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    St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 20450, updated on 23-Jun-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency.

    Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency.
    Bacq A, Astori S, Gebara E, Tang W, Silva BA, Sanchez-Mut J, Grosse J, Guillot de Suduiraut I, Zanoletti O, Maclachlan C, Knott GW, Gräff J, Sandi C., Free PMC Article

    06/12/2021
    Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.

    Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.
    Ikegami K, Saigoh K, Fujioka A, Nagano M, Kitajima K, Sato C, Masubuchi S, Kusunoki S, Shigeyoshi Y., Free PMC Article

    10/31/2020
    the data demonstrate a cell-autonomous impact of ST8SIA2 on cortical interneuron migration and the distribution of parvalbumin-positive interneurons in the anterior cortex

    Cell-autonomous impact of polysialic acid-producing enzyme ST8SIA2 on developmental migration and distribution of cortical interneurons.
    Schuster UE, Rossdam C, Röckle I, Schiff M, Hildebrandt H.

    07/4/2020
    Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4

    Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice.
    Röckle I, Hildebrandt H.

    12/17/2016
    NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX enhanced NCAM-mediated cell migration, but not cell proliferation or motility.

    Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner.
    Guan F, Wang X, He F., Free PMC Article

    04/16/2016
    These results reveal that reduced polysialylation in St8sia2 (-/-) mice leads to pathological brain development and schizophrenia-like behavior.

    Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
    Kröcher T, Malinovskaja K, Jürgenson M, Aonurm-Helm A, Zharkovskaya T, Kalda A, Röckle I, Schiff M, Weinhold B, Gerardy-Schahn R, Hildebrandt H, Zharkovsky A.

    08/29/2015
    This study demonstrated that St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.

    St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
    Tantra M, Kröcher T, Papiol S, Winkler D, Röckle I, Jatho J, Burkhardt H, Ronnenberg A, Gerardy-Schahn R, Ehrenreich H, Hildebrandt H.

    07/25/2015
    Results indicate that the polySTs ST8SiaII and ST8SiaIV not only recognize an acidic patch in the FN1 domain of NCAM but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.

    The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.
    Thompson MG, Foley DA, Colley KJ., Free PMC Article

    05/4/2013
    Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo.

    Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo.
    Rollenhagen M, Kuckuck S, Ulm C, Hartmann M, Galuska SP, Geyer R, Geyer H, Mühlenhoff M., Free PMC Article

    01/5/2013
    results suggest that the ST8Sia5 gene increases ganglioside GQ1b and improves neuronal differentiation via the ERK1/2 MAP kinase pathway

    Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells.
    Kwak DH, Jin JW, Ryu JS, Ko K, Lee SD, Lee JW, Kim JS, Jung KY, Ko K, Ma JY, Hwang KA, Chang KT, Choo YK.

    07/14/2012
    While both ST8SiaII and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII mRNA level reduction is regulated by sensory experience

    Sensory experience differentially modulates the mRNA expression of the polysialyltransferases ST8SiaII and ST8SiaIV in postnatal mouse visual cortex.
    Bélanger MC, Di Cristo G., Free PMC Article

    02/4/2012
    At the mRNA level, the expression of GAD67 and of St8SiaII was significantly reduced by chronic stress in the amygdala of adult mice.

    Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice.
    Gilabert-Juan J, Castillo-Gomez E, Pérez-Rando M, Moltó MD, Nacher J.

    12/10/2011
    ST8sia2 knockout mice displayed both decreased social motivation and increased aggressive behavior not explained by olfactory deficits. They displayed reduced anxiety-like behavior, increased locomotion and stress-induced corticosterone secretion.

    Differential impact of polysialyltransferase ST8SiaII and ST8SiaIV knockout on social interaction and aggression.
    Calandreau L, Márquez C, Bisaz R, Fantin M, Sandi C.

    03/5/2011
    ST8SiaII is the major polysialyltransferase in immature neurons of the paleocortex layer II and the hippocampal subgranular zone.

    Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex.
    Nacher J, Guirado R, Varea E, Alonso-Llosa G, Röckle I, Hildebrandt H.

    07/5/2010
    Data show that ST8sia2 is expressed only in the neonatal atrium and action potential is altered consistently in ST8sia2((-/-)) atrial myocytes.

    Regulated and aberrant glycosylation modulate cardiac electrical signaling.
    Montpetit ML, Stocker PJ, Schwetz TA, Harper JM, Norring SA, Schaffer L, North SJ, Jang-Lee J, Gilmartin T, Head SR, Haslam SM, Dell A, Marth JD, Bennett ES., Free PMC Article

    01/21/2010
    The developmental changes in neural cell adhesion molecule polysialylation in wild-type, ST8SiaII-, and ST8SiaIV-deficient mice from postnatal days 1 to 21 and from adult mice, was monitored.

    Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development.
    Oltmann-Norden I, Galuska SP, Hildebrandt H, Geyer R, Gerardy-Schahn R, Geyer H, Mühlenhoff M.

    01/21/2010
    the coordinated action of ST8SiaII and ST8SiaIV is crucial to fine-tune the amount and structure of polySia on NCAM

    Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV.
    Galuska SP, Oltmann-Norden I, Geyer H, Weinhold B, Kuchelmeister K, Hildebrandt H, Gerardy-Schahn R, Geyer R, Mühlenhoff M.

    01/21/2010
    Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior

    Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior.
    Angata K, Long JM, Bukalo O, Lee W, Dityatev A, Wynshaw-Boris A, Schachner M, Fukuda M, Marth JD.

    01/21/2010
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