| PSGL-1 is an evolutionarily conserved antiviral restriction factor. | PSGL-1 is an evolutionarily conserved antiviral restriction factor.
Jiang C, Mei M, Liu Y, Hou M, Jiao J, Tan Y, Tan X., Free PMC Article | 01/3/2024 |
| B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury. | B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
Li GX, Jiang XH, Zang JN, Zhu BZ, Jia CC, Niu KW, Liu X, Jiang R, Wang B., Free PMC Article | 11/15/2023 |
| High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca[2+]/PAD4 pathway to exacerbate acute pancreatitis. | High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca(2+)/PAD4 pathway to exacerbate acute pancreatitis.
Xu Q, Shi M, Ding L, Xia Y, Luo L, Lu X, Zhang X, Deng DYB., Free PMC Article | 10/25/2023 |
| Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation. | Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
Goth CK, Mehta AY, McQuillan AM, Baker KJ, Hanes MS, Park SS, Stavenhagen K, Hjortø GM, Heimburg-Molinaro J, Chaikof EL, Rosenkilde MM, Cummings RD., | 08/25/2023 |
| Targeted nanotherapy with everolimus reduces inflammation and fibrosis in scleroderma-related interstitial lung disease developed by PSGL-1 deficient mice. | Targeted nanotherapy with everolimus reduces inflammation and fibrosis in scleroderma-related interstitial lung disease developed by PSGL-1 deficient mice.
González-Sánchez E, Muñoz-Callejas A, Gómez-Román J, San Antonio E, Marengo A, Tsapis N, Bohne-Japiassu K, González-Tajuelo R, Pereda S, García-Pérez J, Cavagna L, González-Gay MÁ, Vicente-Rabaneda EF, Meloni F, Fattal E, Castañeda S, Urzainqui A. | 08/27/2022 |
| P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt. | P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt.
Wu X, Liu X, Yang H, Chen Q, Zhang N, Li Y, Du X, Liu X, Jiang X, Jiang Y, Zhou Z, Yang Z. | 02/26/2022 |
| P-selectin deficiency promotes liver senescence in sickle cell disease mice. | P-selectin deficiency promotes liver senescence in sickle cell disease mice.
Vats R, Kaminski TW, Ju EM, Brozska T, Tutuncuoglu E, Tejero J, Novelli EM, Sundd P, Pradhan-Sundd T., Free PMC Article | 12/11/2021 |
| Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis. | Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.
Man JJ, Lu Q, Moss ME, Carvajal B, Baur W, Garza AE, Freeman R, Anastasiou M, Ngwenyama N, Adler GK, Alcaide P, Jaffe IZ., Free PMC Article | 11/27/2021 |
| PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection. | PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection.
Tinoco R, Neubert EN, Stairiker CJ, Henriquez ML, Bradley LM., Free PMC Article | 10/30/2021 |
| Relevance of PSGL-1 Expression in B Cell Development and Activation. | Relevance of PSGL-1 Expression in B Cell Development and Activation.
González-Tajuelo R, González-Sánchez E, Silván J, Muñoz-Callejas A, Vicente-Rabaneda E, García-Pérez J, Castañeda S, Urzainqui A., Free PMC Article | 07/17/2021 |
| P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression. | P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression.
Yeini E, Ofek P, Pozzi S, Albeck N, Ben-Shushan D, Tiram G, Golan S, Kleiner R, Sheinin R, Israeli Dangoor S, Reich-Zeliger S, Grossman R, Ram Z, Brem H, Hyde TM, Magod P, Friedmann-Morvinski D, Madi A, Satchi-Fainaro R., Free PMC Article | 04/17/2021 |
| Biphasic Force-Regulated Phosphorylation Site Exposure and Unligation of ERM Bound with PSGL-1: A Novel Insight into PSGL-1 Signaling via Steered Molecular Dynamics Simulations. | Biphasic Force-Regulated Phosphorylation Site Exposure and Unligation of ERM Bound with PSGL-1: A Novel Insight into PSGL-1 Signaling via Steered Molecular Dynamics Simulations.
Feng J, Zhang Y, Li Q, Fang Y, Wu J., Free PMC Article | 03/6/2021 |
| The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway | The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway.
Ye Z, Zhong L, Zhu S, Wang Y, Zheng J, Wang S, Zhang J, Huang R., Free PMC Article | 07/18/2020 |
| PSGL-1 can affect the aggregation and recruitment of platelets and leukocytes, the activation of vascular endothelial cells in endotoxemic mice. PSGL-1 played an important role in pathogenesis of systemic inflammatory response syndrome and coagulation dysfunction and acute lung injury in endotoxemic mice | The role of PSGL-1 in pathogenesis of systemic inflammatory response and coagulopathy in endotoxemic mice.
Wang XL, Deng HF, Tan CY, Xiao ZH, Liu MD, Liu K, Zhang HL, Xiao XZ. | 05/2/2020 |
| platelet recruitment to lungs in response to LPS occurs through mechanisms distinct from those mediating neutrophil recruitment, or the occurrence of pulmonary emboli, which involve PSGL1 or P-selectin | LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin.
Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC., Free PMC Article | 04/11/2020 |
| Substitution V135I of VP2 enhances PSGL1 usage by adapted Enterovirus A71. | Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence.
Sun L, Tijsma A, Mirabelli C, Baggen J, Wahedi M, Franco D, De Palma A, Leyssen P, Verbeken E, van Kuppeveld FJM, Neyts J, Thibaut HJ., Free PMC Article | 11/23/2019 |
| In conclusion, hematopoietic deficiency of Psgl-1 attenuates Ang II-induced hypertension, an effect that may be mediated by reduced IL-17. | Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1.
Wang Q, Wang H, Wang J, Venugopal J, Kleiman K, Guo C, Sun Y, Eitzman DT., Free PMC Article | 09/21/2019 |
| Mice deficient in P-Selectin presented altered immunity/tolerance balance. Absence of P-Selectin promotes splenomegaly with reduced naive T cell population, elevated activated/effector T cell subset, increased germinal center B and Tfh populations and high production of autoreactive antibodies. | P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus.
González-Tajuelo R, Silván J, Pérez-Frías A, de la Fuente-Fernández M, Tejedor R, Espartero-Santos M, Vicente-Rabaneda E, Juarranz Á, Muñoz-Calleja C, Castañeda S, Gamallo C, Urzainqui A., Free PMC Article | 11/10/2018 |
| results indicate that P-selectin deletion significantly decreases tumor stiffness in Rip1-Tag2 mice by inhibiting LOX expression. | P-selectin-mediated LOX expression promotes insulinoma growth in Rip1-Tag2 mice by increasing tissue stiffness.
Qi C, Li J, Guo S, Li M, Li Y, Li J, Zhang Q, Zheng L, He X, Zheng X, He Y, Wang L, Wei B., Free PMC Article | 10/21/2017 |
| this study shows that PSGL-1 plays a fundamental role in balancing viral control and immunopathology and also functions to regulate T cell responses in the tumor microenvironment | PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.
Tinoco R, Carrette F, Barraza ML, Otero DC, Magaña J, Bosenberg MW, Swain SL, Bradley LM., Free PMC Article | 09/16/2017 |
| Psgl-1 deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT axis. | Deficiency of Psgl-1 accelerates bleomycin (BLM)-induced lung fibrosis and inflammation in mice through activating PI3K/AKT.
Han X, Wang SM. | 09/2/2017 |
| Circulating soluble P-selectin must dimerize to promote inflammation and thrombosis in mice. | Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice.
Panicker SR, Mehta-D'souza P, Zhang N, Klopocki AG, Shao B, McEver RP., Free PMC Article | 08/19/2017 |
| The results from the present study suggest that activated platelets secrete Pselectin to promote cardiac inflammation and fibrosis in Ang IIinduced hypertension. | P‑selectin increases angiotensin II‑induced cardiac inflammation and fibrosis via platelet activation.
Liu G, Liang B, Song X, Bai R, Qin W, Sun X, Lu Y, Bian Y, Xiao C., Free PMC Article | 04/8/2017 |
| These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK acts downstream from P-selectin and is necessary for the secretion of Asm. | Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets.
Becker KA, Beckmann N, Adams C, Hessler G, Kramer M, Gulbins E, Carpinteiro A. | 03/25/2017 |
| Psgl-1 deficiency is protective against the prothrombotic effects of IL-1beta . | Deficiency of P-selectin glycoprotein ligand-1 is protective against the prothrombotic effects of interleukin-1β.
Wang H, Kleiman K, Wang J, Luo W, Guo C, Eitzman DT., Free PMC Article | 11/5/2016 |