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    Slc34a1 solute carrier family 34 (sodium phosphate), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20505, updated on 16-Oct-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Cre/loxP approach-mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells.

    Cre/loxP approach-mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells.
    Liu T, Yuan J, Dai C, Xu J, Li S, Humphreys BD, Kleven DT, Chen JK.,

    04/3/2021
    Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion.

    Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion.
    Clerin V, Saito H, Filipski KJ, Nguyen AH, Garren J, Kisucka J, Reyes M, Jüppner H., Free PMC Article

    02/20/2021
    Nampt/NAD(+) system for Npt2 regulation and cellular shifts to tissues such as the liver play an important role in generating daily oscillation of plasma inorganic phosphate levels.

    The sodium phosphate cotransporter family and nicotinamide phosphoribosyltransferase contribute to the daily oscillation of plasma inorganic phosphate concentration.
    Miyagawa A, Tatsumi S, Takahama W, Fujii O, Nagamoto K, Kinoshita E, Nomura K, Ikuta K, Fujii T, Hanazaki A, Kaneko I, Segawa H, Miyamoto KI.

    12/22/2018
    Results show that urine pyrophosphate (PPI) levels are increased in Npt2a-/- mice when compared to WT, possibly to protect from renal mineralization in the setting of hyperphosphaturia. However, the presence of two hypomorphic Enpp1asj/asj alleles decreases urine PPi and worsens renal calcium phosphate deposit formation in Npt2a-/- mice.

    Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice.
    Caballero D, Li Y, Fetene J, Ponsetto J, Chen A, Zhu C, Braddock DT, Bergwitz C., Free PMC Article

    09/23/2017
    Npt2a-/- mice respond differently to dietary phosphate when compared to WT mice

    Response of Npt2a knockout mice to dietary calcium and phosphorus.
    Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C., Free PMC Article

    09/9/2017
    observed a marked decrease of renal gene expression and urinary excretion of osteopontin in Npt2a(-/-) mice

    Impaired urinary osteopontin excretion in Npt2a-/- mice.
    Caballero D, Li Y, Ponsetto J, Zhu C, Bergwitz C., Free PMC Article

    09/9/2017
    Analysis of calcium and phosphate metabolism in Slc34a1-knockout mice highlighted the effect of phosphate depletion and fibroblast growth factor-23 suppression on the development of the idiopathic infantile hypercalcemia phenotype.

    Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia.
    Schlingmann KP, Ruminska J, Kaufmann M, Dursun I, Patti M, Kranz B, Pronicka E, Ciara E, Akcay T, Bulus D, Cornelissen EA, Gawlik A, Sikora P, Patzer L, Galiano M, Boyadzhiev V, Dumic M, Vivante A, Kleta R, Dekel B, Levtchenko E, Bindels RJ, Rust S, Forster IC, Hernando N, Jones G, Wagner CA, Konrad M., Free PMC Article

    07/30/2016
    AC6 in the proximal tubule modulates cAMP formation, Npt2a trafficking, and urinary phosphate excretion, which are highlighted by renal phosphate wasting in AC6(-/-) mice

    Renal phosphate wasting in the absence of adenylyl cyclase 6.
    Fenton RA, Murray F, Dominguez Rieg JA, Tang T, Levi M, Rieg T., Free PMC Article

    02/28/2015
    Downregulation of renal Npt2a expression through induction of plasma iPTH levels alters Pi homeostasis during LPS-induced acute inflammation.

    Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation.
    Ikeda S, Yamamoto H, Masuda M, Takei Y, Nakahashi O, Kozai M, Tanaka S, Nakao M, Taketani Y, Segawa H, Iwano M, Miyamoto K, Takeda E.

    05/31/2014
    serine 249 of ezrin can play important roles in the regulation of the complex formation and membrane localization of NaPi-IIa.

    Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells.
    Yamada F, Horie D, Nakamura A, Tanimura A, Yamamoto H, Segawa H, Ito M, Miyamoto K, Taketani Y, Takeda E.

    01/18/2014
    Npt2a protein expression in PTH-D1 mice was decreased relative to control animals, whereas levels of Na-K, NHERF-1, and PTH receptor remained unchanged.

    Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability.
    Murray RD, Holthouser K, Clark BJ, Salyer SA, Barati MT, Khundmiri SJ, Lederer ED.

    06/15/2013
    The authors conclude that the polyclonal antiserum is specific toward NaPi-IIa in the kidney, but in the brain, immunolabeling is caused by a cross-reaction of the antiserum with an unknown cytosolic protein that is not present in the kidney.

    The sodium-dependent inorganic phosphate transporter SLC34A1 (NaPi-IIa) is not localized in the mouse brain: a case of tissue-specific antigenic cross-reactivity.
    Larsson M, Morland C, Poblete-Naredo I, Biber J, Danbolt NC, Gundersen V., Free PMC Article

    10/15/2011
    reduced intestinal Pi absorption in VDR (-/-) mice does not seem to be the only factor that causes hypophosphatemia; reduced Npt2a, Npt2c, or PiT-2 protein levels during development might also cause hypophosphatemia and rickets in VDR (-/-) mice.

    Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters.
    Kaneko I, Segawa H, Furutani J, Kuwahara S, Aranami F, Hanabusa E, Tominaga R, Giral H, Caldas Y, Levi M, Kato S, Miyamoto K.

    06/25/2011
    acute down-regulation of NPT2a expression by PTH ligands involves mainly the cAMP/PKA signaling pathway and are thus consistent with the elevated blood P(i) levels seen in pseudohypoparathyroidism

    Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs.
    Nagai S, Okazaki M, Segawa H, Bergwitz C, Dean T, Potts JT Jr, Mahon MJ, Gardella TJ, Jüppner H., Free PMC Article

    03/5/2011
    The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for maintenance of a normal growth plate phenotype in the Npt2a null mice.

    The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal growth plate maturation in NPt2a knockout mice.
    Miedlich SU, Zhu ED, Sabbagh Y, Demay MB., Free PMC Article

    11/6/2010
    In GABARAP-deficient mice renal NaPi-IIa is up-regulation and intestinal NaPi-IIb is downregulated.

    Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.
    Reining SC, Liesegang A, Betz H, Biber J, Murer H, Hernando N.

    08/30/2010
    Findings suggest that Npt2a, Npt2c, and PiT-2 are necessary for the phosphaturic activity of FGF23.

    Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.
    Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami F, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto K.

    06/28/2010
    the loss of NaPiT2a is a reliable marker for predicting the progression of septic ARF, while local hypoxia might be involved in the decrease of NaPiT2a expression.

    Type 2a sodium-phosphate co-transporter serves as a histological predictor of renal dysfunction and tubular apical damage in the kidneys of septic mice.
    Kamimoto M, Mizuno S, Ohnishi H, Mizuno-Horikawa Y.

    01/21/2010
    Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.

    Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.
    Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K.

    01/21/2010
    FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.

    FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
    Gattineni J, Bates C, Twombley K, Dwarakanath V, Robinson ML, Goetz R, Mohammadi M, Baum M., Free PMC Article

    01/21/2010
    Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.

    Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
    Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander JW, Wilson P, Miyazaki-Anzai S, Sutherland E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M., Free PMC Article

    01/21/2010
    The expression of Na(+)/H(+) exchanger regulatory factor (NHERF)1, an important scaffold for the apical expression of NaPi-IIa, is also increased in GABARAP(-/-) mice

    GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes.
    Reining SC, Gisler SM, Fuster D, Moe OW, O'Sullivan GA, Betz H, Biber J, Murer H, Hernando N., Free PMC Article

    01/21/2010
    The antisense transcript from the Na/phosphate transporter gene Slc34a1 is prominently found in testis and in kidney.

    Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissues.
    Carlile M, Swan D, Jackson K, Preston-Fayers K, Ballester B, Flicek P, Werner A., Free PMC Article

    01/21/2010
    Npt2a knockout mice are hypercalciuric and produce calcium phosphate deposits in their renal tubules

    Calcium oxalate crystal deposition in kidneys of hypercalciuric mice with disrupted type IIa sodium-phosphate cotransporter.
    Khan SR, Glenton PA., Free PMC Article

    01/21/2010
    FGF23 transgenic mice display differentially expressed transcript levels of several genes (Npt2a, Pdzk1, Atp1a2) essential in renal Pi regulation.

    Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23.
    Marsell R, Krajisnik T, Göransson H, Ohlsson C, Ljunggren O, Larsson TE, Jonsson KB.

    01/21/2010
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