| p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence. | p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence.
Potes Y, Bermejo-Millo JC, Mendes C, Castelão-Baptista JP, Díaz-Luis A, Pérez-Martínez Z, Solano JJ, Sardão VA, Oliveira PJ, Caballero B, Coto-Montes A, Vega-Naredo I., Free PMC Article | 03/13/2024 |
| The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung. | The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung.
Castro CFG, Nardiello C, Hadzic S, Kojonazarov B, Kraut S, Gierhardt M, Schäffer J, Bednorz M, Quanz K, Heger J, Korfei M, Wilhelm J, Hecker M, Bartkuhn M, Arnhold S, Guenther A, Seeger W, Schulz R, Weissmann N, Sommer N, Pak O., Free PMC Article | 03/8/2024 |
| Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation. | Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation.
Jiang Y, Xu L, Zhu X, Zhu X, Xu X, Li J., Free PMC Article | 03/7/2024 |
| [Study of senescence protein p66[Shc] on myocardial tissue repair in adult mice]. | [Study of senescence protein p66(Shc) on myocardial tissue repair in adult mice].
Zhang Y, Huang CZ, Chen HZ, Nie Y, Hu MQ. | 01/5/2024 |
| SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc. | SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc.
Jiang T, Qin T, Gao P, Tao Z, Wang X, Wu M, Gu J, Chu B, Zheng Z, Yi J, Xu T, Huang Y, Liu H, Zhao S, Ren Y, Chen J, Yin G., Free PMC Article | 02/24/2023 |
| Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis. | Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
Yang M, Liu YT, Han YC, Zhang W, Zhang H, Yang S. | 02/13/2023 |
| USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion. | USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
Tian X, Zhao Y, Yang Z, Lu Q, Zhou L, Zheng S., Free PMC Article | 10/8/2022 |
| LONG NONCODING RNA UPREGULATES ADAPTER SHCA PROTEIN EXPRESSION TO PROMOTE COGNITIVE IMPAIRMENT AFTER CARDIAC ARREST AND RESUSCITATION. | LONG NONCODING RNA UPREGULATES ADAPTER SHCA PROTEIN EXPRESSION TO PROMOTE COGNITIVE IMPAIRMENT AFTER CARDIAC ARREST AND RESUSCITATION.
Zhang YH, Peng F, Zhang L, Kang K, Yang M, Chen C, Yu H. | 10/8/2022 |
| ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation. | ShcA promotes chondrocyte hypertrophic commitment and osteoarthritis in mice through RunX2 nuclear translocation and YAP1 inactivation.
Abou-Jaoude A, Courtes M, Badique L, Elhaj Mahmoud D, Abboud C, Mlih M, Justiniano H, Milbach M, Lambert M, Lemle A, Awan S, Terrand J, Niemeier A, Barbero A, Houard X, Boucher P, Matz RL. | 10/8/2022 |
| Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone. | Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone.
Gierhardt M, Pak O, Sydykov A, Kraut S, Schäffer J, Garcia C, Veith C, Zeidan EM, Brosien M, Quanz K, Esfandiary A, Saraji A, Hadzic S, Kojonazarov B, Wilhelm J, Ghofrani HA, Schermuly RT, Seeger W, Grimminger F, Herden C, Schulz R, Weissmann N, Heger J, Sommer N., Free PMC Article | 03/12/2022 |
| Protective Effects of ShcA Protein Silencing for Photothrombotic Cerebral Infarction. | Protective Effects of ShcA Protein Silencing for Photothrombotic Cerebral Infarction.
Hwang JA, Shin N, Shin HJ, Yin Y, Kwon HH, Park H, Shin J, Kim SI, Kim DW, Song HJ. | 01/22/2022 |
| P66Shc Deletion Ameliorates Oxidative Stress and Cardiac Dysfunction in Pressure Overload-Induced Heart Failure. | P66Shc Deletion Ameliorates Oxidative Stress and Cardiac Dysfunction in Pressure Overload-Induced Heart Failure.
Wang Y, Qu H, Liu J. | 09/18/2021 |
| circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion. | circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion.
Feng D, Wang Z, Zhao Y, Li Y, Liu D, Chen Z, Ning S, Hu Y, Yao J, Tian X., Free PMC Article | 06/5/2021 |
| Piperazine ferulate attenuates high glucoseinduced mesangial cell injury via the regulation of p66(Shc). | Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66(Shc).
Yang YY, Deng RR, Chen Z, Yao LY, Yang XD, Xiang DX., Free PMC Article | 05/15/2021 |
| Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy. | Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy.
Hirschhäuser C, Sydykov A, Wolf A, Esfandiary A, Bornbaum J, Kutsche HS, Boengler K, Sommer N, Schreckenberg R, Schlüter KD, Weissmann N, Schermuly R, Schulz R., Free PMC Article | 03/6/2021 |
| The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation. | The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.
Kiepas A, Voorand E, Senecal J, Ahn R, Annis MG, Jacquet K, Tali G, Bisson N, Ursini-Siegel J, Siegel PM, Brown CM., Free PMC Article | 01/16/2021 |
| Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity. | Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.
Costantino S, Paneni F, Virdis A, Hussain S, Mohammed SA, Capretti G, Akhmedov A, Dalgaard K, Chiandotto S, Pospisilik JA, Jenuwein T, Giorgio M, Volpe M, Taddei S, Lüscher TF, Cosentino F. | 09/5/2020 |
| Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor. | Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor.
Persson E, Souza PPC, Floriano-Marcelino T, Conaway HH, Henning P, Lerner UH., Free PMC Article | 08/22/2020 |
| results highlight p66Shc deficiency as an important factor in the progression and severity of chronic lymphocytic leukemia and underscore p66Shc expression as a relevant therapeutic target. | p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape.
Patrussi L, Capitani N, Ulivieri C, Manganaro N, Granai M, Cattaneo F, Kabanova A, Mundo L, Gobessi S, Frezzato F, Visentin A, Finetti F, Pelicci PG, D'Elios MM, Trentin L, Semenzato G, Leoncini L, Efremov DG, Baldari CT., Free PMC Article | 07/11/2020 |
| Klotho might inhibit PKCalpha/p66SHC-mediated podocyte injury in diabetic nephropathy. | Klotho inhibits PKCα/p66SHC-mediated podocyte injury in diabetic nephropathy.
Jiang W, Xiao T, Han W, Xiong J, He T, Liu Y, Huang Y, Yang K, Bi X, Xu X, Yu Y, Li Y, Gu J, Zhang J, Huang Y, Zhang B, Zhao J. | 05/30/2020 |
| Perturbations in the rhythm of H2O2 levels induced by the loss of p66(Shc). | Diurnal oscillations of endogenous H(2)O(2) sustained by p66(Shc) regulate circadian clocks.
Pei JF, Li XK, Li WQ, Gao Q, Zhang Y, Wang XM, Fu JQ, Cui SS, Qu JH, Zhao X, Hao DL, Ju D, Liu N, Carroll KS, Yang J, Zhang EE, Cao JM, Chen HZ, Liu DP., Free PMC Article | 02/15/2020 |
| p66Shc is a key regulator of liver fibrosis by mediating mitochondrial reactive oxygen species production, which triggers NLRP3 inflammasome activation. | p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Zhao Y, Wang Z, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J., Free PMC Article | 02/1/2020 |
| these data indicate that cell-autonomous activation of the OSM-p66Shc pathway leads to diabetes-associated myelopoiesis, whereas its transcellular hematostromal activation links myelopoiesis to mobilopathy. | Diabetes-Associated Myelopoiesis Drives Stem Cell Mobilopathy Through an OSM-p66Shc Signaling Pathway.
Albiero M, Ciciliot S, Tedesco S, Menegazzo L, D'Anna M, Scattolini V, Cappellari R, Zuccolotto G, Rosato A, Cignarella A, Giorgio M, Avogaro A, Fadini GP. | 12/28/2019 |
| This study postulates a p66Shc-mediated inflammatory cascade leading to oxidative stress as a causative pathogenic mechanism in diabetes-associated cognitive impairment that is at least partially mediated through an AD-pathology-independent mechanism. | p66Shc Signaling Mediates Diabetes-Related Cognitive Decline.
Minami Y, Sonoda N, Hayashida E, Makimura H, Ide M, Ikeda N, Ohgidani M, Kato TA, Seki Y, Maeda Y, Kanba S, Takayanagi R, Ogawa Y, Inoguchi T., Free PMC Article | 10/19/2019 |
| These results suggest that p66Shc may regulate the relative abundance and timing of lineage-associated transcription factor expression in the blastocyst inner cell mass . | Knockdown of p66Shc Alters Lineage-Associated Transcription Factor Expression in Mouse Blastocysts.
Edwards NA, Watson AJ, Betts DH., Free PMC Article | 10/5/2019 |