| Involvement of sodium-glucose cotransporter-1 activities in maintaining oscillatory Cl[-] currents from mouse submandibular acinar cells. | Involvement of sodium-glucose cotransporter-1 activities in maintaining oscillatory Cl(-) currents from mouse submandibular acinar cells.
Takeyasu M, Kozai K, Sugita M., Free PMC Article | 03/19/2024 |
| Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1) impairs mouse sperm movement. | Deletion of the Sodium Glucose Cotransporter 1 (Sglt-1) impairs mouse sperm movement.
Numata S, Oishee MJ, McDermott J, Koepsell H, Vallon V, Blanco G. | 03/1/2024 |
| Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection. | Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection.
Peritore-Galve FC, Kaji I, Smith A, Walker LM, Shupe JA, Washington MK, Algood HMS, Dudeja PK, Goldenring JR, Lacy DB., Free PMC Article | 06/28/2023 |
| The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertilitydagger. | The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility†.
Numata S, McDermott JP, Sanchez G, Mitra A, Blanco G., Free PMC Article | 06/25/2022 |
| Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine. | Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine.
Nishimura K, Fujita Y, Ida S, Yanagimachi T, Ohashi N, Nishi K, Nishida A, Iwasaki Y, Morino K, Ugi S, Nishi E, Andoh A, Maegawa H., Free PMC Article | 04/30/2022 |
| Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration. | Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration.
Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R., Free PMC Article | 03/19/2022 |
| Inhibition of SGLT1 Alleviates the Glycemic Variability-Induced Cardiac Fibrosis via Inhibition of Activation of Macrophage and Cardiac Fibroblasts. | Inhibition of SGLT1 Alleviates the Glycemic Variability-Induced Cardiac Fibrosis via Inhibition of Activation of Macrophage and Cardiac Fibroblasts.
Wu W, Chai Q, Zhang Z., Free PMC Article | 03/5/2022 |
| Expression of SGLT1 in the Mouse Endometrial Epithelium and its Role in Early Embryonic Development and Implantation. | Expression of SGLT1 in the Mouse Endometrial Epithelium and its Role in Early Embryonic Development and Implantation.
Zhang LX, Song JW, Ma YD, Wang YC, Cui ZH, Long Y, Yuan DZ, Zhang JH, Hu Y, Yu LL, Nie L, Yue LM. | 03/5/2022 |
| Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1). | Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1).
Wu W, Chai Q, Zhang Z. | 10/2/2021 |
| SGLT1 participates in the development of vascular cognitive impairment in a mouse model of small vessel disease. | SGLT1 participates in the development of vascular cognitive impairment in a mouse model of small vessel disease.
Ishida N, Saito M, Sato S, Koepsell H, Taira E, Hirose M. | 04/24/2021 |
| New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans. | New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans.
Ferté L, Marino A, Battault S, Bultot L, Van Steenbergen A, Bol A, Cumps J, Ginion A, Koepsell H, Dumoutier L, Hue L, Horman S, Bertrand L, Beauloye C., Free PMC Article | 03/28/2021 |
| Inhibition of SGLT1 protects against glycemic variability-induced cardiac damage and pyroptosis of cardiomyocytes in diabetic mice. | Inhibition of SGLT1 protects against glycemic variability-induced cardiac damage and pyroptosis of cardiomyocytes in diabetic mice.
Sun Z, Chai Q, Zhang Z, Lu D, Meng Z, Wu W. | 03/20/2021 |
| HNF1alpha controls glucagon secretion in pancreatic alpha-cells through modulation of SGLT1. | HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1.
Sato Y, Rahman MM, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez FJ, Yamamura KI, Yamagata K., Free PMC Article | 12/12/2020 |
| During myocardial ischaemia, AMPK up-regulates SGLT1 through ERK, and SGLT1 interacts with EGFR, which in turn increases PKC and Nox2 activity and oxidative stress in cardiac myocytes. | Cardiac sodium-dependent glucose cotransporter 1 is a novel mediator of ischaemia/reperfusion injury.
Li Z, Agrawal V, Ramratnam M, Sharma RK, D'Auria S, Sincoular A, Jakubiak M, Music ML, Kutschke WJ, Huang XN, Gifford L, Ahmad F., Free PMC Article | 06/20/2020 |
| SGLT1 contributes to diabetic hyperfiltration and limits diabetic hypertension. Glucose-driven upregulation of macula densa-NOS1 expression increases GFR to maintain volume balance when enhanced MD glucose delivery indicates upstream saturation of SGLTs and thus hyperreabsorption. | Knockout of Na(+)-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration.
Song P, Huang W, Onishi A, Patel R, Kim YC, van Ginkel C, Fu Y, Freeman B, Koepsell H, Thomson S, Liu R, Vallon V., Free PMC Article | 03/21/2020 |
| SGLT1 activity in the late proximal tubule may have deleterious effects during recovery of ischemia reperfusion-induced acute kidney injury. | Gene deletion of the Na(+)-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion.
Nespoux J, Patel R, Hudkins KL, Huang W, Freeman B, Kim YC, Koepsell H, Alpers CE, Vallon V., Free PMC Article | 02/1/2020 |
| Data suggested that a novel mechanism regulated glucagon secretion through SGLT1 in alpha cells. | SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels.
Suga T, Kikuchi O, Kobayashi M, Matsui S, Yokota-Hashimoto H, Wada E, Kohno D, Sasaki T, Takeuchi K, Kakizaki S, Yamada M, Kitamura T., Free PMC Article | 01/11/2020 |
| These results indicate that an increase in glucose concentration at the macula densa blunts the TGF response and enhances NOgeneration via SGLT1. | Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia.
Zhang J, Wei J, Jiang S, Xu L, Wang L, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R., Free PMC Article | 12/21/2019 |
| In gastrointestinal - inflamed mice, over-stimulated incretin secretion and insulin release in response to glucose and sodium glucose cotransporter (Sglt1) was increased. | GI inflammation Increases Sodium-Glucose Cotransporter Sglt1.
Park J, Lee IS, Kim KH, Kim Y, An EJ, Jang HJ., Free PMC Article | 11/23/2019 |
| One day aftertraumatic brain injury, SGLT1 mRNA in the ipsilateral cortex was increased 160% in wild-type and 40% in RS1 knockout | RS1 (Rsc1A1) deficiency limits cerebral SGLT1 expression and delays brain damage after experimental traumatic brain injury.
Sebastiani A, Greve F, Gölz C, Förster CY, Koepsell H, Thal SC. | 10/5/2019 |
| Here we show that both human and murine endometrial epithelial cells express the high affinity Na(+)-coupled glucose carrier SGLT1. Ussing chamber experiments revealed electrogenic glucose transport across the endometrium in wild type (Slc5a1 (+/+)) but not in SGLT1 deficient (Slc5a1 (-/-)) mice. | Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.
Salker MS, Singh Y, Zeng N, Chen H, Zhang S, Umbach AT, Fakhri H, Kohlhofer U, Quintanilla-Martinez L, Durairaj RRP, Barros FSV, Vrljicak P, Ott S, Brucker SY, Wallwiener D, Vrhovac Madunić I, Breljak D, Sabolić I, Koepsell H, Brosens JJ, Lang F., Free PMC Article | 06/29/2019 |
| Loss or impairment of SGLT1 results in abnormal pancreatic islet (cyto)morphology and disturbed islet function regarding the insulin or glucagon release capacity from beta- or alpha-cells, respectively. | Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet.
Mühlemann M, Zdzieblo D, Friedrich A, Berger C, Otto C, Walles H, Koepsell H, Metzger M., Free PMC Article | 05/25/2019 |
| FGF-21 regulates glucose level in diabetes partially due to inhibiting glucose absorption in the SI via inactivating SGK-1 pathway. | Fibroblast growth factor 21 improves glucose homeostasis partially via down-regulation of Na(+)-d-glucose cotransporter SGLT1 in the small intestine.
Wang N, Li S, Guo XC, Li JY, Ren GP, Li DS. | 03/30/2019 |
| In conclusion, the activation of JNK and p38 after cerebral ischemia caused an increase in cerebral SGLT-1. The regulation of cerebral SGLT-1 expression via the MAPK pathway may be a novel therapeutic strategy for cerebral ischemia patients. | Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1.
Yamazaki Y, Arita K, Harada S, Tokuyama S. | 02/16/2019 |
| results suggest that rhythmic expression of Sglt1 is regulated at the mRNA transcriptional elongation level by enhancing the binding of the BRD4-P-TEFb complex to acetylated histones at the gene upon BMAL1-CLOCK binding to Sglt1 | Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb.
Yamauchi H, Honma K, Mochizuki K, Goda T. | 09/29/2018 |