| TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. | TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming.
Barbet G, Nair-Gupta P, Schotsaert M, Yeung ST, Moretti J, Seyffer F, Metreveli G, Gardner T, Choi A, Tortorella D, Tampé R, Khanna KM, García-Sastre A, Blander JM., Free PMC Article | 07/3/2021 |
| TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors. | TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
Doorduijn EM, Sluijter M, Querido BJ, Oliveira CC, Achour A, Ossendorp F, van der Burg SH, van Hall T., Free PMC Article | 07/16/2016 |
| It transport class I antigens to cell surface of CD8 positive lymphocytes which have a vital role in liver inflammation like fructose-induced steatosis. | Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice.
Arindkar S, Bhattacharjee J, Kumar JM, Das B, Upadhyay P, Asif S, Juyal RC, Majumdar SS, Perumal N. | 03/29/2014 |
| Knocking out Tap1 abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits. | MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression.
Nelson PA, Sage JR, Wood SC, Davenport CM, Anagnostaras SG, Boulanger LM., Free PMC Article | 02/22/2014 |
| Apoe(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe(-/-) mice, indicating a minor role for CD8(+) T cells and TAP1-dependent antigen presentation in the disease process. | TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice.
Kolbus D, Ljungcrantz I, Söderberg I, Alm R, Björkbacka H, Nilsson J, Fredrikson GN., Free PMC Article | 11/24/2012 |
| Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation. | Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation.
Lorente E, García R, Mir C, Barriga A, Lemonnier FA, Ramos M, López D., Free PMC Article | 05/19/2012 |
| Our data suggest that the normal influx of TAP-transported peptides in the ER during routine processing creates an efficient barrier for peptides from alternative processing routes. | Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires.
Oliveira CC, Querido B, Sluijter M, Derbinski J, van der Burg SH, van Hall T. | 12/3/2011 |
| A complete overview is presented of the applicability of herpesvirus-encoded TAP and tapasin inhibitors in mouse cells of different genetic background. | Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses.
Verweij MC, Ressing ME, Knetsch W, Quinten E, Halenius A, van Bel N, Hengel H, Drijfhout JW, van Hall T, Wiertz EJ. | 04/9/2011 |
| downregulation of expression in PBMC of chronic hepatitis B patients | Impaired antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis B virus infection.
Sukriti S, Pati NT, Bose S, Hissar SS, Sarin SK. | 09/27/2010 |
| Our results do not support a role for MHC class I (TAP1) in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons. | Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice.
Laguna Goya R, Tyers P, Barker RA. | 06/14/2010 |
| a new role for mouse TAP2 in stabilizing TAP1 protein expression is shown using the Jasmine strain; Jasmine has an A to C transversion in exon 5 of TAP2, resulting in a threonine to proline substitution at position 293 of the protein. | Mouse strains with point mutations in TAP1 and TAP2.
Theodoratos A, Whittle B, Enders A, Tscharke DC, Roots CM, Goodnow CC, Fahrer AM. | 01/25/2010 |
| Allergen-specific CD8+ T cells were recruited to and specifically activated in the lungs of sensitized animals after allergen-aerosol challenge, a process that was dependent on a functional TAP complex | Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype.
Aguilar-Pimentel JA, Alessandrini F, Huster KM, Jakob T, Schulz H, Behrendt H, Ring J, de Angelis MH, Busch DH, Mempel M, Ollert M. | 01/21/2010 |
| The furin-mediated secretory pathway provides approximately one-third of all surface peptide/histocompatibility class I complexes in wild-type TAP-competent cells. | Furin-processed antigens targeted to the secretory route elicit functional TAP1-/-CD8+ T lymphocytes in vivo.
Medina F, Ramos M, Iborra S, de León P, Rodríguez-Castro M, Del Val M. | 01/21/2010 |
| These data suggest that PSF1 is tightly regulated at the transcriptional level in stem cells. | Identification and characterization of stem cell-specific transcription of PSF1 in spermatogenesis.
Han Y, Ueno M, Nagahama Y, Takakura N. | 01/21/2010 |
| PSF1 is required for acute proliferation of hematopoietic stem cells in the bone marrow of mice. | Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration.
Ueno M, Itoh M, Sugihara K, Asano M, Takakura N. | 01/21/2010 |
| regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport by ERK map kinases requires TAP-NxT1 binding and the AU-rich element | Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element.
Skinner SJ, Deleault KM, Fecteau R, Brooks SA. | 01/21/2010 |
| role for TAP-1 in the induction of IFN-gamma-producing NK (naatural killer) cells and demonstration that NK cell licensing can influence host resistance to infection. | TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production.
Goldszmid RS, Bafica A, Jankovic D, Feng CG, Caspar P, Winkler-Pickett R, Trinchieri G, Sher A., Free PMC Article | 01/21/2010 |
| Presensitization of TAP1-/- mice with H-2K(b) peptides accelerated the rejection of C57BL/6 (H-2(b)) skin grafts. | Rejection of grafts without histocompatibility antigen disparity by TAP1-/- mice: a role for CD4+ T cells.
Marrero I, Benvenutti LA, Noronha I, Kalil J, Coelho V. | 01/21/2010 |
| These data suggest that PSF1 and SLD5 may cooperate in the proliferation of immature cell populations. | Identification and characterization of mouse PSF1-binding protein, SLD5.
Kong L, Ueno M, Itoh M, Yoshioka K, Takakura N. | 01/21/2010 |
| MHC conformational changes, revealed at molecular level, may influence the immunogenicity | Evidences of conformational changes in class II Major Histocompatibility Complex molecules that affect the immunogenicity.
Neveu R, Auriault C, Angyalosi G, Georges B. | 01/21/2010 |
| PSF1 is required for early embryogenesis | PSF1 is essential for early embryogenesis in mice.
Ueno M, Itoh M, Kong L, Sugihara K, Asano M, Takakura N., Free PMC Article | 01/21/2010 |
| A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression | A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.
Garbi N, Tiwari N, Momburg F, Hämmerling GJ. | 01/21/2010 |
| Macrophages cross-presented p33-VLP normally in the absence of TAP. The TAP-dependent pathway of cross-presentation is therefore confined to DC while both macrophages and DC harbor the TAP-independent pathway. | Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP.
Ruedl C, Storni T, Lechner F, Bächi T, Bachmann MF. | 01/21/2010 |
| Tap1 is required for class I major histocompatibility complex (MHC-I) to bind endoplasmic reticulum-derived stabilizing peptides to achieve stability needed for alternate MHC-I processing via peptide exchange in acidic vacuolar processing compartments. | Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH.
Chefalo PJ, Grandea AG 3rd, Van Kaer L, Harding CV. | 01/21/2010 |