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    Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20510, updated on 6-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The role of diurnal fluctuations in excitatory amino acid carrier 1 levels in post-ischemic hippocampal Zn(2+) accumulation.

    The role of diurnal fluctuations in excitatory amino acid carrier 1 levels in post-ischemic hippocampal Zn<sup>2+</sup> accumulation.
    Aratake T, Higashi Y, Hamada T, Ueba Y, Shimizu T, Shimizu S, Yawata T, Ueba T, Saito M.

    09/4/2021
    Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice.

    Neuregulin-1 inhibits CoCl<sub>2</sub>-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice.
    Kim HB, Yoo JY, Yoo SY, Lee JH, Chang W, Kim HS, Baik TK, Woo RS., Free PMC Article

    08/7/2021
    Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc(-) for Glutathione Synthesis in Lung Cancer.

    Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc<sup>-</sup> for Glutathione Synthesis in Lung Cancer.
    Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, Lin SH, Deng J.

    05/1/2021
    EAAC1 is important for the survival of newly generated neurons in the adult brain under physiological and pathological conditions. Therefore, this study suggests that EAAC1 plays an essential role in modulating hippocampal neurogenesis.

    EAAC1 gene deletion reduces adult hippocampal neurogenesis after transient cerebral ischemia.
    Choi BY, Won SJ, Kim JH, Sohn M, Song HK, Chung TN, Kim TY, Suh SW., Free PMC Article

    10/19/2019
    This study found high EAAT3 protein levels in the brush borders of both the distal small intestine and the renal proximal tubules.

    Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine.
    Hu QX, Ottestad-Hansen S, Holmseth S, Hassel B, Danbolt NC, Zhou Y., Free PMC Article

    08/3/2019
    Here is reported a model of Slc1a1 loss based on an excisable STOP cassette that yields successful ablation of EAAT3 expression and function. EAAT3 loss prevents expected increases in (i) locomotor activity, (ii) stereotypy, and (iii) immediate early gene induction in the dorsal striatum following amphetamine administration.

    OCD candidate gene <i>SLC1A1</i>/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
    Zike ID, Chohan MO, Kopelman JM, Krasnow EN, Flicker D, Nautiyal KM, Bubser M, Kellendonk C, Jones CK, Stanwood G, Tanaka KF, Moore H, Ahmari SE, Veenstra-VanderWeele J., Free PMC Article

    05/19/2018
    Morphine increased EAAT3 expression in the plasma membrane of medial prefrontal cortex, nucleus accumbens and ventral tegmental area but did not affect EAAT3 expression in the hippocampus. Results also suggest that EAAT3 delays the extinction of morphine-induced conditioned place preference (CPP). EAAT activation may prevent the formation of morphine-induced CPP.

    Glutamate transporter type 3 participates in maintaining morphine-induced conditioned place preference.
    Wan L, Bi J, Li J, Zuo Z., Free PMC Article

    11/11/2017
    partial loss of the Slc1a1 gene in mice causes haploinsufficiency associated with behavioral, histological and biochemical changes that reflect an altered redox state and may promote the expression of behavioral features and inflammatory states consistent with those observed in schizophrenia.

    Reduced Slc1a1 expression is associated with neuroinflammation and impaired sensorimotor gating and cognitive performance in mice: Implications for schizophrenia.
    Afshari P, Yao WD, Middleton FA., Free PMC Article

    11/4/2017
    this paper shows increased EAAC1 protein expression in lysates from livers of NOD mice compared with B6 mice

    Elevated systemic glutamic acid level in the non-obese diabetic mouse is Idd linked and induces beta cell apoptosis.
    Banday VS, Lejon K., Free PMC Article

    05/20/2017
    These findings suggest that cysteine uptake by EAAC1 is important for neuronal antioxidant function under ischemic conditions.

    EAAC1 gene deletion increases neuronal death and blood brain barrier disruption after transient cerebral ischemia in female mice.
    Choi BY, Kim JH, Kim HJ, Lee BE, Kim IY, Sohn M, Suh SW., Free PMC Article

    06/27/2015
    these studies indicate that absence of EAAC1 results in either a decrease in pilocarpine-induced seizures that is not detectable by behavioral criteria

    Genetic deletion of the neuronal glutamate transporter, EAAC1, results in decreased neuronal death after pilocarpine-induced status epilepticus.
    Lane MC, Jackson JG, Krizman EN, Rothstein JD, Porter BE, Robinson MB., Free PMC Article

    02/7/2015
    EAAT3 is upstream of PKA in a pathway to regulate GluR1 trafficking.

    Glutamate transporter type 3 regulates mouse hippocampal GluR1 trafficking.
    Cao J, Tan H, Mi W, Zuo Z., Free PMC Article

    07/5/2014
    EAAT3/EAAC1 expression is altered in murine models of human neurodegenerative diseases. (Review)

    Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease.
    Bianchi MG, Bardelli D, Chiu M, Bussolati O.

    06/28/2014
    These results suggest that the isoflurane preconditioning-induced acute phase of neuroprotection involves EAAT3.

    Glutamate transporter type 3 mediates isoflurane preconditioning-induced acute phase of neuroprotection in mice.
    Li L, Deng J, Zuo Z., Free PMC Article

    05/31/2014
    These findings indicate that regulation of heart rate, a vital sign, is one of the EAAT biological functions.

    Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism.
    Deng J, Li J, Li L, Feng C, Xiong L, Zuo Z., Free PMC Article

    03/22/2014
    Study implicates EAAC1-dependent cysteine uptake as an endogenous source of enhancing antioxidant function and zinc homeostasis in neurons in the ischemic brain.

    EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice.
    Jang BG, Won SJ, Kim JH, Choi BY, Lee MW, Sohn M, Song HK, Suh SW.

    10/20/2012
    This study showed that these relatively small amounts of EAAC1 protein are widely distributed in somata and dendrites of all hippocampal neurons.

    The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS.
    Holmseth S, Dehnes Y, Huang YH, Follin-Arbelet VV, Grutle NJ, Mylonakou MN, Plachez C, Zhou Y, Furness DN, Bergles DE, Lehre KP, Danbolt NC., Free PMC Article

    06/30/2012
    These findings identify a mechanism whereby Nrf2 activation can coordinate astrocyte glutathione release with neuronal glutathione synthesis through transcriptional upregulation of neuronal EAAT3 expression.

    Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression.
    Escartin C, Won SJ, Malgorn C, Auregan G, Berman AE, Chen PC, Déglon N, Johnson JA, Suh SW, Swanson RA., Free PMC Article

    07/23/2011
    EAAT3 is important in limiting ischemic brain injury after focal brain ischemia

    Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice.
    Li L, Zuo Z., Free PMC Article

    07/2/2011
    GLAST, GLT1 and EAAC1 are needed to clear neurotransmitter from the synapse after intense acoustic stimulation, and to protect the cochlea from exposure to glutamate present in the extracellular space

    Functional roles of high-affinity glutamate transporters in cochlear afferent synaptic transmission in the mouse.
    Chen Z, Kujawa SG, Sewell WF., Free PMC Article

    08/30/2010
    Rab11 dysfunction slows trafficking of EAAC1 to the cell surface and impairs cysteine uptake, thereby leading to deficient synthesis of glutathione.

    Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
    Li X, Valencia A, Sapp E, Masso N, Alexander J, Reeves P, Kegel KB, Aronin N, Difiglia M., Free PMC Article

    05/3/2010
    Our findings suggest that the use of IL-1 for enhancing the function of glutamate transporters (EAAC1, but not GLAST) may be useful for neuroprotection in retinal degenerative disorders including normal tension glaucoma.

    Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice.
    Namekata K, Harada C, Guo X, Kikushima K, Kimura A, Fuse N, Mitamura Y, Kohyama K, Matsumoto Y, Tanaka K, Harada T.

    01/21/2010
    EAAC1 buffers glutamate release during synaptic events and prolongs the time course of its clearance by astrocytes.

    Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus.
    Scimemi A, Tian H, Diamond JS., Free PMC Article

    01/21/2010
    The findings suggest that protein kinase C (PKC) is involved in regulation of surface trafficking of GLT1 and EAAC1 and that PKC stimulated increase in surface location of GLT1 and EAAC1 in glutamatergic cerebellar granule cells.

    Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells.
    Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P.

    01/21/2010
    stimulation of EAAC1-mediated glutamate transport by thapsigargin is dependent on entry of calcium via the NSCC-1 subtype of store operated calcium channel and is mediated by protein kinase C

    Stimulation of EAAC1 in C6 glioma cells by store-operated calcium influx.
    Murphy A, Vines A, McBean GJ.

    01/21/2010
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