| RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells. | RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
Shepherd A, Feinstein L, Sabel S, Rastelli D, Mezhibovsky E, Matthews L, Muppirala A, Robinson A, Sharma KR, ElSeht A, Zeve D, Breault DT, Gershon MD, Rao M., | 02/26/2024 |
| Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development. | Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development.
Vincent E, Chatterjee S, Cannon GH, Auer D, Ross H, Chakravarti A, Goff LA., Free PMC Article | 08/19/2023 |
| ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model. | ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model.
Zhao Z, Dai X, Jiang G, Lin F., | 06/13/2023 |
| A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism. | A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.
Sunardi M, Ito K, Sato Y, Uesaka T, Iwasaki M, Enomoto H., Free PMC Article | 05/30/2023 |
| The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET. | The kinase PLK1 promotes the development of Kras/Tp53-mutant lung adenocarcinoma through transcriptional activation of the receptor RET.
Kong Y, Allison DB, Zhang Q, He D, Li Y, Mao F, Li C, Li Z, Zhang Y, Wang J, Wang C, Brainson CF, Liu X., Free PMC Article | 10/8/2022 |
| Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons. | Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.
Rhymes ER, Tosolini AP, Fellows AD, Mahy W, McDonald NQ, Schiavo G., Free PMC Article | 07/16/2022 |
| GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma. | GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma.
Dong Y, Huang Y, Fan C, Wang L, Zhang R, Li W, Guo Z, Wang D, Zheng Z., Free PMC Article | 10/16/2021 |
| Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome. | Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome.
Ohgami N, Iizuka A, Hirai H, Yajima I, Iida M, Shimada A, Tsuzuki T, Jijiwa M, Asai N, Takahashi M, Kato M., Free PMC Article | 09/11/2021 |
| Hair graying with aging in mice carrying oncogenic RET. | Hair graying with aging in mice carrying oncogenic RET.
Iida M, Tazaki A, Yajima I, Ohgami N, Taguchi N, Goto Y, Kumasaka MY, Prévost-Blondel A, Kono M, Akiyama M, Takahashi M, Kato M., Free PMC Article | 08/28/2021 |
| RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas. | RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas.
Nagy N, Guyer RA, Hotta R, Zhang D, Newgreen DF, Halasy V, Kovacs T, Goldstein AM., Free PMC Article | 12/26/2020 |
| Point mutagenesis in mouse reveals contrasting pathogenetic effects between MEN2B- and Hirschsprung disease-associated missense mutations of the RET gene. | Point mutagenesis in mouse reveals contrasting pathogenetic effects between MEN2B- and Hirschsprung disease-associated missense mutations of the RET gene.
Nakatani T, Iwasaki M, Yamamichi A, Yoshioka Y, Uesaka T, Bitoh Y, Maeda K, Fukumoto T, Takemoto T, Enomoto H. | 12/12/2020 |
| Acute stress disrupts intestinal homeostasis via GDNF-RET. | Acute stress disrupts intestinal homeostasis via GDNF-RET.
Lin L, Feng B, Zhou R, Liu Y, Li L, Wang K, Yu Y, Liu C, Long X, Gu X, Li B, Wang X, Yang X, Cong Y, Zuo X, Li Y., Free PMC Article | 10/31/2020 |
| RET can be an essential co-driver of pancreatic tumorigenesis in conjugation with KRAS activity. | RET, a targetable driver of pancreatic adenocarcinoma.
Amit M, Na'ara S, Fridman E, Vladovski E, Wasserman T, Milman N, Gil Z. | 10/12/2019 |
| Removal of Ret disrupts nerve growth factor-mediated TrkA ubiquitination, leading to increased cell surface levels of TrkA, thereby potentiating survival signaling. Ret deletion significantly impairs p75 regulated intramembrane proteolysis cleavage, leading to reduced activation of downstream apoptotic effectors. | Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons.
Donnelly CR, Gabreski NA, Suh EB, Chowdhury M, Pierchala BA., Free PMC Article | 09/21/2019 |
| Immunohistochemistry and random sparse recombination coupled with histochemical AP staining provided an in-depth characterization of retinal ganglion cells (RGCs), horizontal cells (HCs) and amacrine cells (ACs) expressing RET. Ret is expressed in at least three distinct types of ACs, and ten types of RGCs. Ret expression overlaps with Brn3a in 4 RGC types, with Brn3b in 5 RGC types, and with Brn3c in one RGC type. | Characterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret.
Parmhans N, Sajgo S, Niu J, Luo W, Badea TC., Free PMC Article | 03/16/2019 |
| An oncogenic role of non-mutated Ret in the mammary gland. | Chronic expression of wild-type Ret receptor in the mammary gland induces luminal tumors that are sensitive to Ret inhibition.
Gattelli A, García Solá ME, Roloff TC, Cardiff RD, Kordon EC, Chodosh LA, Hynes NE. | 03/2/2019 |
| p75 is required for the development of the nonpeptidergic nociceptor lineage by fine-tuning Ret-mediated trophic support. | p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling.
Chen Z, Donnelly CR, Dominguez B, Harada Y, Lin W, Halim AS, Bengoechea TG, Pierchala BA, Lee KF., Free PMC Article | 06/16/2018 |
| 7-DHC efficiently supports Ret signaling in vitro. | 7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome.
Gou-Fàbregas M, Macià A, Anerillas C, Vaquero M, Jové M, Jain S, Ribera J, Encinas M., Free PMC Article | 05/12/2018 |
| Results showed that Mn-mediated age-related hearing loss involved a decreased expression and phosphorylation levels of c-Ret in spiral ganglion neurons. | Manganese-mediated acceleration of age-related hearing loss in mice.
Ohgami N, Yajima I, Iida M, Li X, Oshino R, Kumasaka MY, Kato M., Free PMC Article | 05/12/2018 |
| Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRalpha1 or RET Impairs Normal Cerebellar Motor Learning | Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning.
Sergaki MC, López-Ramos JC, Stagkourakis S, Gruart A, Broberger C, Delgado-García JM, Ibáñez CF., Free PMC Article | 03/10/2018 |
| Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity. | NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.
Qiu X, Wei R, Li Y, Zhu Q, Xiong C, Chen Y, Zhang Y, Lu K, He F, Zhang L., Free PMC Article | 12/30/2017 |
| The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase. | GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.
Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis AK, Sawa Y, Sasaki H, Ozono K, Suzuki K, Yashiro K., Free PMC Article | 11/25/2017 |
| Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. | Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.
Drinkut A, Tillack K, Meka DP, Schulz JB, Kügler S, Kramer ER., Free PMC Article | 10/28/2017 |
| Mechanistically, Ret is engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases. | Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia.
Perea D, Guiu J, Hudry B, Konstantinidou C, Milona A, Hadjieconomou D, Carroll T, Hoyer N, Natarajan D, Kallijärvi J, Walker JA, Soba P, Thapar N, Burns AJ, Jensen KB, Miguel-Aliaga I., Free PMC Article | 10/21/2017 |
| Authors did not find evidence for genetic interaction between Ret and Sema3d affecting survival, presence of myenteric plexus or intestine transcriptome. | Testing the Ret and Sema3d genetic interaction in mouse enteric nervous system development.
Kapoor A, Auer DR, Lee D, Chatterjee S, Chakravarti A., Free PMC Article | 10/14/2017 |