IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression. | IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell leukemia results in altered DNA binding and altered STAT5-dependent gene expression. Rodrigues de Oliveira B, Iansavitchous J, Rysan H, Wang WC, Sams MP, Knight D, Xu LS, Jeong J, Qu TP, Zorzi AP, DeKoter RP. | 02/4/2024 |
Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes. | Abnormal M1 polarization of placental macrophage induced by IL-15/STAT5 activation in VVC may lead to adverse pregnancy outcomes. Zhang Y, Zhao L, Wu A, Lin P, Fan J, Chen J, Wang X, Zeng X. | 02/1/2024 |
ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2alpha/CHOP signaling pathway in an m[6]A-YTHDF1-dependent manner. | ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an m(6)A-YTHDF1-dependent manner. Liu C, Chen H, Tao X, Li C, Li A, Wu W. | 01/4/2024 |
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction. | Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction. Harvey I, Richard AJ, Mendoza TM, Stephens JM., | 11/7/2023 |
Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Niche Factors. | Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Niche Factors. Wang Z, Emmel G, Lim HS, Zhu W, Kosters A, Ghosn EEB, Qiu P, Bunting KD., Free PMC Article | 10/10/2023 |
The Kruppel-like factor 4-signal transducer and activator of transcription 5A axis promotes pancreatic fibrosis in mice with caerulein-induced chronic pancreatitis. | The Kruppel-like factor 4-signal transducer and activator of transcription 5A axis promotes pancreatic fibrosis in mice with caerulein-induced chronic pancreatitis. Wang X, Yu L, Chen Y, Xiong X, Ran H., Free PMC Article | 08/9/2023 |
STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia. | STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia. Tremblay CS, Saw J, Boyle JA, Haigh K, Litalien V, McCalmont H, Evans K, Lock RB, Jane SM, Haigh JJ, Curtis DJ. | 07/21/2023 |
Tetramerization of STAT5 regulates monocyte differentiation and the dextran sulfate sodium-induced colitis in mice. | Tetramerization of STAT5 regulates monocyte differentiation and the dextran sulfate sodium-induced colitis in mice. Monaghan KL, Zheng W, Akhter H, Wang L, Ammer AG, Li P, Lin JX, Hu G, Leonard WJ, Wan ECK., Free PMC Article | 05/18/2023 |
An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism. | An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism. Zhang Z, Salgado OC, Liu B, Moazzami Z, Hogquist KA, Farrar MA, Ruan HB., Free PMC Article | 08/6/2022 |
PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. | PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. Grinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ., Free PMC Article | 05/14/2022 |
Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis. | Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis. Richard AJ, Hang H, Allerton TD, Zhao P, Mendoza T, Ghosh S, Elks CM, Stephens JM., Free PMC Article | 04/30/2022 |
The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation. | The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation. Jurado S, Fedl AS, Jaritz M, Kostanova-Poliakova D, Malin SG, Mullighan CG, Strehl S, Fischer M, Busslinger M., Free PMC Article | 04/9/2022 |
Growth hormone receptor contributes to the activation of STAT5 in the hypothalamus of pregnant mice. | Growth hormone receptor contributes to the activation of STAT5 in the hypothalamus of pregnant mice. Wasinski F, Teixeira PDS, List EO, Kopchick JJ, Donato J Jr., Free PMC Article | 03/19/2022 |
Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. | Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. Kahan SM, Bakshi RK, Ingram JT, Hendrickson RC, Lefkowitz EJ, Crossman DK, Harrington LE, Weaver CT, Zajac AJ., Free PMC Article | 03/12/2022 |
STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment. | STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment. Jesser EA, Brady NJ, Huggins DN, Witschen PM, O'Connor CH, Schwertfeger KL., Free PMC Article | 03/5/2022 |
STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T-cell sensitivity to PD-1-dependent immunoregulation. | STAT5 interferes with PD-1 transcriptional activation and affects CD8+ T-cell sensitivity to PD-1-dependent immunoregulation. Wang G, Tajima M, Honjo T, Ohta A. | 02/19/2022 |
Dnmt3a is downregulated by Stat5a and mediates G0/G1 arrest by suppressing the miR-17-5p/Cdkn1a axis in Jak2(V617F) cells. | Dnmt3a is downregulated by Stat5a and mediates G0/G1 arrest by suppressing the miR-17-5p/Cdkn1a axis in Jak2(V617F) cells. Zhou J, Guo C, Wu H, Li B, Zhou LL, Liang AB, Fu JF., Free PMC Article | 02/19/2022 |
Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation. | Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation. Monaghan KL, Aesoph D, Ammer AG, Zheng W, Rahimpour S, Farris BY, Spinner CA, Li P, Lin JX, Yu ZX, Lazarevic V, Hu G, Leonard WJ, Wan ECK., Free PMC Article | 02/12/2022 |
Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. | Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice. Beghini M, Wagner T, Luca AC, Metz M, Kaltenecker D, Spirk K, Hackl MT, Haybaeck J, Moriggl R, Kautzky-Willer A, Scherer T, Fürnsinn C., Free PMC Article | 01/8/2022 |
Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells. | Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells. Hsiung S, Moro A, Ban Y, Chen X, Savio AS, Hernandez R, Malek TR. | 11/13/2021 |
Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. | Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. Gustafson P, Ladyman SR, McFadden S, Larsen C, Khant Aung Z, Brown RSE, Bunn SJ, Grattan DR. | 10/30/2021 |
H2AX Promoter Demethylation at Specific Sites Plays a Role in STAT5-Induced Tumorigenesis. | H2AX Promoter Demethylation at Specific Sites Plays a Role in STAT5-Induced Tumorigenesis. Havusha-Laufer S, Kosenko A, Kisliouk T, Barash I. | 10/2/2021 |
Stat5a promotes brown adipocyte differentiation and thermogenic program through binding and transactivating the Kdm6a promoter. | Stat5a promotes brown adipocyte differentiation and thermogenic program through binding and transactivating the Kdm6a promoter. Liu W, Ji Y, Zhang B, Chu H, Yin C, Xiao Y., Free PMC Article | 07/24/2021 |
STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue. | STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue. Kaltenecker D, Spirk K, Ruge F, Grebien F, Herling M, Rupprecht A, Kenner L, Pohl EE, Mueller KM, Moriggl R., Free PMC Article | 07/10/2021 |
STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes. | STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes. Hao P, Waxman DJ., Free PMC Article | 02/6/2021 |