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    Saa3 serum amyloid A 3 [ Mus musculus (house mouse) ]

    Gene ID: 20210, updated on 23-Jun-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.

    The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.
    Kumrungsee T, Kariya T, Hashimoto K, Koyano T, Yazawa N, Hashimoto T, Sanada Y, Matsuyama M, Sotomaru Y, Sakurai H, van de Loo FAJ, Yanaka N., Free PMC Article

    10/31/2020
    Potential of Mesenchymal stem cells-exosomes overexpressing miR-30b-3p in preventing acute lung injury. These exosomes protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3.

    Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3.
    Yi X, Wei X, Lv H, An Y, Li L, Lu P, Yang Y, Zhang Q, Yi H, Chen G.

    07/4/2020
    These findings demonstrate that SAA3 not only serves as a biomarker for infection and inflammation, but also plays a protective role against P. aeruginosa infection-induced lung injury.

    Serum amyloid A3 confers protection against acute lung injury in <i>Pseudomonas aeruginosa</i>-infected mice.
    Fan Y, Zhang G, Vong CT, Ye RD.

    05/16/2020
    Up-regulation of serum amyloid A3 mRNA expression after stimulation with lipopolysaccharide and lipoteichoic acid in mouse lung cells.

    Up-regulation of serum amyloid A3 mRNA expression after stimulation with lipopolysaccharide and lipoteichoic acid in mouse lung cells.
    Inoshima Y, Iwata A, Okada A.

    01/18/2020
    Findings indicate that endogenous SAA3 regulates lung development and homeostasis, and is required for protection against H1N1 influenza infection.

    Serum Amyloid A3 is required for normal lung development and survival following influenza infection.
    Ather JL, Dienz O, Boyson JE, Anathy V, Amiel E, Poynter ME., Free PMC Article

    11/2/2019
    SAA3 is a major hepatic acute-phase SAA in mice that may produce systemic effects during inflammation

    Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein.
    Tannock LR, De Beer MC, Ji A, Shridas P, Noffsinger VP, den Hartigh L, Chait A, De Beer FC, Webb NR., Free PMC Article

    07/20/2019
    SAA3 augments atherosclerosis in ApoE-knockout mice.

    Serum amyloid A3 is pro-atherogenic.
    Thompson JC, Wilson PG, Shridas P, Ji A, de Beer M, de Beer FC, Webb NR, Tannock LR., Free PMC Article

    06/1/2019
    N-terminal region of serum amyloid A3 is responsible for up-regulation of MUC2 mRNA expression in mouse epithelial cells.

    N-terminal region of serum amyloid A3 is responsible for up-regulation of MUC2 mRNA expression in mouse epithelial cells.
    Inoshima Y, Tashiro M, Ishiguro N.

    02/2/2019
    High SAA3 expression in the stromal component is associated with pancreatic tumors.

    Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
    Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B Jr, Al-Shahrour F, Rabadan R, Guerra C, Barbacid M., Free PMC Article

    07/28/2018
    This study suggests that the level of expression of the Saa3 gene could be utilized for the number of infiltrated macrophages in obese adipose tissue.

    Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages.
    Sanada Y, Yamamoto T, Satake R, Yamashita A, Kanai S, Kato N, van de Loo FA, Nishimura F, Scherer PE, Yanaka N., Free PMC Article

    06/9/2018
    BMDC lacking SAA3 demonstrate an impaired endotoxin tolerance response and inhibited responses to retinoic acid. Our findings indicate that endogenous SAA3 modulates metabolic and immune homeostasis

    Serum amyloid A3 is required for normal weight and immunometabolic function in mice.
    Ather JL, Poynter ME., Free PMC Article

    04/21/2018
    The induction of Saa3 by PTH may explain the suppression of bone formation when PTH is applied continuously and may be a new therapeutic target for osteoporosis.

    Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts.
    Choudhary S, Goetjen A, Estus T, Jacome-Galarza CE, Aguila HL, Lorenzo J, Pilbeam C., Free PMC Article

    07/2/2016
    results also suggest that Saa3 influences liver-specific SAA1/2 expression, and that SAA3 could play a larger role in the acute phase response than previously thought

    Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice.
    den Hartigh LJ, Wang S, Goodspeed L, Ding Y, Averill M, Subramanian S, Wietecha T, O'Brien KD, Chait A., Free PMC Article

    12/19/2015
    Expression of Saa3 in osteoblasts positively correlates with increased cellular maturation toward the osteocyte phenotype.

    Acute-phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis.
    Thaler R, Sturmlechner I, Spitzer S, Riester SM, Rumpler M, Zwerina J, Klaushofer K, van Wijnen AJ, Varga F., Free PMC Article

    06/27/2015
    Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.

    Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.
    Derebe MG, Zlatkov CM, Gattu S, Ruhn KA, Vaishnava S, Diehl GE, MacMillan JB, Williams NS, Hooper LV., Free PMC Article

    05/16/2015
    These results suggest that SAA3 plays a role in host innate immunity in the colon by up-regulating MUC2 mucin production, which builds a physiological barrier of colonic epithelia against bacterial invasion.

    Up-regulation of MUC2 mucin expression by serum amyloid A3 protein in mouse colonic epithelial cells.
    Shigemura H, Ishiguro N, Inoshima Y., Free PMC Article

    04/18/2015
    these data suggest a novel mechanism by which Mo MDSCs mediate inflammation through SAA3-TLR2 signaling and thus exacerbate cancer progression by a STAT3-dependent mechanism.

    Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid-derived suppressor cells via TLR2-dependent STAT3 activation.
    Lee JM, Kim EK, Seo H, Jeon I, Chae MJ, Park YJ, Song B, Kim YS, Kim YJ, Ko HJ, Kang CY.

    07/26/2014
    Hypoxia leads to a substantial increase in SAA3 mRNA and protein level, apparently in a time-dependent manner (threefold in 48 h), in fully differentiated 3T3-L1, followed by reestablishment of gene expression to basal levels after 24 h of reoxygenation.

    Hypoxia increases serum amyloid A3 (SAA3) in differentiated 3T3-L1 adipocytes.
    de Oliveira EM, Sandri S, Knebel FH, Contesini CG, Campa A, Filippin-Monteiro FB.

    04/26/2014
    Using various synthetic peptide fragments, it was shown that SAA3 directly binds MD-2 and activates the MyD88-dependent TLR4/MD-2 pathway, induced IL-6 and TNF-alpha, and recruited CD11b(+)Gr-1(+) cells to the lung.

    Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner.
    Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, Maru Y.

    03/22/2014
    HSV-1 induces and activate TLR2 and TLR4 receptors directly through interaction of astrocytes with the pathogen and also indirectly by endogenous ligands produced locally, such as serum amyloid A, potentiating the neuroinflammatory response.

    Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ligand serum amyloid A in astrocytes.
    Villalba M, Hott M, Martin C, Aguila B, Valdivia S, Quezada C, Zambrano A, Concha MI, Otth C.

    12/8/2012
    Saa3 is expressed in the lungs of mice exposed to several mixed T helper (Th) type 2/Th17-polarizing allergic sensitization regimen and is implicated in the pathogenesis of experimental allergic asthma.

    Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
    Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME., Free PMC Article

    09/3/2011
    cAMP in combination with TNF specifically induced C/EBPbeta protein, leading to enhanced SAA3 expression but requiring NF-kappaB in mouse granulose cells. The data indicate SAA may play a role in events occurring during the ovulation process.

    Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform.
    Son DS, Terranova PF, Roby KF., Free PMC Article

    07/12/2010
    Results indicate that the expression of SAA3 in adipose tissue is upregulated by obesity, but it does not contribute to the circulating pool of SAA in mice.

    Serum amyloid A3 does not contribute to circulating SAA levels.
    Chiba T, Han CY, Vaisar T, Shimokado K, Kargi A, Chen MH, Wang S, McDonald TO, O'Brien KD, Heinecke JW, Chait A., Free PMC Article

    01/21/2010
    serum amyloid A3 (SAA3) is regulated in mouse colonic epithelium and adipose tissue by the intestinal microbiota

    Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota.
    Reigstad CS, Lundén GO, Felin J, Bäckhed F., Free PMC Article

    01/21/2010
    The Caga-Saa3-Tlr4 paracrine cascade establishes a pre-metastatic phase.

    The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
    Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y.

    01/21/2010
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