| Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin. | Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin.
Hucke A, Schröter R, Ceresa C, Chiorazzi A, Canta A, Semperboni S, Marmiroli P, Cavaletti G, Gess B, Ciarimboli G., Free PMC Article | 08/19/2023 |
| Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1. | Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1.
Meyer MJ, Schreier PCF, Basaran M, Vlasova S, Seitz T, Brockmöller J, Zdrazil B, Tzvetkov MV., Free PMC Article | 07/2/2022 |
| Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families. | Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Gorecki M, Müller SF, Leidolf R, Geyer J., Free PMC Article | 04/3/2021 |
| Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction. | Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
Floerl S, Kuehne A, Hagos Y., Free PMC Article | 02/27/2021 |
| OCT1 modulates multiple cardiometabolic traits through effects on hepatic thiamine content. | Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM., Free PMC Article | 03/30/2019 |
| we unraveled substrate affinities and modulation of transport activity by acute regulation by protein kinases on mOCT1 and mOCT2 | Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.
Schlatter E, Klassen P, Massmann V, Holle SK, Guckel D, Edemir B, Pavenstädt H, Ciarimboli G. | 02/28/2015 |
| Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours. | Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Yang J, Kalogerou M, Gallacher J, Sampson JR, Shen MH. | 06/1/2013 |
| Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen. | Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca²⁺-dependent Cl⁻ and K⁺ channels.
Hollenhorst MI, Lips KS, Wolff M, Wess J, Gerbig S, Takats Z, Kummer W, Fronius M., Free PMC Article | 10/13/2012 |
| The influence of organic cation transporters 1, 2, and 3 (OCT1, OCT2, and OCT3) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined. | Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.
More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM., Free PMC Article | 07/12/2010 |
| the interaction of glucocorticoid receptor with Oct-1 on the beta-casein gene promoter | Oct-1 functions as a transactivator in the hormonal induction of beta-casein gene expression.
Dong B, Huang C, Li D, Zhao FQ. | 01/21/2010 |
| Effect of OCT1 genotype on metformin pharmacokinetics in mice was less than in humans. | Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM., Free PMC Article | 01/21/2010 |
| Genetic variation in OCT1 may contribute to variation in individual response to the drug. | Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM., Free PMC Article | 01/21/2010 |
| The purpose of this study was to examine the effects of peroxisome proliferator agonist receptor agonists on the hepatic regulation and function of Slc22a1. | Transcriptional regulation of murine Slc22a1 (Oct1) by peroxisome proliferator agonist receptor-alpha and -gamma.
Nie W, Sweetser S, Rinella M, Green RM. | 01/21/2010 |
| Oct-1 has an important role in IFN-A regulation | The POU transcription factor Oct-1 represses virus-induced interferon A gene expression.
Mesplède T, Island ML, Christeff N, Petek F, Doly J, Navarro S., Free PMC Article | 01/21/2010 |
| Doubling of airway epithelial acetylcholine (ACh) in OCT1/2-/- mice is consistent with OCT1 and/or 2 mediating ACh release from respiratory epithelium. This effect does not contribute to 5-HT-induced constriction of murine intrapulmonary bronchi. | Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse.
Kummer W, Wiegand S, Akinci S, Wessler I, Schinkel AH, Wess J, Koepsell H, Haberberger RV, Lips KS., Free PMC Article | 01/21/2010 |
| The ubiquitous Oct-1 transcription factor may be involved in hormonally regulated, tissue-specific beta-casein gene expression. | Involvement of the ubiquitous Oct-1 transcription factor in hormonal induction of beta-casein gene expression.
Dong B, Zhao FQ., Free PMC Article | 01/21/2010 |
| Real-time RT-PCR revealed significant decreases in OCT1 mRNA in the lung of sensitized and allergen challenged animals. | Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse.
Lips KS, Lührmann A, Tschernig T, Stoeger T, Alessandrini F, Grau V, Haberberger RV, Koepsell H, Pabst R, Kummer W. | 01/21/2010 |
| Oct1 forms repeating, cyclosporin-sensitive regulatory modules within the CD21 intronic control region. | Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region.
Zabel MD, Wheeler W, Weis JJ, Weis JH. | 01/21/2010 |
| a comparison of the transport properties of Oct2 and Oct1 | Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.
Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y. | 01/21/2010 |
| oct1 has a role in controlling fgl2 expression in endothelial cells | Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3.
Liu M, Leibowitz JL, Clark DA, Mendicino M, Ning Q, Ding JW, D'Abreo C, Fung L, Marsden PA, Levy GA. | 01/21/2010 |
| nuclear factor Y and Oct-1 bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated expression of the mGnRH receptor gene | Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription.
Kam KY, Jeong KH, Norwitz ER, Jorgensen EM, Kaiser UB. | 01/21/2010 |
| rOCT1 could transport the nucleoside analog deoxytubercidin | Renal organic cation and nucleoside transport.
Chen R, Jonker JW, Nelson JA. | 01/21/2010 |
| This study shows that Oct1 and Oct2 together are essential for renal secretion of (small) organic cations. | Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.
Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH., Free PMC Article | 01/21/2010 |
| a multiprotein complex containing GATA-1, Oct-1, and other protein factors may contribute to the formation of a repressive chromatin structure that silences gamma-globin gene expression | T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice.
Liu LR, Du ZW, Zhao HL, Liu XL, Huang XD, Shen J, Ju LM, Fang FD, Zhang JW. | 01/21/2010 |
| Involvement in hepatic and intestinal distribution of metformin. | Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y. | 01/21/2010 |