| The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. | The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V., Free PMC Article | 03/14/2024 |
| Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency. | Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency.
Castiello MC, Brandas C, Ferrari S, Porcellini S, Sacchetti N, Canarutto D, Draghici E, Merelli I, Barcella M, Pelosi G, Vavassori V, Varesi A, Jacob A, Scala S, Basso Ricci L, Paulis M, Strina D, Di Verniere M, Sergi Sergi L, Serafini M, Holland SM, Bergerson JRE, De Ravin SS, Malech HL, Pala F, Bosticardo M, Brombin C, Cugnata F, Calzoni E, Crooks GM, Notarangelo LD, Genovese P, Naldini L, Villa A. | 02/14/2024 |
| Rag1 Deficiency Impairs Arteriogenesis in Mice. | Rag1 Deficiency Impairs Arteriogenesis in Mice.
Kumaraswami K, Arnholdt C, Deindl E, Lasch M., Free PMC Article | 08/30/2023 |
| Spi-C and PU.1 Counterregulate Rag1 and Igkappa Transcription to Effect Vkappa-Jkappa Recombination in Small Pre-B Cells. | Spi-C and PU.1 Counterregulate Rag1 and Igκ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells.
Xu LS, Zhu JT, Raczkowski HL, Batista CR, DeKoter RP. | 06/26/2023 |
| The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRbeta and TCRalpha Genes and Influences Development of alphabeta T Cell Lineages. | The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages.
Burn TN, Miot C, Gordon SM, Culberson EJ, Diamond T, Kreiger PA, Hayer KE, Bhattacharyya A, Jones JM, Bassing CH, Behrens EM., Free PMC Article | 10/8/2022 |
| Zika virus vertical transmission in interferon receptor1-antagonized Rag1(-/-) mice results in postnatal brain abnormalities and clinical disease. | Zika virus vertical transmission in interferon receptor1-antagonized Rag1(-/-) mice results in postnatal brain abnormalities and clinical disease.
Winkler CW, Clancy CS, Rosenke R, Peterson KE., Free PMC Article | 04/23/2022 |
| MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development. | MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development.
Kumari R, Roy U, Desai S, Nilavar NM, Van Nieuwenhuijze A, Paranjape A, Radha G, Bawa P, Srivastava M, Nambiar M, Balaji KN, Liston A, Choudhary B, Raghavan SC. | 02/12/2022 |
| Healing of sub-critical femoral osteotomies in mice is unaffected by tacrolimus and deletion of recombination activating gene 1. | Healing of sub-critical femoral osteotomies in mice is unaffected by tacrolimus and deletion of recombination activating gene 1.
Liu TY, Bartnikowski M, Wu AC, Veitch M, Sokolowski KA, Millard SM, Pettit AR, Glatt V, Evans CH, Wells JW. | 01/15/2022 |
| The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. | The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination.
Beilinson HA, Glynn RA, Yadavalli AD, Xiao J, Corbett E, Saribasak H, Arya R, Miot C, Bhattacharyya A, Jones JM, Pongubala JMR, Bassing CH, Schatz DG., Free PMC Article | 12/4/2021 |
| ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-beta1. | ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-β1.
Umeda M, Yoshida N, Hisada R, Burbano C, Orite SYK, Kono M, Kyttaris VC, Krishfield S, Owen CA, Tsokos GC., Free PMC Article | 12/4/2021 |
| The effect of CRISPR constructs microinjection on the expression of developmental genes in Rag1 knocked-out mice embryo. | The effect of CRISPR constructs microinjection on the expression of developmental genes in Rag1 knocked-out mice embryo.
Salimi M, Shirazi A, Sineh Sepehr K, Norouzian M, Ebrahimi V, Mehravar M, Majidi M, Mehrazar MM., Free PMC Article | 10/16/2021 |
| Bone Marrow-Derived Dendritic Cell Cultures from RAG(-/-) Mice Include IFN-gamma-Producing NK Cells. | Bone Marrow-Derived Dendritic Cell Cultures from RAG(-/-) Mice Include IFN-γ-Producing NK Cells.
Abdi K, Thomas LM, Laky K, Abshari M, Matzinger P, Long EO., Free PMC Article | 10/16/2021 |
| Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk. | Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk.
Parrish PCR, Liu D, Knutsen RH, Billington CJ, Mecham RP, Fu YP, Kozel BA., Free PMC Article | 08/28/2021 |
| T and B Lymphocyte Deficiency in Rag1-/- Mice Reduces Retinal Ganglion Cell Loss in Experimental Glaucoma. | T and B Lymphocyte Deficiency in Rag1-/- Mice Reduces Retinal Ganglion Cell Loss in Experimental Glaucoma.
Gramlich OW, Godwin CR, Heuss ND, Gregerson DS, Kuehn MH., Free PMC Article | 05/15/2021 |
| Loop extrusion mediates physiological Igh locus contraction for RAG scanning. | Loop extrusion mediates physiological Igh locus contraction for RAG scanning.
Dai HQ, Hu H, Lou J, Ye AY, Ba Z, Zhang X, Zhang Y, Zhao L, Yoon HS, Chapdelaine-Williams AM, Kyritsis N, Chen H, Johnson K, Lin S, Conte A, Casellas R, Lee CS, Alt FW., Free PMC Article | 03/13/2021 |
| Mutation of the RAG1 nucleolar localization motif boosts recombination while removal of the first 215 amino acids of RAG1 reduces recombination activity. | Nucleolar localization of RAG1 modulates V(D)J recombination activity.
Brecht RM, Liu CC, Beilinson HA, Khitun A, Slavoff SA, Schatz DG., Free PMC Article | 07/18/2020 |
| The structure of a DNA-strand transfer complex of mouse RAG1-RAG2 at 3.1-A resolution is determined. | How mouse RAG recombinase avoids DNA transposition.
Chen X, Cui Y, Wang H, Zhou ZH, Gellert M, Yang W., Free PMC Article | 04/25/2020 |
| In analyzing site-specific DNA cleavage by the mouse RAG1-RAG2 recombinase, which initiates V(D)J recombination, the study finds that the active site is reconfigured for the two consecutive reactions and the DNA double helix adopts drastically different structures. | Cutting antiparallel DNA strands in a single active site.
Chen X, Cui Y, Best RB, Wang H, Zhou ZH, Yang W, Gellert M., Free PMC Article | 04/25/2020 |
| A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination. | A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination.
Thwaites DT, Carter C, Lawless D, Savic S, Boyes JM., Free PMC Article | 10/26/2019 |
| The basis for RAG1 turnover and provide evidence that the CRL4(VprBP(DCAF1)) complex functions to maintain physiological levels of V(D)J recombination. | VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation.
Schabla NM, Perry GA, Palmer VL, Swanson PC., Free PMC Article | 06/22/2019 |
| Determined crystal and cryo-EM structures of RAG1/2 with DNA in the pre-reaction and hairpin-forming complexes up to 2.75 A resolution in V(D)J recombination. | Cracking the DNA Code for V(D)J Recombination.
Kim MS, Chuenchor W, Chen X, Cui Y, Zhang X, Zhou ZH, Gellert M, Yang W., Free PMC Article | 02/9/2019 |
| this study determined that the depletion of uterine innate lymphoid cells in Rag1-/- mice resulted in impaired uterine spiral artery remodeling and reduced fetal viability | Molecular signature and functional analysis of uterine ILCs in mouse pregnancy.
Li M, Gao Y, Yong L, Huang D, Shen J, Liu M, Ren C, Hou X. | 05/26/2018 |
| Describe spontaneous S. xylosus infection in a genetically modified murine model. S. xylosus infection in Rag1-/-Tpl2-/- mice correlated with disseminated bacteria and elevated numbers of circulating monocytes. | Severe Dermatitis Associated with Spontaneous Staphylococcus xylosus Infection in Rag(-/-)Tpl2(-/-) Mice.
Acuff NV, LaGatta M, Nagy T, Watford WT., Free PMC Article | 05/12/2018 |
| This study demonstrated that the lymphocyte-deficient Rag1 animals demonstrated a significantly lower rate of aneurysm formation and rupture. | Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells.
Sawyer DM, Pace LA, Pascale CL, Kutchin AC, O'Neill BE, Starke RM, Dumont AS., Free PMC Article | 09/30/2017 |
| This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte development to prevent mistimed dsDNA breaks and their deleterious consequences. | Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation.
Timblin GA, Xie L, Tjian R, Schlissel MS., Free PMC Article | 09/16/2017 |