| Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis. | Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis.
Zhu LY, Yuan JB, Zhang L, He CX, Lin X, Xu B, Jin GH. | 11/19/2022 |
| Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses. | Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses.
Choi SY, Ahn YR, Lee EB, Yu MJ, Lee JR., Free PMC Article | 04/23/2022 |
| RasGRF1 has no effect on self administration for cocaine. | The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.
Bernardi RE, Olevska A, Morella I, Fasano S, Santos E, Brambilla R, Spanagel R., Free PMC Article | 06/27/2020 |
| p190RhoGEF may play a role in the stage of plasma cell differentiation during T-cell-dependent humoral immune responses. | Over-expression of p190RhoGEF enhances B-cell activation and germinal center formation in T-cell-dependent humoral immune responses.
Jeong JH, Ha YJ, Choi SY, Kim JH, Yun Y, Lee JR. | 04/25/2020 |
| The deletion of RasGRF1 attenuated myocardial fibrosis and improved cardiac function in diabetic mice through inhibiting inflammation and oxidative stress. | Deletion of RasGRF1 Attenuated Interstitial Fibrosis in Streptozotocin-Induced Diabetic Cardiomyopathy in Mice through Affecting Inflammation and Oxidative Stress.
Tsai TH, Lin CJ, Chua S, Chung SY, Chen SM, Lee CH, Hang CL., Free PMC Article | 01/19/2019 |
| hypermethylation of RASgrf1 after kainate induced status epilepticus could be reversed with corresponding changes of RASgrf1 expression | RASgrf1, a Potential Methylatic Mediator of Anti-epileptogenesis?
Bao Y, Chen X, Wang L, Zhou J, Fu X, Wang X, Xiao Z. | 01/19/2019 |
| These findings demonstrate that RASgrf1 is closely associated with epilepsy via the aberrant methylation of RASgrf1, and regulating the methylation status of relevant genes might be an intriguing topic in future research on epilepsy. | Association of RASgrf1 methylation with epileptic seizures.
Chen X, Peng X, Wang L, Fu X, Zhou JX, Zhu B, Luo J, Wang X, Xiao Z., Free PMC Article | 04/14/2018 |
| Novel mercaptoacetamide-based class II histone deacetylase inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK, and that W2 requires RasGRF1 and ERK signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK-dependent signaling pathway | A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Increases Dendritic Spine Density via RasGRF1/ERK Pathway.
Song JM, Sung YM, Nam JH, Yoon H, Chung A, Moffat E, Jung M, Pak DT, Kim J, Hoe HS. | 12/24/2016 |
| Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice. | RasGRF1 regulates the hypothalamic-pituitary-adrenal axis specifically in early-adolescent female mice.
Uzturk BG, Jin SX, Rubin B, Bartolome C, Feig LA., Free PMC Article | 12/5/2015 |
| VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. | Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.
DiBattista AM, Dumanis SB, Song JM, Bu G, Weeber E, Rebeck GW, Hoe HS., Free PMC Article | 09/5/2015 |
| Study suggests a complex role of ERK-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals | Derangement of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and extracellular signal-regulated kinase (ERK) dependent striatal plasticity in L-DOPA-induced dyskinesia.
Cerovic M, Bagetta V, Pendolino V, Ghiglieri V, Fasano S, Morella I, Hardingham N, Heuer A, Papale A, Marchisella F, Giampà C, Calabresi P, Picconi B, Brambilla R. | 08/15/2015 |
| RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses. | Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells.
Manyes L, Arribas M, Gomez C, Calzada N, Fernandez-Medarde A, Santos E., Free PMC Article | 07/25/2015 |
| CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. | CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.
Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu YM, Yang L, Guan JH, Xu GT, Lin X., Free PMC Article | 02/21/2015 |
| GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts. | Age-dependent role for Ras-GRF1 in the late stages of adult neurogenesis in the dentate gyrus.
Darcy MJ, Trouche S, Jin SX, Feig LA., Free PMC Article | 10/11/2014 |
| Data indicate that contextual discrimination involves term potentiation (LTP) promoted by calcium-permeable AMPA-type glutamate receptors, RAS-GRF1 and p38 MAP kinase. | Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP).
Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA., Free PMC Article | 11/16/2013 |
| Ras-GRF1 and -GRF2 may act as adaptors that bind PLCgamma1 and restrict Ca2+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 induction of the Ras-->ERK pathway and MMP-3 expression | Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
Wang Q, Siminovitch KA, Downey GP, McCulloch CA. | 03/9/2013 |
| identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 target gene in beta cells | Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1.
Hoffmann A, Spengler D., Free PMC Article | 09/8/2012 |
| Present RasGRF1-derived peptides displaying both in vitro and in vivo Ras inhibitory properties. | Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells.
Sacco E, Metalli D, Spinelli M, Manzoni R, Samalikova M, Grandori R, Morrione A, Traversa S, Alberghina L, Vanoni M. | 07/14/2012 |
| p190A is required in both the epithelial and stromal compartments for ductal outgrowth and it may play a role in mammary epithelial cell differentiation | P190A RhoGAP is required for mammary gland development.
Heckman-Stoddard BM, Vargo-Gogola T, Herrick MP, Visbal AP, Lewis MT, Settleman J, Rosen JM., Free PMC Article | 01/7/2012 |
| these results indicate that Rasgrf1 expression from the wild-type paternal allele contributes to learning and memory in neonatal mice. | Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory.
Drake NM, DeVito LM, Cleland TA, Soloway PD., Free PMC Article | 10/8/2011 |
| Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. | RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P. | 09/10/2011 |
| role of RASGRF1 in aging, lifespan and metabolic parameters were analyzed in aged RasGrf1(-/-) mice. We observed that mice deficient for RasGrf1(-/-) display an increase in average and most importantly, in maximal lifespan (20% higher than controls). | RasGrf1 deficiency delays aging in mice.
Borrás C, Monleón D, López-Grueso R, Gambini J, Orlando L, Pallardó FV, Santos E, Viña J, Font de Mora J., Free PMC Article | 08/13/2011 |
| study found components of the piRNA pathway are required for de novo methylation of the differentially methylated region of imprinted Rasgrf1 locus; propose a model in which piRNAs and a target RNA direct sequence-specific methylation of Rasgrf | Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.
Watanabe T, Tomizawa S, Mitsuya K, Totoki Y, Yamamoto Y, Kuramochi-Miyagawa S, Iida N, Hoki Y, Murphy PJ, Toyoda A, Gotoh K, Hiura H, Arima T, Fujiyama A, Sado T, Shibata T, Nakano T, Lin H, Ichiyanagi K, Soloway PD, Sasaki H., Free PMC Article | 05/28/2011 |
| These data reveal the central role of Ras-GRF1 in governing striatal adaptations to dopamine replacement therapy and validate a viable treatment for LID based on intracellular signaling modulation. | Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.
Fasano S, Bezard E, D'Antoni A, Francardo V, Indrigo M, Qin L, Doveró S, Cerovic M, Cenci MA, Brambilla R., Free PMC Article | 05/14/2011 |
| the evidence points towards the involvement of Rasgrf1 in the regulation of longevity, hypothetically through a mechanism similar to that observed in other long-lived mice of low GH/IGF-1 signaling causing a low body weight and life-extension | Paternal genome effects on aging: evidence for a role of Rasgrf1 in longevity determination?
de Magalhães JP. | 05/14/2011 |