| CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis. | CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.
Liu Q, Hu Y, Jie H, Lu W, Chen Y, Xing X, Tang B, Xu G, Sun J, Liang Y. | 04/5/2024 |
| Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity. | Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity.
Katsuda T, Sussman JH, Ito K, Katznelson A, Yuan S, Takenaka N, Li J, Merrell AJ, Cure H, Li Q, Rasool RU, Asangani IA, Zaret KS, Stanger BZ., Free PMC Article | 02/29/2024 |
| METTL3-mediated m[6]A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition. | METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.
Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY. | 02/1/2024 |
| SOX4 as a potential therapeutic target for pathological cardiac hypertrophy. | SOX4 as a potential therapeutic target for pathological cardiac hypertrophy.
Bin S, Xinyi F, Huan P, Xiaoqin Z, Jiming W, Yi H, Ziyue L, Xiaochun Z, Zhouqi L, Bangwei Z, Jing J, Shihui L, Jinlai G. | 10/11/2023 |
| SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. | SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis.
Cheng CK, Lin X, Pu Y, Tse JKY, Wang Y, Zhang CL, Cao X, Lau CW, Huang J, He L, Luo JY, Shih YT, Wan S, Ng CF, Wang L, Ma RCW, Chiu JJ, Chan TF, Yu Tian X, Huang Y., Free PMC Article | 02/11/2023 |
| SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARgamma complex. | SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex.
Shen H, He T, Wang S, Hou L, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H, Li B., Free PMC Article | 01/7/2023 |
| SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes. | SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes.
Jones K, Ramirez-Perez S, Niu S, Gangishetti U, Drissi H, Bhattaram P., Free PMC Article | 05/14/2022 |
| The transcription factor Sox4 is required for thymic tuft cell development. | The transcription factor Sox4 is required for thymic tuft cell development.
Mino N, Muro R, Ota A, Nitta S, Lefebvre V, Nitta T, Fujio K, Takayanagi H. | 03/26/2022 |
| Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation. | Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation.
Roukens MG, Frederiks CL, Seinstra D, Braccioli L, Khalil AA, Pals C, De Neck S, Bornes L, Beerling E, Mokry M, de Bruin A, Westendorp B, van Rheenen J, Coffer PJ., Free PMC Article | 01/1/2022 |
| HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways. | HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways.
Miyamoto R, Kanai A, Okuda H, Komata Y, Takahashi S, Matsui H, Inaba T, Yokoyama A., Free PMC Article | 11/13/2021 |
| Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice. | Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice.
Zhang L, Lv L, Zheng N, Li R, Yang R, Li T, Li Y, Liu Y, Luo H, Li X, Zhou Y, Shan H, Bai B, Liang H. | 09/11/2021 |
| SOX8 is an important mediator of Sertoli cell maturation. SOX8 regulates gene expression related to the extracellular matrix. SOX4 and SOX8 influence gene expression involved in cell-to-cell interactions. | Transcriptomic analysis of overexpressed SOX4 and SOX8 in TM4 Sertoli cells with emphasis on cell-to-cell interactions.
Roumaud P, Martin LJ. | 03/28/2020 |
| Data indicate that the reactivated embryonic gene program during wound repair and that SRY-box containing gene 11 protein (SOX11) and SRY-box containing gene 4 protein (SOX4) play a central role in this process. | SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair.
Miao Q, Hill MC, Chen F, Mo Q, Ku AT, Ramos C, Sock E, Lefebvre V, Nguyen H., Free PMC Article | 01/4/2020 |
| Upregulation of tenascin C mRNA was observed with overexpression of Sox4, suggesting a causal relationship between the two events in mammary gland Involution. | Transcription Factor Sox4 as a Potential Player in Mammary Gland Involution.
Shibayama H, Yamamoto T, Oshima K, Matsuda T, Nadano D. | 10/19/2019 |
| the High Mobility Group (HMG) transcription factor (TF) SOX4 controls the production of iNKT cells by inducing MicroRNA-181 (Mir181) to enhance TCR signaling and Ca(2+) fluxes in precursors. These results suggest the existence of tailored, permissive gene circuits in iNKT precursors for innate-like T cell development. | SOX4 controls invariant NKT cell differentiation by tuning TCR signaling.
Malhotra N, Qi Y, Spidale NA, Frascoli M, Miu B, Cho O, Sylvia K, Kang J., Free PMC Article | 09/7/2019 |
| SOX4 appears to be an important tumor oncogene in the regulation of osteosarcoma cell proliferation, apoptosis, and invasion | DownRegulated SOX4 Expression Suppresses Cell Proliferation, Migration, and Induces Apoptosis in Osteosarcoma In Vitro and In Vivo.
Chen D, Hu C, Wen G, Yang Q, Zhang C, Yang H. | 02/9/2019 |
| Sox4 expression levels are markedly upregulated in livers of obese rodents and humans. Adenovirus-medicated overexpression of Sox4 in the livers of lean mice promotes liver steatosis, whereas liver-specific knockdown of Sox4 ameliorates triglyceride accumulation and improves insulin resistance in obese mice. | SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c.
Jiao Y, Zhao J, Zhang Z, Li M, Yu X, Yang Y, Liu J, Liao S, Li D, Wang Y, Zhang D, Chen Y, Shi G, Liu B, Lu Y, Li X. | 12/29/2018 |
| Sox4 promoted tuft and enteroendocrine cell lineage allocation independently of Atoh1. These results challenge the longstanding model in which Atoh1 is the sole regulator of secretory differentiation in the intestine and are relevant for understanding epithelial responses to parasitic infection. | Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates.
Gracz AD, Samsa LA, Fordham MJ, Trotier DC, Zwarycz B, Lo YH, Bao K, Starmer J, Raab JR, Shroyer NF, Reinhardt RL, Magness ST., Free PMC Article | 12/22/2018 |
| SOX4 (and, to a lesser extent, SOX11 and -12) repressed transcription of the sex-determining gene Sox9 via an upstream testis-specific enhancer core (TESCO) element in fetal gonads. | SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.
Zhao L, Arsenault M, Ng ET, Longmuss E, Chau TC, Hartwig S, Koopman P. | 06/10/2017 |
| These data suggest that increased SOX4 expression inhibits insulin secretion and increased diabetes risk by the upregulation of STXBP6 and an increase in kiss-and-run exocytosis at the expense of full fusion. | Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion.
Collins SC, Do HW, Hastoy B, Hugill A, Adam J, Chibalina MV, Galvanovskis J, Godazgar M, Lee S, Goldsworthy M, Salehi A, Tarasov AI, Rosengren AH, Cox R, Rorsman P., Free PMC Article | 06/10/2017 |
| Taken together, our findings indicate that miR-363-3p is involved in CRC metastasis and functions as a tumor suppressor via negatively regulating Sox4. Therefore, the up-regulation of miR-363-3p in human CRC may have therapeutic benefits. | MiR-363-3p inhibits the epithelial-to-mesenchymal transition and suppresses metastasis in colorectal cancer by targeting Sox4.
Hu F, Min J, Cao X, Liu L, Ge Z, Hu J, Li X. | 05/13/2017 |
| Sox4 sense and natural antisense transcripts formed dsRNA aggregates in the cytoplasm of brain cells. Over expression of Sox4 NATs in NIH/3T3 cells generally did not alter the level of Sox4 mRNA expression or protein translation. Upregulation of a Sox4 NAT known as Sox4ot1 led to the production of a novel small RNA, Sox4_sir3. | Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain.
Ling KH, Brautigan PJ, Moore S, Fraser R, Cheah PS, Raison JM, Babic M, Lee YK, Daish T, Mattiske DM, Mann JR, Adelson DL, Thomas PQ, Hahn CN, Scott HS. | 11/5/2016 |
| SOXC proteins act cell- and non-cell-autonomously in perichondrocytes and chondrocytes to establish noncanonical WNT signaling crosstalk essential for growth plate induction and control | SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.
Kato K, Bhattaram P, Penzo-Méndez A, Gadi A, Lefebvre V., Free PMC Article | 06/28/2016 |
| The microRNA-212/micro-132 cluster regulates B cell development by targeting Sox4. | The microRNA-212/132 cluster regulates B cell development by targeting Sox4.
Mehta A, Mann M, Zhao JL, Marinov GK, Majumdar D, Garcia-Flores Y, Du X, Erikci E, Chowdhury K, Baltimore D., Free PMC Article | 04/30/2016 |
| The expression of putative SOX4 target genes during myoblast differentiation is specifically regulated by the molecular switching of the co-activator KAT5 and the co-repressor HDAC1 on SOX4 transcriptional activation. | KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation.
Jang SM, Kim JW, Kim CH, An JH, Johnson A, Song PI, Rhee S, Choi KH., Free PMC Article | 04/16/2016 |