| Epithelial membrane protein 2 (EMP2): A systematic review of its implications in pathogenesis. | Epithelial membrane protein 2 (EMP2): A systematic review of its implications in pathogenesis.
Mozaffari K, Mekonnen M, Harary M, Lum M, Aguirre B, Chandla A, Wadehra M, Yang I. | 01/28/2023 |
| Epithelial membrane protein 2 (EMP2) regulates hypoxia-induced angiogenesis in the adult retinal pigment epithelial cell lines. | Epithelial membrane protein 2 (EMP2) regulates hypoxia-induced angiogenesis in the adult retinal pigment epithelial cell lines.
Sun M, Cherian N, Liu L, Chan AM, Aguirre B, Chu A, Strawbridge J, Kim ES, Lin MC, Tsui I, Gordon LK, Wadehra M., Free PMC Article | 11/19/2022 |
| Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer. | Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.
Kim EK, Koo JS. | 04/9/2022 |
| EMP2 induces cytostasis and apoptosis via the TGFbeta/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma. | EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma.
Li CF, Chan TC, Pan CT, Vejvisithsakul PP, Lai JC, Chen SY, Hsu YW, Shiao MS, Shiue YL. | 02/12/2022 |
| Coexpression of PBX1 and EMP2 as Prognostic Biomarkers in Estrogen Receptor-Negative Breast Cancer via Data Mining. | Coexpression of PBX1 and EMP2 as Prognostic Biomarkers in Estrogen Receptor-Negative Breast Cancer via Data Mining.
Qiu Y, Lu G, Wu Y. | 09/25/2021 |
| EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells. | EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells.
Dillard C, Kiyohara M, Mah V, McDermott SP, Bazzoun D, Tsui J, Chan AM, Haddad G, Pellegrini M, Chang YL, Elshimali Y, Wu Y, Vadgama JV, Kim SR, Goodglick L, Law SM, Patel DD, Dhawan P, O'Brien NA, Gordon LK, Braun J, Lazar G, Wicha MS, Wadehra M., Free PMC Article | 06/5/2021 |
| Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway. | Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway.
Ma Y, Schröder DC, Nenkov M, Rizwan MN, Abubrig M, Sonnemann J, Murrieta-Coxca JM, Morales-Prieto DM, Westermann M, Gaßler N, Chen Y., Free PMC Article | 05/1/2021 |
| Identification of epithelial membrane protein 2 (EMP2) as a molecular marker and correlate for angiogenesis in meningioma. | Identification of epithelial membrane protein 2 (EMP2) as a molecular marker and correlate for angiogenesis in meningioma.
Patel KS, Kejriwal S, Sun MM, Thammachantha S, Duong C, Chan A, Cherian N, Romiyo P, Gordon LK, Yong W, Wadehra M, Yang I., Free PMC Article | 11/21/2020 |
| EMP2 had a significantly higher capture efficiency on MDA-MB-231 cells when compared to MCF7 cells | Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer.
Chen Q, Yao L, Burner D, Minev B, Lu L, Wang M, Ma W. | 07/13/2019 |
| miR-133b effectively binds to EMP2, down-regulates its expression and negates its normal function in glioma. | miR-133b acts as a tumor suppressor and negatively regulates EMP2 in glioma.
Zhang Q, Fan X, Xu B, Pang Q, Teng L. | 07/6/2019 |
| It is a biomarker in gliomas and may have use as a molecular target for the diagnosis and treatment of gliomas. | Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas.
Chung LK, Pelargos PE, Chan AM, Demos JV, Lagman C, Sheppard JP, Nguyen T, Chang YL, Hojat SA, Prins RM, Liau LM, Nghiemphu L, Lai A, Cloughesy TF, Yong WH, Gordon LK, Wadehra M, Yang I., Free PMC Article | 05/26/2018 |
| The studies implicating GAS3 protein family (EMP1, EMP2, EMP3 and PMP22) in cancer pathogenesis as well as probe the structural similarities between the family members were highlighted. | Review of the GAS3 Family of Proteins and their Relevance to Cancer.
Ashki N, Gordon L, Wadehra M., Free PMC Article | 02/3/2018 |
| High EMP2 expression is associated with endometrial cancer. | EMP2 is a novel therapeutic target for endometrial cancer stem cells.
Kiyohara MH, Dillard C, Tsui J, Kim SR, Lu J, Sachdev D, Goodglick L, Tong M, Torous VF, Aryasomayajula C, Wang W, Najafzadeh P, Gordon LK, Braun J, McDermott S, Wicha MS, Wadehra M., Free PMC Article | 10/28/2017 |
| Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1alpha expression. The results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans, and suggest that it may be a new biomarker for placental insufficiency. | Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency.
Williams CJ, Chu A, Jefferson WN, Casero D, Sudhakar D, Khurana N, Hogue CP, Aryasomayajula C, Patel P, Sullivan P, Padilla-Banks E, Mohandessi S, Janzen C, Wadehra M., Free PMC Article | 10/14/2017 |
| All studied ERMs and PVR membranes express EMP2. Levels of EMP2 trended higher in all PVR subgroups than in ERMs, especially in inflammatory and traumatic PVR. | Epithelial Membrane Protein-2 in Human Proliferative Vitreoretinopathy and Epiretinal Membranes.
Telander DG, Yu AK, Forward KI, Morales SA, Morse LS, Park SS, Gordon LK., Free PMC Article | 06/24/2017 |
| a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population. | Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.
Ke T, Dorajoo R, Han Y, Khor CC, van Dam RM, Yuan JM, Koh WP, Liu J, Teo YY, Goh DY, Tai ES, Wong TY, Cheng CY, Friedlander Y, Heng CK., Free PMC Article | 06/3/2017 |
| These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma. | EMP2 re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma.
Tang M, Liu RY, Zhou C, Yuan MZ, Wu DM, Yuan Z, Zhang P, Lang JY. | 04/8/2017 |
| Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). | Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells.
Lee EJ, Park MK, Kim HJ, Kim EJ, Kang GJ, Byun HJ, Lee CH. | 07/30/2016 |
| EMP2 plays a tumor suppressor role by inducing G2/M cell cycle arrest, suppressing cell viability, proliferation, colony formation/ anchorage-independent cell growth via regulation of G2/M checkpoints in distinct-derived cell lines. | The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma.
Li CF, Wu WJ, Wu WR, Liao YJ, Chen LR, Huang CN, Li CC, Li WM, Huang HY, Chen YL, Liang SS, Chow NH, Shiue YL., Free PMC Article | 03/5/2016 |
| Loss of EMP2 is associated with nasopharyngeal carcinoma. | Immunohistochemical expression of cytokeratins and epithelial membrane protein 2 in nasopharyngeal carcinoma and its potential implications.
Ahmed HG, Abdul Gader Suliman RS, Abd El Aziz MS, Alshammari FD. | 12/19/2015 |
| the role of EMP2 in the pathogenesis of GBM a | Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma.
Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M., Free PMC Article | 12/20/2014 |
| We showed that knockdown of EMP2 in podocytes and endothelial cells resulted in an increased amount of CAVEOLIN-1 and decreased cell proliferation, so EMP2 mutations causes a recessive Mendelian form of steroid-sensitive nephrotic syndrome. | Mutations in EMP2 cause childhood-onset nephrotic syndrome.
Gee HY, Ashraf S, Wan X, Vega-Warner V, Esteve-Rudd J, Lovric S, Fang H, Hurd TW, Sadowski CE, Allen SJ, Otto EA, Korkmaz E, Washburn J, Levy S, Williams DS, Bakkaloglu SA, Zolotnitskaya A, Ozaltin F, Zhou W, Hildebrandt F., Free PMC Article | 08/9/2014 |
| EMP2 was identified as a tumor-suppressor gene in urinary tract urothelial carcinoma. | Epithelial membrane protein 2 is a prognostic indictor for patients with urothelial carcinoma of the upper urinary tract.
Wang YW, Li WM, Wu WJ, Chai CY, Chang TY, Sun Y, Cheng CJ, Shiue YL, Su SJ, Cheng HL, Liu HS, Chow NH. | 03/15/2014 |
| support the role of EMP2 in the control of the tumor microenvironment and confirm the cytotoxic effects observed by EMP2 treatment in vivo | EMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF.
Gordon LK, Kiyohara M, Fu M, Braun J, Dhawan P, Chan A, Goodglick L, Wadehra M., Free PMC Article | 01/18/2014 |
| EMP2 is expressed in the majority of ovarian tumors and may be a feasible target in vivo. | Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer.
Fu M, Maresh EL, Soslow RA, Alavi M, Mah V, Zhou Q, Iasonos A, Goodglick L, Gordon LK, Braun J, Wadehra M., Free PMC Article | 11/27/2010 |