Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na[+] Channel (ENaC). | Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na(+) Channel (ENaC). Duan XP, Xiao Y, Su XT, Zheng JY, Gurley S, Emathinger J, Yang CL, McCormick J, Ellison DH, Lin DH, Wang WH., | 01/6/2024 |
Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity. | Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity. Ehret E, Stroh S, Auberson M, Ino F, Jäger Y, Maillard M, Szabo R, Bugge TH, Frateschi S, Hummler E., Free PMC Article | 11/28/2023 |
P2Y2 receptor decreases blood pressure by inhibiting ENaC. | P2Y2 receptor decreases blood pressure by inhibiting ENaC. Soares AG, Contreras J, Mironova E, Archer CR, Stockand JD, Abd El-Aziz TM., Free PMC Article | 07/25/2023 |
Accessibility of ENaC extracellular domain central core residues. | Accessibility of ENaC extracellular domain central core residues. Zhang L, Wang X, Chen J, Kleyman TR, Sheng S., Free PMC Article | 06/11/2022 |
Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway. | Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway. Xie X, Yu T, Hou Y, Han A, Ding Y, Nie H, Cui Y., Free PMC Article | 03/19/2022 |
Cell-specific EnNaC is important in propagating pulsatility into the renal circulation, generating oxidant stress, reduced bioavailable NO, and renal vessel wall fibrosis and stiffening. | Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na(+) channel. Xiong Y, Aroor AR, Ramirez-Perez FI, Jia G, Habibi J, Manrique-Acevedo C, Lastra G, Chen D, DeMarco VG, Martinez-Lemus LA, Hill MA, Jaisser F, Sowers JR, Whaley-Connell A., Free PMC Article | 07/18/2020 |
Estrogen treatment decreased alpha-ENaC expression but increased derlin-1 expression in mouse renal collecting duct (mpkCCDc14) cells. | Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation. Zhang X, Ge Y, Bukhari AA, Zhu Q, Shen Y, Li M, Sun H, Su D, Liang X., Free PMC Article | 06/20/2020 |
Epithelial Na(+) channel's (ENaC) able to mediate shear force responsiveness relies on the "force-from-filament" principle involving extracellular tethers and the extracellular matrix. Two glycosylated asparagines, respectively their N-glycans localized in the palm and knuckle domains of alphaENaC, were identified as potential tethers. Endothelial-specific overexpression of alphaENaC in mice induced hypertension. | Shear force sensing of epithelial Na(+) channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. Knoepp F, Ashley Z, Barth D, Baldin JP, Jennings M, Kazantseva M, Saw EL, Katare R, Alvarez de la Rosa D, Weissmann N, Fronius M., Free PMC Article | 05/9/2020 |
Autosomal dominant polycystic kidney disease cysts epithelia exhibit a hyperexpression of pannexin-1 and P2X7 proteins. Pannexin-1 in renal epithelial cells mediates ATP release into the lumen. P2X7 activation shown earlier to facilitate Panx1 conductance, reduces ENaC activity. | ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity. Arkhipov SN, Pavlov TS., Free PMC Article | 04/11/2020 |
This study demonstrates that CLDN7 plays an important role in salt balance in renal CD cells and modulating WNK4 and ENaC expression levels that are vital in controlling salt-sensitive hypertension. | Claudin-7 Modulates Cl(-) and Na(+) Homeostasis and WNK4 Expression in Renal Collecting Duct Cells. Fan J, Tatum R, Hoggard J, Chen YH., Free PMC Article | 01/11/2020 |
The absence of endothelial alphaENaC expression reduced the severity of renal dysfunction following renal ischemia/reperfusion injury. | The Absence of Endothelial Sodium Channel α (αENaC) Reduces Renal Ischemia/Reperfusion Injury. Tarjus A, González-Rivas C, Amador-Martínez I, Bonnard B, López-Marure R, Jaisser F, Barrera-Chimal J., Free PMC Article | 12/7/2019 |
AT1a R deficiency elicits a complex inhibitory effect on ENaC activity. | Compromised regulation of the collecting duct ENaC activity in mice lacking AT(1a) receptor. Mamenko M, Zaika O, Tomilin V, Jensen VB, Pochynyuk O., Free PMC Article | 10/5/2019 |
Here, the authors report that the epithelial sodium channel (ENaC) is upregulated and activated in the uterus at labor in mice. | Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. Sun X, Guo JH, Zhang D, Chen JJ, Lin WY, Huang Y, Chen H, Huang WQ, Liu Y, Tsang LL, Yu MK, Chung YW, Jiang X, Huang H, Chan HC, Ruan YC., Free PMC Article | 06/1/2019 |
the results of the present study demonstrated that insulin protected the lung epithelium and attenuated pulmonary edema through the upregulation of ENaC via the PI3K/SGK1 pathway in LPSinduced lung injury. | Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide‑induced lung injury. Deng W, Li CY, Tong J, He J, Zhao Y, Wang DX., Free PMC Article | 05/25/2019 |
Casein kinase 2 phosphorylation is an important regulator of ENaC activity and sodium handling by the aldosterone sensitive distal nephron. | Physiological regulation of the epithelial Na(+) channel by casein kinase II. Berman JM, Mironova E, Stockand JD., Free PMC Article | 05/4/2019 |
N-linked glycans on each subunit are required for proper folding, maturation, surface expression, and function of the epithelial sodium channel. | N-linked glycans are required on epithelial Na(+) channel subunits for maturation and surface expression. Kashlan OB, Kinlough CL, Myerburg MM, Shi S, Chen J, Blobner BM, Buck TM, Brodsky JL, Hughey RP, Kleyman TR., Free PMC Article | 05/4/2019 |
Based on the widespread presence of ENaC along the epididymis we suggest that mutations in ENaC subunits may also be associated with male infertility. | Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis. Sharma S, Hanukoglu I. | 05/4/2019 |
Epithelial sodium channel alpha subunit knpckout (Scnn1a-/-} represses inward Na+ currents in culturedendothelial cell (ECs). | Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction. Jia G, Habibi J, Aroor AR, Hill MA, Yang Y, Whaley-Connell A, Jaisser F, Sowers JR., Free PMC Article | 04/13/2019 |
These findings indicate that AMPK promotes the assembly of beta1Pix, 14-3-3 proteins, and Nedd4-2 into a complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and its degradation. | β(1)Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR., Free PMC Article | 02/9/2019 |
Aldosterone promotes increased interaction of NCC and ENaC. | Aldosterone Modulates the Association between NCC and ENaC. Wynne BM, Mistry AC, Al-Khalili O, Mallick R, Theilig F, Eaton DC, Hoover RS., Free PMC Article | 01/12/2019 |
Increased ENAC alpha, beta and gamma subunits expression is associated with Lung disease. | Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways. Livraghi-Butrico A, Wilkinson KJ, Volmer AS, Gilmore RC, Rogers TD, Caldwell RA, Burns KA, Esther CR Jr, Mall MA, Boucher RC, O'Neal WK, Grubb BR., Free PMC Article | 12/22/2018 |
The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells. | Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC. You H, Ge Y, Zhang J, Cao Y, Xing J, Su D, Huang Y, Li M, Qu S, Sun F, Liang X. | 08/12/2017 |
ENaC activity is regulated by calpain-2 proteolysis of MARCKS. | ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins. Montgomery DS, Yu L, Ghazi ZM, Thai TL, Al-Khalili O, Ma HP, Eaton DC, Alli AA., Free PMC Article | 08/5/2017 |
nonselective cation channels ( channels consist of at least one alpha-ENaC and one or more acid-sensing ion channel 1a (ASIC1a) proteins. | Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC. Trac PT, Thai TL, Linck V, Zou L, Greenlee M, Yue Q, Al-Khalili O, Alli AA, Eaton AF, Eaton DC., Free PMC Article | 08/5/2017 |
ENaC and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC and ROMK may contribute to the suppression of K(+) secretion in the tubules. | ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4(PHAII) mice. Zhang C, Wang L, Su XT, Zhang J, Lin DH, Wang WH., Free PMC Article | 07/15/2017 |