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    Strap serine/threonine kinase receptor associated protein [ Mus musculus (house mouse) ]

    Gene ID: 20901, updated on 23-Jun-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.

    STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.
    Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK, Scarduzio M, Wang H, Chang C, Datta PK., Free PMC Article

    12/19/2020
    Loss of Strap selectively induced Cyp26A1 expression in mouse EBs, suggesting a potential role of STRAP in RA signaling.

    Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis.
    Jin L, Chang C, Pawlik KM, Datta A, Johnson LM, Vu T, Napoli JL, Datta PK.

    12/7/2019
    LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.

    LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.
    Hu X, Mullins RD., Free PMC Article

    10/26/2019
    Strap associates with Csde1 and affects expression of select Csde1-bound transcripts

    Strap associates with Csde1 and affects expression of select Csde1-bound transcripts.
    Moore KS, Yagci N, van Alphen F, Meijer AB, 't Hoen PAC, von Lindern M., Free PMC Article

    02/9/2019
    STRAP is a new scaffold protein that functions in Toll-like receptor-mediated immune responses. STRAP specifically binds TGF beta-activated kinase 1 and IKKalpha along with NF-kappaB subunit p65, leading to enhanced association between TAK1, IKKalpha, and p65, and subsequent facilitation of p65 phosphorylation and nuclear translocation. The C-terminal region of STRAP is essential for its functional activity in upregula...

    STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway.
    Huh HD, Ra EA, Lee TA, Kang S, Park A, Lee E, Choi JL, Jang E, Lee JE, Lee S, Park B., Free PMC Article

    07/7/2018
    these results suggest that STRAP increases invasion and metastasis of colorectal cancer partly through inhibiting ubiquitin-dependent degradation of beta-catenin and promoting Wnt/beta-catenin signaling

    Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling.
    Yuan G, Zhang B, Yang S, Jin L, Datta A, Bae S, Chen X, Datta PK., Free PMC Article

    12/9/2017
    findings indicate serine/threonine kinase receptor associated protein (STRAP) is expressed in the mouse ovary and is capable of regulating development of small follicles in a stage-dependent manner

    Serine threonine kinase receptor associated protein regulates early follicle development in the mouse ovary.
    Sharum IB, Granados-Aparici S, Warrander FC, Tournant FP, Fenwick MA.

    10/21/2017
    this study shows that STRAP is a positive regulator of the TLR3-meditated NF-kappaB and IRF signaling pathway

    STRAP positively regulates TLR3-triggered signaling pathway.
    Huh HD, Lee E, Shin J, Park B, Lee S.

    09/16/2017
    STRAP Ser(188) phosphorylation in the liver is tightly associated with cell death and proliferation through ASK1, TGF-beta, p53, and PI3K/PDK1 pathways, resulting in apoptotic cell death.

    A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways.
    Seong HA, Manoharan R, Ha H., Free PMC Article

    07/25/2015
    Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I) mRNAs.

    Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs.
    Vukmirovic M, Manojlovic Z, Stefanovic B., Free PMC Article

    11/30/2013
    both of the TPR and OB-fold domains localize to the chromatin of p53 target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 response

    The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
    Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN., Free PMC Article

    05/5/2012
    STRAP regulates c-Jun stability by decreasing the ubiquitylation and proteosomal degradation of c-Jun.

    STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation.
    Reiner J, Ye F, Kashikar ND, Datta PK., Free PMC Article

    06/4/2011
    report that deletion of STRAP from Mouse Embryonic Fibroblasts (MEFs) results in a loss of mesenchymal morphology.

    Serine threonine receptor-associated protein (STRAP) plays a role in the maintenance of mesenchymal morphology.
    Kashikar ND, Reiner J, Datta A, Datta PK., Free PMC Article

    01/21/2010
    NM23-H1 and its interacting partner STRAP physically interact with p53 and positively regulate its functions, including p53-induced apoptosis and cell cycle arrest

    NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function.
    Jung H, Seong HA, Ha H.

    01/21/2010
    Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway

    Gemin8 is required for the architecture and function of the survival motor neuron complex.
    Carissimi C, Saieva L, Gabanella F, Pellizzoni L.

    01/21/2010
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