| A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player. | A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player.
Schaid TR Jr, LaCroix I, Hansen KC, D'Alessandro A, Moore EE, Sauaia A, Dzieciatkowska M, DeBot M, Cralley AL, Thielen O, Hallas W, Erickson C, Mitra S, Banerjee A, Jones K, Silliman CC, Cohen MJ., Free PMC Article | 02/27/2023 |
| SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway. | SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway.
Wang H, Hua J, Chen S, Chen Y., Free PMC Article | 04/23/2022 |
| A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and beta-Cell Function in Egyptian Type 2 Diabetic Patients. | A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and β-Cell Function in Egyptian Type 2 Diabetic Patients.
Kassem DH, Adel A, Sayed GH, Kamal MM., Free PMC Article | 06/5/2021 |
| A striking decrease in the expression of SERPINB1 gene, which encodes a critical component of neutrophil survival, was detected in Cohen syndrome neutrophils. | Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.
Duplomb L, Rivière J, Jego G, Da Costa R, Hammann A, Racine J, Schmitt A, Droin N, Capron C, Gougerot-Pocidalo MA, Dubrez L, Aral B, Lafon A, Edery P, Ghoumid J, Blair E, El Chehadeh-Djebbar S, Carmignac V, Thevenon J, Guy J, Girodon F, Bastie JN, Delva L, Faivre L, Thauvin-Robinet C, Solary E. | 06/27/2020 |
| Analysis of The Cancer Genome Atlas and pyrosequencing demonstrate hypermethylation of the SERPINB1 promoter in prostate cancer compared with normal tissue, and the extent of promoter methylation negatively correlates with SERPINB1 mRNA expression. | Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.
Lerman I, Ma X, Seger C, Maolake A, Garcia-Hernandez ML, Rangel-Moreno J, Ackerman J, Nastiuk KL, Susiarjo M, Hammes SR., Free PMC Article | 01/11/2020 |
| This study demonstrated that female-specific role for SERPINB1 in amyloidosis. | Sex-specific genetic predictors of Alzheimer's disease biomarkers.
Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ., Free PMC Article | 10/12/2019 |
| Results indicate that serpin family B member 1 (SERPINB1) acts as a vital gatekeeper of inflammation by restraining neutrophil serine proteases and inflammatory caspases in a genetically and functionally separable manner. | SERPINB1-mediated checkpoint of inflammatory caspase activation.
Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU., Free PMC Article | 05/4/2019 |
| The expression of SERPINB1 was approximately 2-fold higher in apical periodontitis. SERPINB1 expression was noted in neutrophils and epithelial cells. | Proteomic Profiling and Differential Messenger RNA Expression Correlate HSP27 and Serpin Family B Member 1 to Apical Periodontitis Outcomes.
Cavalla F, Biguetti C, Jain S, Johnson C, Letra A, Garlet GP, Silva RM. | 06/30/2018 |
| SERPINB1 decreased inflammation, ameliorated oxidative stress in the lung, and attenuated acute lung injury in rats with orthotopic autologous liver transplantation by activating HO-1 and it does so through STAT3 | SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction.
Yao W, Li H, Luo G, Li X, Chen C, Yuan D, Chi X, Xia Z, Hei Z. | 04/14/2018 |
| a relatively low Serpinb1a protein threshold in neutrophils that is required for sustained survival | Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.
Burgener SS, Baumann M, Basilico P, Remold-O'Donnell E, Touw IP, Benarafa C. | 07/15/2017 |
| SERPINB1 expression is significantly upregulated in human masticatory mucosa during wound healing | Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN. | 03/22/2017 |
| Data show that high serpin B1 protein (SERPINB1) gene expression was associated with favorable tumor response and prolonged survival under cisplatin-based chemotherapy. | SERPINB1 expression is predictive for sensitivity and outcome of cisplatin-based chemotherapy in melanoma.
Willmes C, Kumar R, Becker JC, Fried I, Rachakonda PS, Poppe LM, Hesbacher S, Schadendorf D, Sucker A, Schrama D, Ugurel S., Free PMC Article | 01/28/2017 |
| Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1, SERPINB4 and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors. | Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors.
van Kempen PM, Noorlag R, Swartz JE, Bovenschen N, Braunius WW, Vermeulen JF, Van Cann EM, Grolman W, Willems SM., Free PMC Article | 09/10/2016 |
| Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC-I and CD1d expression. Intriguingly, expression of SERPINB9, SERPINB1, and SERPINB4 is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors | Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System Differentially Express Granzyme Inhibitors.
Vermeulen JF, van Hecke W, Spliet WG, Villacorta Hidalgo J, Fisch P, Broekhuizen R, Bovenschen N., Free PMC Article | 08/6/2016 |
| is not expressed in neutrophils of both sulfur mustard-exposed and chronic obstructive pulmonary disease patients | Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients.
Shahriary A, Mehrani H, Ghanei M, Parvin S. | 12/5/2015 |
| Data suggest that serine protease inhibitor (SERPIN) B1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of matrix metalloproteinase-2 and the activation of focal adhesion kinase. | Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells.
Huasong G, Zongmei D, Jianfeng H, Xiaojun Q, Jun G, Sun G, Donglin W, Jianhong Z. | 12/5/2015 |
| Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma. | Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma.
Cui X, Liu Y, Wan C, Lu C, Cai J, He S, Ni T, Zhu J, Wei L, Zhang Y, Qian H. | 09/13/2014 |
| Apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death. | Apoptosis-inducing factor (AIF) and leukocyte elastase inhibitor/L-DNase II (LEI/LDNaseII), can interact to conduct caspase-independent cell death.
Leprêtre C, Tchakarska G, Blibech H, Lebon C, Torriglia A. | 03/22/2014 |
| Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition. | Identification of SERPINB1 as a physiological inhibitor of human granzyme H.
Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. | 03/30/2013 |
| In the resting state during human neutrophil extracellar trap generation, SerpinB1 is exclusively in the cytoplasm, consistent with the current understanding of clade B serpins, and it may migrate and regulate events in the cell nucleus. | A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation.
Farley K, Stolley JM, Zhao P, Cooley J, Remold-O'Donnell E., Free PMC Article | 01/12/2013 |
| These results suggest that serpin B1 may be a novel marker of active ulcerative colitis and may play an important role in the pathogenesis of inflammatory bowel disease. | Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis.
Uchiyama K, Naito Y, Takagi T, Mizushima K, Hirai Y, Hayashi N, Harusato A, Inoue K, Fukumoto K, Yamada S, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T. | 07/21/2012 |
| serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses. | SerpinB1 protects the mature neutrophil reserve in the bone marrow.
Benarafa C, LeCuyer TE, Baumann M, Stolley JM, Cremona TP, Remold-O'Donnell E., Free PMC Article | 09/10/2011 |
| The findings define an innate role for SerpinB1 in cystic fibrosis airways. | SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition.
Cooley J, Sontag MK, Accurso FJ, Remold-O'Donnell E., Free PMC Article | 09/3/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCommon polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.
Wang Y, Fu W, Xie F, Wang Y, Chu X, Wang H, Shen M, Wang Y, Wang Y, Sun W, Lei R, Yang L, Wu H, Foo J, Liu J, Jin L, Huang W. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T. | 06/30/2010 |
| M/NEI is a dual specificity inhibitor with two adjacent reactive sites that support rapid efficient inhibitory reactions with cellular proteases, including the three neutrophil granule proteases. | The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.
Cooley J, Takayama TK, Shapiro SD, Schechter NM, Remold-O'Donnell E. | 01/21/2010 |