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    Tbx5 T-box 5 [ Mus musculus (house mouse) ]

    Gene ID: 21388, updated on 7-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Tbx5 inhibits hedgehog signaling in determination of digit identity.

    Tbx5 inhibits hedgehog signaling in determination of digit identity.
    Xu H, Xiang M, Qin Y, Cheng H, Chen D, Fu Q, Zhang KK, Xie L., Free PMC Article

    08/14/2021
    Direct Cardiac Reprogramming for Cardiovascular Regeneration and Differentiation.

    Direct Cardiac Reprogramming for Cardiovascular Regeneration and Differentiation.
    Sadahiro T, Ieda M.

    07/17/2021
    Transcriptional Patterning of the Ventricular Cardiac Conduction System.

    Transcriptional Patterning of the Ventricular Cardiac Conduction System.
    Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Petrenko NB, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IP., Free PMC Article

    05/29/2021
    Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming.

    Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming.
    Zhang Z, Zhang W, Nam YJ., Free PMC Article

    11/21/2020
    Mice homozygous for Tbx5 R264K showed compensated dilated cardiomyopathy. Thus, TBX5 R264K may have a significant pathogenic role in some cardiomyopathy patients independently of T-box domain pathway.

    TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway.
    Miyao N, Hata Y, Izumi H, Nagaoka R, Oku Y, Takasaki I, Ishikawa T, Takarada S, Okabe M, Nakaoka H, Ibuki K, Ozawa S, Yoshida T, Hasegawa H, Makita N, Nishida N, Mori H, Ichida F, Hirono K., Free PMC Article

    07/11/2020
    These results directly link transcriptional control of SERCA2 activity, depressed sarcoplasmic reticulum Ca(2+) sequestration, enhanced trans-sarcolemmal calcium fluxes, and atrial fibrillation, establishing a mechanism underlying the genetic basis for a Ca(2+)-dependent pathway for atrial fibrillation risk in Tbx5-deficient mice.

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
    Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR., Free PMC Article

    04/4/2020
    Normal downregulation of the definitive arterial pole progenitor cell program in the posterior of the Second Heart Field (SHF) is dependent on both Tbx1 and Tbx5. Furthermore, retinoic acid (RA) signaling is required for Tbx5 activation in Tbx1-positive cells and blocking RA signaling at the time of Tbx5 activation results in atrioventricular septal defects at fetal stages.

    T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart field.
    De Bono C, Thellier C, Bertrand N, Sturny R, Jullian E, Cortes C, Stefanovic S, Zaffran S, Théveniau-Ruissy M, Kelly RG.

    04/27/2019
    Enrichment of induced cardiomyocytes derived from mouse fibroblasts can be achieved by reprogramming with cardiac transcription factors, Gata4, MEF2c, Tbx5, and Hand2.

    Optimization and enrichment of induced cardiomyocytes derived from mouse fibroblasts by reprogramming with cardiac transcription factors.
    Tian J, Wang R, Hou Q, Li M, Chen L, Deng X, Zhu Z, Zhao Y, He W, Fu X.

    08/18/2018
    Defined a transcriptional architecture for atrial rhythm control organized as an incoherent feed-forward loop, driven by TBX5 and modulated by PITX2. TBX5/PITX2 interplay provides tight control of atrial rhythm effector gene expression, and perturbation of the co-regulated network caused atrial fibrillation susceptibility.

    Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
    Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP., Free PMC Article

    12/23/2017
    The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.

    KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.
    Darwich R, Li W, Yamak A, Komati H, Andelfinger G, Sun K, Nemer M.

    05/20/2017
    Our data demonstrate an early, inherent asymmetry in the left and right limb-forming regions and that threshold levels of Tbx5 are required to overcome this asymmetry to ensure symmetric forelimb formation.

    Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation.
    Sulaiman FA, Nishimoto S, Murphy GR, Kucharska A, Butterfield NC, Newbury-Ecob R, Logan MP., Free PMC Article

    05/13/2017
    Data show that three transcriptional factors Gata4, Mef2c, and Tbx5 (abbreviated as GMT) significantly improved murine embryonic stem cells (ESCs) differentiated into cardiomyocytes.

    Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors.
    Bai F, Ho Lim C, Jia J, Santostefano K, Simmons C, Kasahara H, Wu W, Terada N, Jin S., Free PMC Article

    08/20/2016
    defines a TBX5-nucleosome remodeling and deacetylase interaction essential to cardiac development and the evolution of the mammalian heart

    The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
    Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, Temple B, Yang XH, Wilczewski CM, Davis IJ, Cristea IM, Moskowitz IP, Conlon FL., Free PMC Article

    08/13/2016
    Study reports extensive and complex interdependent genomic occupancy of TBX5, NKX2-5, and the zinc finger TF GATA4 coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

    Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
    Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG.,

    07/30/2016
    Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.

    Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.
    Zhou L, Liu J, Olson P, Zhang K, Wynne J, Xie L., Free PMC Article

    05/21/2016
    Haploinsufficiency of Tbx5 and trisomy affects alignment of the aorta and this effect may stem from deviations from normal left-right patterning in the heart; study unveiled a previously unknown interaction between the Tbx5 gene and trisomy, suggesting a connection between Tbx5 and trisomic genes important during heart development.

    The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.
    Polk RC, Gergics P, Steimle JD, Li H, Moskowitz IP, Camper SA, Reeves RH., Free PMC Article

    01/16/2016
    These findings elucidate mechanisms regulating the commitment of mesodermal cells in the early embryo and identify the Tbx5 cardiac transcriptome.

    Pax3 and Tbx5 specify whether PDGFRα+ cells assume skeletal or cardiac muscle fate in differentiating embryonic stem cells.
    Magli A, Schnettler E, Swanson SA, Borges L, Hoffman K, Stewart R, Thomson JA, Keirstead SA, Perlingeiro RC., Free PMC Article

    10/10/2015
    these data suggest that the molecular pathogenesis of ventricular septal defectss in Moz germline mutant mice is due to loss of MOZ-dependant activation of mesodermal Tbx1 and Tbx5 expression.

    Mesodermal expression of Moz is necessary for cardiac septum development.
    Vanyai HK, Thomas T, Voss AK.

    09/12/2015
    our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 transcriptional activity.

    Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development.
    Jeong HS, Jung ES, Sim YJ, Kim SJ, Jang JW, Hong KS, Lee WY, Chung HM, Park KT, Jung YS, Kim CH, Kim KS.

    08/29/2015
    Our findings implicate Foxf genes in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog signaling and Tbx5, and establish a molecular model for the selection of the SHF gene regulatory network

    Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
    Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP., Free PMC Article

    07/4/2015
    Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.

    Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.
    Misra C, Chang SW, Basu M, Huang N, Garg V., Free PMC Article

    05/30/2015
    TBX5 isoforms derived from novel exons have distinct expression domains and function. Alternative splicing regulates TBX5 function in heart and limb.

    Novel exons in the tbx5 gene locus generate protein isoforms with distinct expression domains and function.
    Yamak A, Georges RO, Sheikh-Hassani M, Morin M, Komati H, Nemer M., Free PMC Article

    05/30/2015
    Tbx5 is a common node in the genetic pathways regulating forelimb and sternum development, enabling specific adaptations of thesefeatures without affecting other skeletal elements.

    Regulatory modulation of the T-box gene Tbx5 links development, evolution, and adaptation of the sternum.
    Bickley SR, Logan MP., Free PMC Article

    05/2/2015
    Data show that Hdac3 physically interacts with Tbx5 and modulates its acetylation to repress Tbx5-dependent activation of cardiomyocyte lineage-specific genes.

    Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis.
    Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM., Free PMC Article

    02/14/2015
    SRC-2 is critical to transcriptional control modulated by MEF2, GATA-4, and Tbx5, thereby enhancing gene expression associated with cardiac growth.

    Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function.
    Reineke EL, Benham A, Soibam B, Stashi E, Taegtmeyer H, Entman ML, Schwartz RJ, O'Malley BW., Free PMC Article

    10/11/2014
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