Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling. | Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling. Xie S, Zou W, Liu S, Yang Q, Hu T, Zhu WP, Tang H, Wang C. | 04/15/2024 |
SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation. | SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation. Li Y, Wang T, Li X, Li W, Lei Y, Shang Q, Zheng Z, Fang J, Cao L, Yu D, Meng Z, Zhang S, Liu R, Liu C, Xu C, Ding Y, Chen Y, Candi E, Melino G, Wang Y, Shi Y, Shao C. | 04/11/2024 |
SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential. | SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential. Tamagawa S, Sakai D, Nojiri H, Nakamura Y, Warita T, Matsushita E, Schol J, Soma H, Ogasawara S, Munesada D, Koike M, Shimizu T, Sato M, Ishijima M, Watanabe M., Free PMC Article | 04/1/2024 |
Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation. | Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation. Díaz-Jara E, Pereyra K, Vicencio S, Olesen MA, Schwarz KG, Toledo C, Díaz HS, Quintanilla RA, Del Rio R., Free PMC Article | 02/2/2024 |
Overexpression of manganese superoxide dismutase mitigates ACL injury-induced muscle atrophy, weakness and oxidative damage. | Overexpression of manganese superoxide dismutase mitigates ACL injury-induced muscle atrophy, weakness and oxidative damage. Latham CM, Balawender PJ, Thomas NT, Keeble AR, Brightwell CR, Ismaeel A, Wen Y, Fry JL, Sullivan PG, Johnson DL, Noehren B, Owen AM, Fry CS., | 01/29/2024 |
CNS-oxygen toxicity and blood glucose levels in MnSOD enzyme knockdown mice. | CNS-oxygen toxicity and blood glucose levels in MnSOD enzyme knockdown mice. Rabinovitz R, Eynan M. | 09/7/2023 |
beta-secretase 1 overexpression by AAV-mediated gene delivery prevents retina degeneration in a mouse model of age-related macular degeneration. | β-secretase 1 overexpression by AAV-mediated gene delivery prevents retina degeneration in a mouse model of age-related macular degeneration. Qi X, Francelin C, Mitter S, Boye SL, Gu H, Quigley J, Grant MB, Boulton ME., | 07/23/2023 |
Protective effects of Cu/Zn-SOD and Mn-SOD on UVC radiation-induced damage in NIH/3T3 cells and murine skin. | Protective effects of Cu/Zn-SOD and Mn-SOD on UVC radiation-induced damage in NIH/3T3 cells and murine skin. Chen D, Ai X, Li Y, Li Y, Ao Y, Rong J, Li G. | 05/30/2023 |
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis. | Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis. Bhaskaran S, Kumar G, Thadathil N, Piekarz KM, Mohammed S, Lopez SD, Qaisar R, Walton D, Brown JL, Murphy A, Smith N, Saunders D, Beckstead MJ, Plafker S, Lewis TL Jr, Towner R, Deepa SS, Richardson A, Axtell RC, Van Remmen H., Free PMC Article | 01/21/2023 |
Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging. | Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging. Sonkar VK, Eustes AS, Ahmed A, Jensen M, Solanki MV, Swamy J, Kumar R, Fidler TP, Houtman JCD, Allen BG, Spitz DR, Abel ED, Dayal S., Free PMC Article | 12/31/2022 |
A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2. | A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2. Ning L, Rui X, Guorui L, Tinglv F, Donghang L, Chenzhen X, Xiaojing W, Qing G. | 12/10/2022 |
Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis. | Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis. Baier MP, Nagaraja RY, Yarbrough HP, Owen DB, Masingale AM, Ranjit R, Stiles MA, Murphy A, Agbaga MP, Ahmad M, Sherry DM, Kinter MT, Van Remmen H, Logan S., Free PMC Article | 08/13/2022 |
Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis. | Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis. Bao W, Xing H, Cao S, Long X, Liu H, Ma J, Guo F, Deng Z, Liu X., Free PMC Article | 08/13/2022 |
Heterozygous SOD2 deletion selectively impairs SERCA function in the soleus of female mice. | Heterozygous SOD2 deletion selectively impairs SERCA function in the soleus of female mice. Braun JL, Messner HN, Cleverdon REG, Baranowski RW, Hamstra SI, Geromella MS, Stuart JA, Fajardo VA., Free PMC Article | 05/28/2022 |
Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice. | Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice. Schoppa AM, Chen X, Ramge JM, Vikman A, Fischer V, Haffner-Luntzer M, Riegger J, Tuckermann J, Scharffetter-Kochanek K, Ignatius A., Free PMC Article | 05/21/2022 |
SOD2 in skeletal muscle: New insights from an inducible deletion model. | SOD2 in skeletal muscle: New insights from an inducible deletion model. Zhuang A, Yang C, Liu Y, Tan Y, Bond ST, Walker S, Sikora T, Laskowski A, Sharma A, de Haan JB, Meikle PJ, Shimizu T, Coughlan MT, Calkin AC, Drew BG., Free PMC Article | 12/18/2021 |
The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells. | The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells. Manes TL, Simenauer A, Geohring JL, Flemming J, Brehm M, Cota-Gomez A., Free PMC Article | 08/7/2021 |
SOD2 deficiency-induced oxidative stress attenuates steroidogenesis in mouse ovarian granulosa cells. | SOD2 deficiency-induced oxidative stress attenuates steroidogenesis in mouse ovarian granulosa cells. Zaidi SK, Shen WJ, Cortez Y, Bittner S, Bittner A, Arshad S, Huang TT, Kraemer FB, Azhar S., Free PMC Article | 07/31/2021 |
SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy. | SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy. Sharma S, Bhattarai S, Ara H, Sun G, St Clair DK, Bhuiyan MS, Kevil C, Watts MN, Dominic P, Shimizu T, McCarthy KJ, Sun H, Panchatcharam M, Miriyala S., Free PMC Article | 07/3/2021 |
Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway. | Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway. Song JQ, Jiang LY, Fu CP, Wu X, Liu ZL, Xie L, Wu XD, Hao SY, Li SQ., Free PMC Article | 06/5/2021 |
General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease. | General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease. Lv T, Lu Y, Liu Y, Feng H, Li C, Sheng W, Cui Z, Zhu S, Gu X, Yang Z, Wan Q., Free PMC Article | 05/22/2021 |
Sod2 and catalase improve pathological conditions of intervertebral disc degeneration by modifying human adipose-derived mesenchymal stem cells. | Sod2 and catalase improve pathological conditions of intervertebral disc degeneration by modifying human adipose-derived mesenchymal stem cells. Xiao L, Xu SJ, Liu C, Wang J, Hu B, Xu HG. | 03/6/2021 |
Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels. | Enhanced activity of superoxide dismutase is a common response to dietary and genetically induced increased cholesterol levels. Dominko K, Dikic D, Hecimovic S. | 01/23/2021 |
Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons. | Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons. Zhao Q, Lu D, Wang J, Liu B, Cheng H, Mattson MP, Cheng A., Free PMC Article | 09/5/2020 |
The knockdown of Zip8 impaired activity of the Mn-dependent SOD2. | Manganese influx and expression of ZIP8 is essential in primary myoblasts and contributes to activation of SOD2. Gordon SJV, Fenker DE, Vest KE, Padilla-Benavides T., Free PMC Article | 06/6/2020 |