| Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase. | Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.
Tabassum Z, Tseng JH, Isemann C, Tian X, Chen Y, Herring LE, Cohen TJ., Free PMC Article | 07/2/2022 |
| MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1alpha and p53 pathways. | MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1α and p53 pathways.
Ponnusamy L, Natarajan SR, Manoharan R. | 05/14/2022 |
| MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKalpha1/mTOR/HIF-1alpha signaling pathway. | MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway.
Natarajan SR, Ponnusamy L, Manoharan R. | 04/16/2022 |
| Long non-coding RNA ABHD11-AS1 facilitates the progression of cervical cancer by competitively binding to miR-330-5p and upregulating MARK2. | Long non-coding RNA ABHD11-AS1 facilitates the progression of cervical cancer by competitively binding to miR-330-5p and upregulating MARK2.
Hou S, Zhang X, Yang J. | 01/15/2022 |
| The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80. | The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80.
Mashukova A, Forteza R, Shah VN, Salas PJ., Free PMC Article | 09/18/2021 |
| MARK2 phosphorylates eIF2alpha in response to proteotoxic stress. | MARK2 phosphorylates eIF2α in response to proteotoxic stress.
Lu YN, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, He L, Wang J., Free PMC Article | 07/31/2021 |
| Study shows that MARK2 is required to recentre spindles that are off-centred following actin disassembly, showing the close functional relationship between MARK2 and the actin network. These results suggest that, during both interphase and mitosis, MARK2 localizes at specialized membrane subdomains and coordinates actin and microtubule cytoskeletal changes, thus enabling normal cell division. | MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassembly.
Hart M, Zulkipli I, Shrestha RL, Dang D, Conti D, Gul P, Kujawiak I, Draviam VM., Free PMC Article | 05/2/2020 |
| Par1b-inhibition by CagA contributes to DNA Double Strand Breaks in H. pylori infected human primary gastric epithelial cells. | Inhibition of polarity-regulating kinase PAR1b contributes to Helicobacter pylori inflicted DNA Double Strand Breaks in gastric cells.
Zamperone A, Cohen D, Stein M, Viard C, Müsch A., Free PMC Article | 03/28/2020 |
| Clustering of the CD44 extracellular domain by high-molecular-weight hyaluronan leads to recruitment of the polarity-regulating kinase PAR1b by the CD44 intracellular domain, which results in disruption of the Hippo signaling-inhibitory PAR1b-MST complex. | High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b.
Ooki T, Murata-Kamiya N, Takahashi-Kanemitsu A, Wu W, Hatakeyama M. | 01/11/2020 |
| The authors uncovered a novel role for MARK2 in maintaining the mitotic spindle at the cell's geometric center. | Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle-centering mechanism.
Zulkipli I, Clark J, Hart M, Shrestha RL, Gul P, Dang D, Kasichiwin T, Kujawiak I, Sastry N, Draviam VM., Free PMC Article | 09/21/2019 |
| In cell-based assays, Mark2 depletion indeed reduces Dvl gene expression and interrupts neural stem cell (NSCs) growth and differentiation, which are likely to be mediated through a decrease in class IIa HDAC phosphorylation and reduced H3K4ac and H3K27ac occupancies at the Dvl1/2 promoters. | MARK2/Par1b Insufficiency Attenuates DVL Gene Transcription via Histone Deacetylation in Lumbosacral Spina Bifida.
Chen S, Zhang Q, Bai B, Ouyang S, Bao Y, Li H, Zhang T. | 07/14/2018 |
| HIV-1 did not stimulate widespread FEZ1 phosphorylation but, instead, bound microtubule (MT) affinity-regulating kinase 2 (MARK2) to stimulate FEZ1 phosphorylation on viral cores. | Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating.
Malikov V, Naghavi MH., Free PMC Article | 06/9/2018 |
| Low expression of Mark2 is associated with uterine cervical neoplasms. | MARK2 inhibits the growth of HeLa cells through AMPK and reverses epithelial-mesenchymal transition.
Xu G, Ge Y, Tao X, Gao Q, Liang X. | 05/19/2018 |
| In this study, through quantitative analysis of the complex formation between CagA and PAR1b, the authors found that several CagA species have acquired elevated PAR1b-binding activity via duplication of the CagA multimerization motifs, while others have lost their PAR1b-binding activity. | Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b.
Nishikawa H, Hayashi T, Arisaka F, Senda T, Hatakeyama M., Free PMC Article | 04/14/2018 |
| In the modeled structure of inactive MARK2, activation segment occludes the enzyme active site and assumes a relatively stable position. | Interconversion of inactive to active conformation of MARK2: Insights from molecular modeling and molecular dynamics simulation.
Ahrari S, Mogharrab N, Navapour L. | 09/9/2017 |
| In conclusion, baicalin and DDP were synergistic at inhibiting proliferation and invasion of human lung cancer cells at appropriate dosages and incubation time in the presence or absence of DDP resistance. The attenuation of DDP resistance was associated with downregulation of MARK2 and p-Akt. | Baicalin attenuates DDP (cisplatin) resistance in lung cancer by downregulating MARK2 and p-Akt.
Xu Z, Mei J, Tan Y. | 04/8/2017 |
| MARK2 plays a role in promoting malignant phenotypes of lung cancer. | Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SH, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL., Free PMC Article | 10/31/2015 |
| Phosphorylation of RNF41 by Par-1b regulates basolateral membrane targeting of laminin-111 receptors. | Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity.
Lewandowski KT, Piwnica-Worms H., Free PMC Article | 10/18/2014 |
| induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes | Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes.
Slim CL, Lázaro-Diéguez F, Bijlard M, Toussaint MJ, de Bruin A, Du Q, Müsch A, van Ijzendoorn SC., Free PMC Article | 08/9/2014 |
| Perturbation of PAR1b and SHP2 by CagA underlies the oncogenic potential of CagA. | Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1.
Hashi K, Murata-Kamiya N, Varon C, Mégraud F, Dominguez-Bello MG, Hatakeyama M., Free PMC Article | 05/10/2014 |
| The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail. | Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.
Schwalbe M, Biernat J, Bibow S, Ozenne V, Jensen MR, Kadavath H, Blackledge M, Mandelkow E, Zweckstetter M. | 03/8/2014 |
| Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA to yield the distinct epithelial division phenotypes. | Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes.
Lázaro-Diéguez F, Cohen D, Fernandez D, Hodgson L, van Ijzendoorn SC, Müsch A., Free PMC Article | 12/14/2013 |
| automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration. | Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells.
Nishimura Y, Applegate K, Davidson MW, Danuser G, Waterman CM., Free PMC Article | 03/16/2013 |
| The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. | The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.
Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG., Free PMC Article | 10/27/2012 |
| The results identify MARK2 as an upstream regulator of PINK1 and DeltaN-PINK1 and provide insights into the regulation of mitochondrial trafficking in neurons and neurodegeneration in PD. | Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport.
Matenia D, Hempp C, Timm T, Eikhof A, Mandelkow EM., Free PMC Article | 05/5/2012 |