| PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases. | PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases.
Barlow-Busch I, Shaw AL, Burke JE. | 08/10/2023 |
| PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions. | PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions.
Caux M, Mansour R, Xuereb JM, Chicanne G, Viaud J, Vauclard A, Boal F, Payrastre B, Tronchère H, Severin S. | 08/6/2022 |
| Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer. | Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer.
Qiao Y, Choi JE, Tien JC, Simko SA, Rajendiran T, Vo JN, Delekta AD, Wang L, Xiao L, Hodge NB, Desai P, Mendoza S, Juckette K, Xu A, Soni T, Su F, Wang R, Cao X, Yu J, Kryczek I, Wang XM, Wang X, Siddiqui J, Wang Z, Bernard A, Fernandez-Salas E, Navone NM, Ellison SJ, Ding K, Eskelinen EL, Heath EI, Klionsky DJ, Zou W, Chinnaiyan AM., Free PMC Article | 04/30/2022 |
| AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation. | AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation.
Karabiyik C, Rubinsztein DC., Free PMC Article | 03/26/2022 |
| Disruption of PIKFYVE causes congenital cataract in human and zebrafish. | Disruption of PIKFYVE causes congenital cataract in human and zebrafish.
Mei S, Wu Y, Wang Y, Cui Y, Zhang M, Zhang T, Huang X, Yu S, Yu T, Zhao J., Free PMC Article | 03/5/2022 |
| Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner. | Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
Karabiyik C, Vicinanza M, Son SM, Rubinsztein DC. | 10/23/2021 |
| Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2. | Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
Dovat E, Song C, Hu T, Rahman MA, Dhanyamraju PK, Klink M, Bogush D, Soliman M, Kane S, McGrath M, Ding Y, Desai D, Sharma A, Gowda C., Free PMC Article | 04/17/2021 |
| PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux and a massive enlargement of lysosomes. | Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.
Choy CH, Saffi G, Gray MA, Wallace C, Dayam RM, Ou ZA, Lenk G, Puertollano R, Watkins SC, Botelho RJ., Free PMC Article | 11/2/2019 |
| this study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase | The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
Dayam RM, Sun CX, Choy CH, Mancuso G, Glogauer M, Botelho RJ. | 10/14/2017 |
| in PC-3 cells inhibition of PIKfyve by apilimod or depletion by siRNA increased the secretion of the exosomal fraction. | PIKfyve inhibition increases exosome release and induces secretory autophagy.
Hessvik NP, Øverbye A, Brech A, Torgersen ML, Jakobsen IS, Sandvig K, Llorente A. | 08/5/2017 |
| Here we identify the lipid kinase PIKfyve as a regulator of an alternative pathway that distributes engulfed contents in support of intracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis. We find that PIKfyve regulates vacuole size in part through its downstream effector, the cationic transporter TRPML1 | PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.
Krishna S, Palm W, Lee Y, Yang W, Bandyopadhyay U, Xu H, Florey O, Thompson CB, Overholtzer M., Free PMC Article | 06/24/2017 |
| A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity. | A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity.
Guscott B, Balklava Z, Safrany ST, Wassmer T., Free PMC Article | 12/17/2016 |
| A novel heterozygous frameshift mutation (c.3151dupA) and a copy number variations in PIKFYVE gene have been found in two unrelated Fleck corneal dystrophy patients. | Identification of novel PIKFYVE gene mutations associated with Fleck corneal dystrophy.
Gee JA, Frausto RF, Chung DW, Tangmonkongvoragul C, Le DJ, Wang C, Han J, Aldave AJ., Free PMC Article | 06/28/2016 |
| The PIKfyve complex is required for APP trafficking, suggesting a feedback loop in which APP, by binding to and stimulating phosphatidylinositol-3,5-bisphosphate vesicle formation may control its own trafficking. | APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.
Currinn H, Guscott B, Balklava Z, Rothnie A, Wassmer T., Free PMC Article | 05/28/2016 |
| APP functionally cooperates with PIKfyve in vivo. This regulation is required for maintaining endosomal and neuronal function. | The Amyloid Precursor Protein Controls PIKfyve Function.
Balklava Z, Niehage C, Currinn H, Mellor L, Guscott B, Poulin G, Hoflack B, Wassmer T., Free PMC Article | 04/23/2016 |
| data identify a novel role of the ArPIKfyve-Sac3 complex in the mechanisms controlling aggregate formation of Sph1 and suggest that Sac3 protein deficiency or overproduction may facilitate aggregation of aggregation-prone proteins | The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.
Ikonomov OC, Sbrissa D, Compton LM, Kumar R, Tisdale EJ, Chen X, Shisheva A., Free PMC Article | 04/2/2016 |
| Data suggest PIKFYVE, MTMR3 (myotubularin related protein 3) and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma. | PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J. | 09/27/2014 |
| Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3, which is necessary and sufficient for suppression of type I IFN expression. | PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3.
Cai X, Xu Y, Kim YM, Loureiro J, Huang Q. | 06/14/2014 |
| Data indicate that AKT promotes EGFR recycling by phosphorylating and activating PIKfyve. | AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J., Free PMC Article | 01/18/2014 |
| the present observations show that PKB in conjunction with PIKfyve activates Kir2.1 channels. | Up-regulation of the inwardly rectifying K⁺ channel Kir2.1 (KCNJ2) by protein kinase B (PKB/Akt) and PIKfyve.
Munoz C, Almilaji A, Setiawan I, Föller M, Lang F. | 08/31/2013 |
| Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. | Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration.
Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J., Free PMC Article | 06/8/2013 |
| PIP5Kalpha promotes TLR4-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP to the plasma membrane | Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location.
Nguyen TT, Kim YM, Kim TD, Le OT, Kim JJ, Kang HC, Hasegawa H, Kanaho Y, Jou I, Lee SY., Free PMC Article | 04/27/2013 |
| The results provide the first experimental evidence that the principal pathway for PtdIns5P intracellular production is through PIKfyve. | Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
Sbrissa D, Ikonomov OC, Filios C, Delvecchio K, Shisheva A., Free PMC Article | 11/17/2012 |
| A novel c.3060-3063 delCCTT (p.P968Vfs23) mutation in the PIKFYVE gene has been described in a five generation Greek family, which segregated with the fleck corneal dystrophy. | A novel PIKFYVE mutation in fleck corneal dystrophy.
Kotoulas A, Kokotas H, Kopsidas K, Droutsas K, Grigoriadou M, Bajrami H, Schorderet DF, Petersen MB., Free PMC Article | 03/3/2012 |
| The recent advances in Arf6/PIP5K signaling and its linkage to cellular functions, are reviewed. | Regulation of PIP5K activity by Arf6 and its physiological significance.
Funakoshi Y, Hasegawa H, Kanaho Y. | 03/5/2011 |