| Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10. | Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
Nakamura Y, Ito MA, Hoshino Y, Matsuoka I, Okada T, Okada Y, Nakanishi T. | 03/29/2024 |
| S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice. | S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice.
Liu H, Sun J, Wang Z, Han R, Zhao Y, Lou Y, Wang H. | 02/13/2024 |
| Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice. | Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice.
Seo MK, Lee JG, Park SW., Free PMC Article | 11/6/2021 |
| Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection. | Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Lou Y, Han M, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H., Free PMC Article | 10/2/2021 |
| Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. | Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.
Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y., Free PMC Article | 03/20/2021 |
| P11 is involved in regulating fibroblast cell proliferation and cell size. We observed anxiety-like disorder in addition to depression phenotype in the knockout mice. | P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice.
Liu G, Wang Y, Zheng W, Cheng H, Zhou R., Free PMC Article | 04/11/2020 |
| Study reports that the transcription factor Sp1 controls p11 expression, which impacts on excitability by hampering functional expression of TASK1. In the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS), Sp1-p11-TASK1 dysregulation contributes to increased excitability and vulnerability of motor neurons. Interference with either Sp1 or p11 delays neuron loss and prolongs lifespan in this model. | Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1.
García-Morales V, Rodríguez-Bey G, Gómez-Pérez L, Domínguez-Vías G, González-Forero D, Portillo F, Campos-Caro A, Gento-Caro Á, Issaoui N, Soler RM, Garcera A, Moreno-López B., Free PMC Article | 01/4/2020 |
| p11KO male mice showed lower conditioned place preference than WT. In females there were no CPP differences between p11KO and WT. | Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice.
Thanos PK, Malave L, Delis F, Mangine P, Kane K, Grunseich A, Vitale M, Greengard P, Volkow ND. | 12/23/2017 |
| p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-alpha-induced depression. | Probable involvement of p11 with interferon alpha induced depression.
Guo J, Zhang W, Zhang L, Ding H, Zhang J, Song C, Zhang Y, Xia N, Li M, Liang Y, Hu X, Luan H, Wang H., Free PMC Article | 01/14/2017 |
| data indicate that focal inhibition of p11 action in the dorsal striatum could be a promising PD therapeutic target to improve motor function while reducing l-dopa-induced dyskinesias | Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.
Marongiu R, Arango-Lievano M, Francardo V, Morgenstern P, Zhang X, Cenci MA, Svenningsson P, Greengard P, Kaplitt MG., Free PMC Article | 08/13/2016 |
| p11 homeostasis in the NAc, particularly in dopamine receptor-1 expressing medium spiny neurons, may underlie pathophysiological mechanisms of cocaine rewarding action. | Cell-type specific expression of p11 controls cocaine reward.
Arango-Lievano M, Schwarz JT, Vernov M, Wilkinson MB, Bradbury K, Feliz A, Marongiu R, Gelfand Y, Warner-Schmidt J, Nestler EJ, Greengard P, Russo SJ, Kaplitt MG., Free PMC Article | 08/1/2015 |
| The level of hippocampal p11 determines the directionality of 5-HT(1B)R action on emotional memory processing and modulates hippocampal functionality. | Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.
Eriksson TM, Alvarsson A, Stan TL, Zhang X, Hascup KN, Hascup ER, Kehr J, Gerhardt GA, Warner-Schmidt J, Arango-Lievano M, Kaplitt MG, Ogren SO, Greengard P, Svenningsson P., Free PMC Article | 05/31/2014 |
| p11 and AnxA2 cooperate to create a unique binding pocket, but the optimal binding condition is not achieved without conformational changes associated with target binding. Upon interaction with the SMARCA3 peptide, both Asp60 in p11 and Ser12 in AnxA2 flip inward toward the peptide-binding groove, forming additional intermolecular hydrogen bonds. | SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.
Oh YS, Gao P, Lee KW, Ceglia I, Seo JS, Zhang X, Ahn JH, Chait BT, Patel DJ, Kim Y, Greengard P., Free PMC Article | 04/20/2013 |
| Lewis lung carcinoma or T241 fibrosarcoma growth was reduced in S100A10-deficient mice. S100A10 was required specifically for the migratory capability needed for macrophage tumor homing, a new rate-limiting step in tumor progression. | Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites.
Phipps KD, Surette AP, O'Connell PA, Waisman DM. | 01/14/2012 |
| An important role for S100A10 in the regulation of fibrinolysis and angiogenesis in vivo, suggesting that S100A10 plays a critical role in endothelial cell function. | Regulation of fibrinolysis by S100A10 in vivo.
Surette AP, Madureira PA, Phipps KD, Miller VA, Svenningsson P, Waisman DM. | 11/26/2011 |
| Data indicate that most p11 expressing cells in cerebral cortex, hippocampus, cerebellum, & caudate-putamen express HTR1B or co-express HTR1B/HTR4, suggesting crucial role for p11 in modulating actions of serotonin via these receptor subtypes. | Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum.
Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. | 10/15/2011 |
| The authors inferred that S100A10 may play an important role in transpenetration of Cryptococcus neoformans across the vascular endothelia. | S100A10 downregulation inhibits the phagocytosis of Cryptococcus neoformans by murine brain microvascular endothelial cells.
Chen Y, Chen J, Wen H, Gao P, Wang J, Zheng Z, Gu J. | 10/8/2011 |
| Voluntary physical activity, but not locked wheel exposure, induced a robust increase in hippocampal mature BDNF protein levels, as well as in p11 and tissue plasminogen activator mRNA expression | The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA.
Sartori CR, Vieira AS, Ferrari EM, Langone F, Tongiorgi E, Parada CA. | 08/6/2011 |
| data demonstrate that p11 levels are regulated by BDNF in vitro and in vivo and that the antidepressantlike effect of BDNF in two well-established behavioral models requires p11. | A role for p11 in the antidepressant action of brain-derived neurotrophic factor.
Warner-Schmidt JL, Chen EY, Zhang X, Marshall JJ, Morozov A, Svenningsson P, Greengard P., Free PMC Article | 01/22/2011 |
| Loss of S100A10 led to decrease in macrophage migration across the peritoneal membrane into the peritoneal cavity. | S100A10 regulates plasminogen-dependent macrophage invasion.
O'Connell PA, Surette AP, Liwski RS, Svenningsson P, Waisman DM. | 10/4/2010 |
| S100a10 (p11) and 5-ht4 receptor cross-talking and cooexpression in brain regions play a role in major depression. | Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation.
Warner-Schmidt JL, Flajolet M, Maller A, Chen EY, Qi H, Svenningsson P, Greengard P., Free PMC Article | 01/21/2010 |
| S100A10 mRNA and protein levels were significantly lower in the cultured ANXA2(-/-) cells than in cultured ANXA2(+/+) cells. | Annexin A2 regulates the levels of plasmin, S100A10 and Fascin in L5178Y cells.
Hou Y, Yang L, Mou M, Hou Y, Zhang A, Pan N, Qiang R, Wei L, Zhang N. | 01/21/2010 |
| Within the endothelial cell, p11 is required for Src kinase-mediated tyrosine phosphorylation of A2, which signals translocation of both proteins to the cell surface. | Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11.
He KL, Deora AB, Xiong H, Ling Q, Weksler BB, Niesvizky R, Hajjar KA., Free PMC Article | 01/21/2010 |
| We have recently identified increased expression of p11 genes that implicate fibrinolysis in ALD progression. | Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.
Seth D, Hogg PJ, Gorrell MD, McCaughan GW, Haber PS. | 01/21/2010 |
| results of the present study indicate that the dynamic modulation of 5-HT1B receptor function by p11 may be involved in molecular adaptations occurring in neuronal networks that are dysfunctional in depression-like states | Alterations in 5-HT1B receptor function by p11 in depression-like states.
Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P. | 01/21/2010 |