| A comparative analysis between WT and Spam1/Hyal5 dKO epididymal sperm revealed that the absence of these 2 sperm Hyals resulted in a marked accumulation of sperm on the outside of the cumulus-oocyte complex. | SPAM1/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus-oocyte complex penetration defect.
Park S, Kim YH, Jeong PS, Park C, Lee JW, Kim JS, Wee G, Song BS, Park BJ, Kim SH, Sim BW, Kim SU, Triggs-Raine B, Baba T, Lee SR, Kim E. | 06/13/2020 |
| PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination. | Digestion products of the PH20 hyaluronidase inhibit remyelination.
Preston M, Gong X, Su W, Matsumoto SG, Banine F, Winkler C, Foster S, Xing R, Struve J, Dean J, Baggenstoss B, Weigel PH, Montine TJ, Back SA, Sherman LS., Free PMC Article | 05/25/2013 |
| ACR or PRSS21 or both may function cooperatively with SPAM1 in sperm/cumulus penetration | Functional characterization of double-knockout mouse sperm lacking SPAM1 and ACR or SPAM1 and PRSS21 in fertilization.
Zhou C, Kang W, Baba T. | 12/22/2012 |
| The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase SPAM1 may not be required for fertilization, at least in the mouse. | Hyaluronan-degrading activity of mouse sperm hyaluronidase is not required for fertilization?
Kang W, Zhou C, Koga Y, Baba T. | 04/19/2010 |
| SPAM1 may function in sperm entry into the cumulus and sperm penetration through the cumulus matrix. | Functional roles of mouse sperm hyaluronidases, HYAL5 and SPAM1, in fertilization.
Kimura M, Kim E, Kang W, Yamashita M, Saigo M, Yamazaki T, Nakanishi T, Kashiwabara S, Baba T. | 01/21/2010 |
| First documentation of vesicular interaction with the sperm plasma membrane provides a model for the possible transfer mechanism of SPAM1 and other glycosyl phosphatidylinositol (GPI)-linked proteins to the sperm surface in reproductive fluids. | Investigating the role of murine epididymosomes and uterosomes in GPI-linked protein transfer to sperm using SPAM1 as a model.
Griffiths GS, Galileo DS, Reese K, Martin-Deleon PA. | 01/21/2010 |
| sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg | Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg.
Baba D, Kashiwabara S, Honda A, Yamagata K, Wu Q, Ikawa M, Okabe M, Baba T. | 01/21/2010 |
| Sperm adhesion molecule 1 (SPAM1) is distributed in the nonciliated epithelial cells. Efferent ducts have the most intense staining. Spam1 was also present in the accessory organs, the prostate, and seminal vesicles and its fluid. | Spam1 (PH-20) expression in the extratesticular duct and accessory organs of the mouse: a possible role in sperm fluid reabsorption.
Zhang H, Morales CR, Badran H, El-Alfy M, Martin-DeLeon PA. | 01/21/2010 |
| Spam1 is a multifunctional protein and that it is less restricted in its expression than previously reported | Mouse Spam1 (PH-20) is a multifunctional protein: evidence for its expression in the female reproductive tract.
Zhang H, Martin-DeLeon PA. | 01/21/2010 |
| SPAM1 is implicated in fluid reabsorption and urine concentration | Expression of SPAM1 (PH-20) in the murine kidney is not accompanied by hyaluronidase activity: evidence for potential roles in fluid and water reabsorption.
Grigorieva A, Griffiths GS, Zhang H, Laverty G, Shao M, Taylor L, Martin-DeLeon PA. | 01/21/2010 |
| Mouse SPAM1 and HYAL5 but not HYALP1 proteins exhibit hyaluronidase activity at neutral pH. | Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan.
Reitinger S, Laschober GT, Fehrer C, Greiderer B, Lepperdinger G., Free PMC Article | 01/21/2010 |
| Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction. | Spam1 (PH-20) mutations and sperm dysfunction in mice with the Rb(6.16) or Rb(6.15) translocation.
Zheng Y, Deng X, Zhao Y, Zhang H, Martin-DeLeon PA. | 01/21/2010 |
| Epididymal Spam1 is secreted predominantly as insoluble particles. Majority of epididymal Spam1 is released with its lipid anchor, a form in which it can bind to sperm. | Mouse epididymal Spam1 (pH-20) is released in the luminal fluid with its lipid anchor.
Zhang H, Martin-Deleon PA. | 01/21/2010 |
| Testicular compartmentalization of Spam1 RNA provides strong support for the lack of sharing hypothesis, and represents a possible mechanism of Spam1-associated transmission ratio distortion . | Spam1-associated transmission ratio distortion in mice: elucidating the mechanism.
Martin-DeLeon PA, Zhang H, Morales CR, Zhao Y, Rulon M, Barnoski BL, Chen H, Galileo DS., Free PMC Article | 01/21/2010 |