Deficient Mice Following LPS/D-GaIN Induced Fulminant Hepatitis.
Wang X, Yan S, Xu D, Li J, Xie Y, Hou J, Jiang R, Zhang C, Sun B. | 05/28/2016 |
| Study show that EphA4 is a substrate for PTP-oc in osteoclasts and that the molecular mechanism contributing to the PTP-oc-induced up-regulation of the osteoclast activity in part involves its dephosphorylation and inactivation of the EphA4 signaling. | An Osteoclastic Transmembrane Protein-Tyrosine Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts.
Lau KH, Amoui M, Stiffel V, Chen ST, Sheng MH. | 04/9/2016 |
| PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment. | PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.
Hou J, Deng L, Zhuo H, Lin Z, Chen Y, Jiang R, Chen D, Zhang X, Huang X, Sun B. | 02/20/2016 |
| The loss of PTPRO in the tumor niche was correlated with larger tumor volume, more metastases, increased number of circulating tumor cells, less apoptosis and reduced necrosis rates in the orthotopic mouse model of breast cancer. | Protein tyrosine phosphatase receptor type O expression in the tumor niche correlates with reduced tumor growth, angiogenesis, circulating tumor cells and metastasis of breast cancer.
Liu Z, Hou J, Ren L, He J, Sun B, Sun LZ, Wang S. | 02/6/2016 |
| PTPRO regulates insulin and lipid metabolism via the PI3K/Akt/MDM4/MDM2/P53 axis by affecting autophagy. | PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis.
Zhang W, Hou J, Wang X, Jiang R, Yin Y, Ji J, Deng L, Huang X, Wang K, Sun B., Free PMC Article | 01/30/2016 |
| Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-kappaB activation. | Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-κB activation.
Jiang R, Chen D, Hou J, Tan Z, Wang Y, Huang X, Wang X, Sun B. | 02/28/2015 |
| PTPRO deficiency resulted in reduction of NF-kappaB activation in both hepatocytes and macrophages and was correlated to c-Src phosphorylation. | PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-κB.
Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, Huang X, Wang X, Sun B. | 09/27/2014 |
| PTPRO is expressed mainly in TrkB-expressing (TrkB(+)) and Ret(+) mechanoreceptors within the trigeminal ganglia during embryogenesis. | Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R., Free PMC Article | 06/1/2013 |
| These results suggest that ptpro is a target gene of Wnt/beta-catenin signaling and that PTPRO may function as a novel receptor for Wnt. | Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt.
Kim M, Kim H, Jho EH. | 10/23/2010 |
| Data indicate that PTPRO is required for peptidergic differentiation and process outgrowth of sensory neurons, as well as mature sensory function, and provide the first evidence that RPTPs regulate DRG development. | Protein tyrosine phosphatase receptor type O regulates development and function of the sensory nervous system.
Gonzalez-Brito MR, Bixby JL., Free PMC Article | 04/12/2010 |
| PTPRO might participate in regulation of dendritic morphology or synapse formation of interneurons in the adult mouse olfactory bulb | Expression of PTPRO in the interneurons of adult mouse olfactory bulb.
Kotani T, Murata Y, Ohnishi H, Mori M, Kusakari S, Saito Y, Okazawa H, Bixby JL, Matozaki T., Free PMC Article | 03/1/2010 |
| PTP-oc is a positive regulator of osteoclasts | Targeted transgenic expression of an osteoclastic transmembrane protein-tyrosine phosphatase in cells of osteoclastic lineage increases bone resorption and bone loss in male young adult mice.
Sheng MH, Amoui M, Stiffel V, Srivastava AK, Wergedal JE, Lau KH., Free PMC Article | 01/21/2010 |
| We find that at least one NPCD isoform is tyrosine phosphorylated in vivo and can serve as a substrate for PTPRO in vitro. | A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth.
Chen B, Bixby JL., Free PMC Article | 01/21/2010 |
| PTPRO is involved in the differentiation and axonogenesis of central and peripheral nervous system neurons, where it is in a position to modulate intracellular responses to neurotrophin-3 and/or nerve growth factor. | Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons.
Beltran PJ, Bixby JL, Masters BA. | 01/21/2010 |
| Ptpro moderates the amount of maximal activation of Eph receptors. In the chick retinotectal projection system, Ptpro controls the sensitivity of retinal axons to ephrins. | Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O.
Shintani T, Ihara M, Sakuta H, Takahashi H, Watakabe I, Noda M. | 01/21/2010 |