| Both FABP1 and SCP-2 participate in regulating the Brain endocannabinoids (EC) system in the brain. | Sterol Carrier Protein-2/Sterol Carrier Protein-x/Fatty Acid Binding Protein-1 Ablation Impacts Response of Brain Endocannabinoid to High-Fat Diet.
Martin GG, Seeger DR, McIntosh AL, Milligan S, Chung S, Landrock D, Dangott LJ, Golovko MY, Murphy EJ, Kier AB, Schroeder F. | 05/16/2020 |
| These findings suggested that ablation of the Scp-2/Scp-x gene in Fabp1 null mice exacerbated hepatic endocannabinoid (EC) accumulation and antagonized the impact of high fat diet on hepatic EC levels-suggesting both proteins play important roles in regulating the hepatic EC system. | Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat.
Martin GG, Seeger DR, McIntosh AL, Chung S, Milligan S, Landrock D, Dangott LJ, Golovko MY, Murphy EJ, Kier AB, Schroeder F., Free PMC Article | 06/29/2019 |
| These results indicate an important regulatory role for SCP2 deficiency in attenuating diet-induced atherosclerosis by limiting intestinal cholesterol absorption and decreasing hepatic triglyceride/VLDL secretion. | Sterol carrier protein-2 deficiency attenuates diet-induced dyslipidemia and atherosclerosis in mice.
He H, Wang J, Yannie PJ, Kakiyama G, Korzun WJ, Ghosh S., Free PMC Article | 01/26/2019 |
| Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice | Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.
Milligan S, Martin GG, Landrock D, McIntosh AL, Mackie JT, Schroeder F, Kier AB., Free PMC Article | 04/21/2018 |
| role of Fabp1/Scp-2 in hepatic phytol metabolism | Impact of Fabp1/Scp-2/Scp-x gene ablation (TKO) on hepatic phytol metabolism in mice.
Storey SM, Huang H, McIntosh AL, Martin GG, Kier AB, Schroeder F., Free PMC Article | 01/20/2018 |
| Thus, the loss of Scp-2/Scp-x contributed to a sex-dependent hepatic accumulation of dietary phytol and BCFA. | Sex-dependent impact of Scp-2/Scp-x gene ablation on hepatic phytol metabolism.
McIntosh AL, Storey SM, Huang H, Kier AB, Schroeder F., Free PMC Article | 12/2/2017 |
| Individually ablating SCPx or SCP2/SCPx elicited concomitant upregulation of L-FABP. | Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.
Milligan S, Martin GG, Landrock D, McIntosh AL, Mackie JT, Schroeder F, Kier AB., Free PMC Article | 10/21/2017 |
| Lack of a significant decrease in the flux of HDL-[(3)H]CE to biliary FC or bile acids in FABP1(-/-) mice indicates the likely compensation of its function by an as yet unidentified mechanism. Taken together, these studies demonstrate that FABP1 and SCP2 facilitate the preferential movement of HDL-CEs to bile for final elimination | Intracellular cholesterol transport proteins enhance hydrolysis of HDL-CEs and facilitate elimination of cholesterol into bile.
Wang J, Bie J, Ghosh S., Free PMC Article | 09/2/2017 |
| Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells | Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells.
Li NC, Fan J, Papadopoulos V., Free PMC Article | 07/30/2016 |
| L-FABP was more important in hepatic retention of bile acids, while SCP-2/SCP-x more broadly affected biliary bile acid and phospholipid levels. | Relative contributions of L-FABP, SCP-2/SCP-x, or both to hepatic biliary phenotype of female mice.
Martin GG, Landrock D, Landrock KK, Howles PN, Atshaves BP, Kier AB, Schroeder F., Free PMC Article | 04/23/2016 |
| Loss of L-FABP and SCP-2, or both induces hepatic lipid accumulation in female mice and mimics non-alcoholic fatty liver disease. | Loss of L-FABP, SCP-2/SCP-x, or both induces hepatic lipid accumulation in female mice.
Martin GG, Atshaves BP, Landrock KK, Landrock D, Schroeder F, Kier AB., Free PMC Article | 10/10/2015 |
| SCP-2/SCP-x may function more in formation and biliary secretion of bile acid, with less impact on hepatic uptake or biliary secretion of HDL-cholesterol | Ablating L-FABP in SCP-2/SCP-x null mice impairs bile acid metabolism and biliary HDL-cholesterol secretion.
Martin GG, Atshaves BP, Landrock KK, Landrock D, Storey SM, Howles PN, Kier AB, Schroeder F., Free PMC Article | 01/24/2015 |
| liver fatty acid-binding protein, the single most prevalent hepatic cytosolic protein that binds cholesterol, was upregulated twofold in SCP-2 null hepatocytes | Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes.
Storey SM, McIntosh AL, Huang H, Landrock KK, Martin GG, Landrock D, Payne HR, Atshaves BP, Kier AB, Schroeder F., Free PMC Article | 06/2/2012 |
| SCP-2 expression plays a significant role in HDL-mediated cholesterol efflux by regulating the size of rapid vs. slow cholesterol efflux pools and/or eliciting concomitant upregulation of L-FABP in cultured primary hepatocytes. | Effect of sterol carrier protein-2 gene ablation on HDL-mediated cholesterol efflux from cultured primary mouse hepatocytes.
Storey SM, Atshaves BP, McIntosh AL, Landrock KK, Martin GG, Huang H, Ross Payne H, Johnson JD, Macfarlane RD, Kier AB, Schroeder F., Free PMC Article | 07/19/2010 |
| Results support an important role for SCP-2 in hepatic cholesterol homeostasis. | Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice.
Atshaves BP, McIntosh AL, Martin GG, Landrock D, Payne HR, Bhuvanendran S, Landrock KK, Lyuksyutova OI, Johnson JD, Macfarlane RD, Kier AB, Schroeder F., Free PMC Article | 01/21/2010 |
| SCP-2/SCP-x has a role in regulating lipid raft domains in primary cultured mouse hepatocytes | SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes.
Atshaves BP, McIntosh AL, Payne HR, Gallegos AM, Landrock K, Maeda N, Kier AB, Schroeder F. | 01/21/2010 |
| Results suggest a key regulatory role for sterol carrier protein-2 in hepatic lipid metabolism. | Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion.
Amigo L, Zanlungo S, Miquel JF, Glick JM, Hyogo H, Cohen DE, Rigotti A, Nervi F. | 01/21/2010 |
| Results demonstrate a direct physiological relationship between lack of SCP-x and decreased ability to metabolize branched-chain lipids. | Effect of SCP-x gene ablation on branched-chain fatty acid metabolism.
Atshaves BP, McIntosh AL, Landrock D, Payne HR, Mackie JT, Maeda N, Ball J, Schroeder F, Kier AB. | 01/21/2010 |
| Effect of Scp2 expression on the rate of sterol transfer from lysosomal membranes, and lysosomal membrane lipid distribution. | Molecular and fluorescent sterol approaches to probing lysosomal membrane lipid dynamics.
Gallegos AM, Atshaves BP, Storey S, Schoer J, Kier AB, Schroeder F. | 01/21/2010 |
| SCP-2 and SCP-x stimulate oxidation and esterification of branched-chain as well as straight-chain fatty acids in intact cells. | Sterol carrier protein-2/sterol carrier protein-x expression differentially alters fatty acid metabolism in L cell fibroblasts.
Atshaves BP, Storey SM, Schroeder F. | 01/21/2010 |
| Regulation of the SCPx gene by SF-1 and cAMP is similar to the regulatory mechanisms observed for other steroidogenic genes. | Activation of the SCPx promoter in mouse adrenocortical Y1 cells.
Lopez D, Niesen M, Bedi M, Hale D, McLean MP. | 01/21/2010 |
| SCP-2 contributes to the accumulation of cholesterol in L-FABP null liver | Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene.
Martin GG, Danneberg H, Kumar LS, Atshaves BP, Erol E, Bader M, Schroeder F, Binas B. | 01/21/2010 |
| Data show that expression of sterol carrier protein-2 (SCP-2) increased fatty acid uptake and targeted fatty acid to unique lipid pools, suggesting that SCP-2 may effectively serve as universal fatty acid binding and trafficking protein. | Sterol carrier protein-2: not just for cholesterol any more.
Murphy EJ. | 01/21/2010 |